Seasonal variations in the occurrence of acute myocardial infarction in Hungary between 2000 and 2004

Permanent stress may be the trigger of an acute myocardial infarction on the first work-day of the week

“…However, cyclic occurrence of cardiovascular diseases is not random showing predictable critical periods of daily, weekly or seasonal variation regarding the onset of an event [3][4][5][6][7]. Most biological and physiological functions vary along natural circadian rhythms.…”

“…There are demonstrable strong associations between enlarged LA size and increased risk for stroke, atrial fibrillation and death [2][3][4]. The association between low exercise capacity and poorer prognosis has been established in healthy subjects and in patients with cardiac or pulmonary diseases [5][6][7]. In the absence of left ventricular (LV) systolic dysfunction, coronary artery disease or significant valvular disease, abnormal LV filling may be paramount in limiting exercise capacity [8,9].…”

Is there a geographic variation in the seasonal distribution of acute myocardial infarction and sudden cardiac death?

“…We read with great interest the paper by Kriszbacher et al which was recently published online in the International Journal of Cardiology [1]. In this article, the authors analyzed 81,215 Hungarian patients with acute myocardial infarction (AMI) in order to identify the presence of seasonal and weekly variation.…”

“…However, LMWH cannot inactivate clotbound thrombin which is the major stimulus of thrombosis. Moreover, both heparin variability and resistance may limit optimal anticoagulant therapy with heparin in patients with ACS [1]. Consequently, new drugs with minimal side effects are needed for therapy for UAP.…”

The time of sunrise and the number of hours with daylight may influence the diurnal rhythm of acute heart attack mortality

“…The time of sunrise and the number of hours with daylight may influence the diurnal rhythm of acute heart attack mortality Morbidity and mortality of myocardial infarction (MI) show a seasonal variation, with the highest number of events during winter and spring, and lowest during the summer [1][2][3]. The daily rhythm of MI is also well known with the highest incidence and mortality due in the morning [4][5][6].…”