Seasonal Occurrence of Human Metapneumovirus Infections in Croatia

Ljubin‐Sternak, Sunčanica; Mlinarić‐Galinović, Gordana; Buntić, A; Tabain, Irena; Vilibić-Čavlek, Tatjana; Čepin-Bogović, Jasna; Tešović, Goran

doi:10.1097/inf.0000000000000026

Cited by 11 publications

(10 citation statements)

References 25 publications

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“…The present study provides insights into the molecular epidemiology and genetic variability of HMPV circulating in Croatia between April 2011 and March 2014. Our data is consistent with previous observations showing trend of high and low incidence of HMPV in alternating years (biennial pattern: larger winter and smaller spring outbreaks) in hospitalized patients . The majority of HMPV infections were detected in the cold period of the year which is similar to previous reports for temperate climate countries .…”

Section: Discussionsupporting

confidence: 93%

“…Our data is consistent with previous observations showing trend of high and low incidence of HMPV in alternating years (biennial pattern: larger winter and smaller spring outbreaks) in hospitalized patients. 12,[26][27][28][29] The majority of HMPV infections were detected in the cold period of the year which is similar to previous reports for temperate climate countries. [30][31][32] The winterspring HMPV occurrence is traditionally regarded as the typical pattern of HMPV infections in the temperate regions, however, seasonal peaks observed from May to July of 2011 and April to July in 2013 are unusual, and such pattern is typically seen in tropical countries.…”

Section: Discussionsupporting

confidence: 89%

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Genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Croatia

et al. 2017

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Human metapneumovirus (HMPV) is recognized as a global and frequent cause of acute respiratory tract infections among people of all ages. The objectives of this study were molecular epidemiology and evolutionary analysis of HMPV strains which produced moderate and severe acute respiratory tract infections in children in Croatia during four consecutive seasons (2011-2014). A total of 117 HMPV-positive samples collected from hospitalized pediatric patients presenting with acute respiratory tract infections and tested by direct immunofluorescence assay were first analyzed by amplifying a part of the F gene. Sixteen samples were further analyzed based on complete F, G, and SH gene sequences. HMPV genome was identified in 92 of 117 samples (78%) and the circulation of multiple lineages of HMPV was confirmed. In 2011, 2012, and 2014, subgroups A2 and B2 co-circulated, while B1 gained prevalence in 2013 and 2014. The study established the presence of a novel subcluster A2c in Croatia. This subcluster has only recently been detected in East and Southeast Asia. This study provides new insights into epidemiology and genetic diversity of HMPV in this part of Europe.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Croatia

et al. 2017

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“…A previous study conducted in Bangladesh reported a similar prevalence (4%) of hMPV infection . This finding also aligns with the proportion of hMPV‐positive cases reported in the studies conducted in Hong Kong (5.5%), USA (6.2%), Croatia (7%), and Finland (8%) . The proportion of hMPV‐positive swabs that were also found to be positive for other respiratory viruses was 9.2%, which is similar to what has been previously reported in epidemiological studies conducted in Japan, Hong Kong and Canada in different combinations of other respiratory viruses .…”

Section: Discussionsupporting

confidence: 89%

Genetic characterization of human metapneumovirus identified through community and facility‐based surveillance of infants in Dhaka, Bangladesh

Rahman

Sumiya

Sahabuddin

et al. 2018

Journal of Medical Virology

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Background Acute respiratory infection (ARI) is a leading cause of morbidity and mortality in children in low and middle‐income countries. Human metapneumovirus (hMPV) is one of the most common viral etiological agents for ARIs in children. Objectives In this study, we explored the genotypic diversity and the epidemiology of hMPV among infants in Dhaka, Bangladesh. Study Design Between December 2014 and August 2016, a total of 3810 mid‐turbinate nasal swab samples were collected from infants (0 to 6 months of age) who met clinical ARI criteria, as a part of a prospective ARI cohort study. hMPV was detected using polymerase chain reaction, and genotyped by sequencing and phylogenetic analysis. Results hMPV was identified in 206 (5.4%) nasal swab specimens. One‐tenth of the hMPV‐positive swabs (n = 19) were also positive for other respiratory viruses. hMPV activity peaked in January and September in 2015; however, no seasonal pattern of hMPV infection was detected. Phylogenetic analyses of the N and F gene‐fragments revealed that the hMPV strains circulating in Dhaka, Bangladesh, belonged to three genotypes: A2b, A2c, and B1. Genotype A (57%) was the predominant hMPV genotype circulating in Bangladesh during the study period. Conclusion This study describes both the epidemiology of hMPV infection and its genotypic strain diversity in Dhaka, Bangladesh.

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“…Although our samples originate from a short period of time (September 2011-January 2014), they distinctly indicate biennial occurrence of HPIV1, as we previously found for respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) in Croatia (Ljubin-Sternak et al, 2014;Mlinarić -Galinovic et al, 2012). Biennial circulation of HPIV1 has also been reported in previous epidemiological studies (Fry et al, 2006;Morgan et al, 2013;Villaran et al, 2014;Wang et al, 2015).…”

Section: Discussionmentioning

confidence: 92%

A study of genetic variability of human parainfluenza virus type 1 in Croatia, 2011–2014

Košutić-Gulija

Slović

Ljubin‐Sternak

et al. 2016

Journal of Medical Microbiology

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Seasonal Occurrence of Human Metapneumovirus Infections in Croatia

Abstract: This study indicates that HMPV infections in Croatia show a biennial outbreak pattern characterized by alternation of winter and spring activity. HMPV outbreaks alternate with respiratory syncytial virus outbreaks.

Cited by 11 publications

References 25 publications

Genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Croatia

Genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Croatia

Genetic characterization of human metapneumovirus identified through community and facility‐based surveillance of infants in Dhaka, Bangladesh

A study of genetic variability of human parainfluenza virus type 1 in Croatia, 2011–2014

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