Seborrheic dermatitis: topical therapeutics and formulation design

Mangion, Sean E.; Mackenzie, Lorraine; Roberts, Michael S.; Holmes, Amy

doi:10.1016/j.ejpb.2023.01.023

Cited by 13 publications

(9 citation statements)

References 119 publications

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“…It has long been known that seasonal variations and geographical differences may influence the lipid content of the skin. 17,38 With or without inflammation, the lipophilic Malassezia genus plays a key role in their pathogenesis, and reduction of these yeasts on the scalp is one of the main therapeutic targets. 3,4,31,37 KTZ, CLZ, and PRT are common agents that are active against TA B L E 1 Studied formulations and their properties.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of novel cosmetic shampoo formulations against Malassezia species: Preliminary results of anti‐dandruff shampoo formulations

Ergin,

Kurt,

Türkoğlu

et al. 2024

J of Cosmetic Dermatology

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ObjectivesMalassezia species are common, clinically relevant, and lipid‐dependent yeasts of humans. They are also the leading causes of the dandruff problem of humans, and the azoles are used primarily in their topical and systemic treatment. Resistance to azoles is an emerging problem among Malassezia sp., which indicates the need of new drug assessments that will be effective against dandruff and limit the use of azoles and other agents in treatment. Among them, the efficacy of various combinations of piroctone olamine and climbazole against Malassezia sp. is highly important. Here, we assessed the efficacies of various piroctone olamine and climbazole formulations against Malassezia sp. in comparison with ketoconazole.MethodsA total of nine formulations were included in the study, where each formulation was prepared from different concentrations of piroctone olamine and climbazole and both. All formulations contained the same ingredients as water, surfactants, hair conditioning agents, and preservatives. Malassezia furfur CBS1878, Malassezia globosa CBS7874, and Malassezia sympodialis CBS9570 were tested for antifungal susceptibility of each formulation by agar diffusion method. Sizes of the inhibition zones were compared with standard medical shampoo containing 2% ketoconazole, and the data were analyzed by Dunnett's multiple‐comparison test.ResultsFor all Malassezia sp. strains, climbazole 0.5% and piroctone olamine/climbazole (0.1%/0.1% and 0.1%/0.5%) combinations were found to have the same effect as the medical shampoo containing 2% ketoconazole. Piroctone olamine/climbazole 1.0%/0.1% formulation showed the same efficacy as 2% ketoconazole on M. furfur and M. sympodialis, while 0.1%/0.5% formulation to only M. furfur. For M. globosa, none of the formulations tested were as effective as ketoconazole.ConclusionThe species distribution of Malassezia sp. varies depending on the anatomical location on the host. According to the results of this study, climbazole and piroctone olamine combinations seem to be promising options against the dandruff problem with their high antifungal/anti dandruff efficacy.

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Section: Discussionmentioning

confidence: 99%

Evaluation of novel cosmetic shampoo formulations against Malassezia species: Preliminary results of anti‐dandruff shampoo formulations

Ergin,

Kurt,

Türkoğlu

et al. 2024

J of Cosmetic Dermatology

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“…Barrier impairment parallels that of atopic dermatitis where emollients are used effectively 69 . Treating SD by improving the skin barrier function has been proposed as a potential adjuvant therapy, 70 but the management of SD remains focussed on anti‐inflammatory and anti‐fungal treatments 71 . Taken together, the incorporation of emollients, humectants or other barrier repair agents should not be neglected in the management of SD and might support current treatment modalities.…”

Section: Discussionmentioning

confidence: 99%

“…Barrier impairment parallels that of atopic dermatitis where emollients are used effectively. 69 Treating SD by improving the skin barrier function has been proposed as a potential adjuvant therapy, 70 but the management of SD remains focussed on anti-inflammatory and anti-fungal treatments. 71…”

Section: Con Clus Ionmentioning

confidence: 99%

Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition

Rousel,

Nădăban,

Saghari

et al. 2023

Experimental Dermatology

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Seborrheic dermatitis (SD) is a chronic inflammatory skin disease characterized by erythematous papulosquamous lesions in sebum rich areas such as the face and scalp. Its pathogenesis appears multifactorial with a disbalanced immune system, Malassezia driven microbial involvement and skin barrier perturbations. Microbial involvement has been well described in SD, but skin barrier involvement remains to be properly elucidated. To determine whether barrier impairment is a critical factor of inflammation in SD alongside microbial dysbiosis, a cross‐sectional study was performed in 37 patients with mild‐to‐moderate facial SD. Their lesional and non‐lesional skin was comprehensively and non‐invasively assessed with standardized 2D‐photography, optical coherence tomography (OCT), microbial profiling including Malassezia species identification, functional skin barrier assessments and ceramide profiling. The presence of inflammation was established through significant increases in erythema, epidermal thickness, vascularization and superficial roughness in lesional skin compared to non‐lesional skin. Lesional skin showed a perturbed skin barrier with an underlying skewed ceramide subclass composition, impaired chain elongation and increased chain unsaturation. Changes in ceramide composition correlated with barrier impairment indicating interdependency of the functional barrier and ceramide composition. Lesional skin showed significantly increased Staphylococcus and decreased Cutibacterium abundances but similar Malassezia abundances and mycobial composition compared to non‐lesional skin. Principal component analysis highlighted barrier properties as main discriminating features. To conclude, SD is associated with skin barrier dysfunction and changes in the ceramide composition. No significant differences in the abundance of Malassezia were observed. Restoring the cutaneous barrier might be a valid therapeutic approach in the treatment of facial SD.

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“…These cosmetics are in the form of a cream, lotion, body milk, or occasionally even as fluid for normal, dry, or oily skin. [1][2][3] Emulsions are typically used as cosmetic formulations due to their high ability of skin penetration, easy wash off, and variable viscosity. 4 Various pharmaceutical preparations used in the management of chronic skin diseases are formulated as emulsion systems.…”

Section: Introductionmentioning

confidence: 99%

“…The bases for skincare formulations for both healthy and diseased skin are a variety of cosmetic emulsions. These cosmetics are in the form of a cream, lotion, body milk, or occasionally even as fluid for normal, dry, or oily skin 1–3 . Emulsions are typically used as cosmetic formulations due to their high ability of skin penetration, easy wash off, and variable viscosity 4 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication, organoleptic evaluation and in vitro characterization of cream loaded with Carica papaya seed extract

Sarfraz,

Shabbir,

Adnan

et al. 2023

J of Cosmetic Dermatology

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ObjectiveThe current study aimed to provide preliminary insights into potential biopharmaceutical applications of Carica papaya seed extract by evaluating its phytochemical and biological profiles. Furthermore, the study aimed to develop a stable oil‐in‐water (O/W) emulsion for the effective delivery of antioxidant‐rich biologicals for cosmetic purposes.MethodsThe hydroethanolic (ethanol 80%: 20% water) extract of C. papaya seeds was prepared via maceration technique. The chemical composition was carried out through preliminary phytochemical screening and estimation of total phenolic contents (TPC) and total flavonoid contents (TFC). The biological profile of the extract was explored using various in‐vitro antioxidant methods. The homogenization procedure was used to create a cream of O/W and various tests were applied to assess the stability of the emulsion. By keeping the emulsion at different storage conditions (8 ± 0.5°C, 25 ± 0.5°C, 40 ± 0.5°C, and 40 ± 0.5°C ± 75% relative humidity [RH]) for a period of 28 days), the physical stability parameters of the emulsion, including pH, viscosity, centrifugation, phase separation, and conductivity, as well as rheological parameters and organoleptic parameters (odor, color, liquefaction, and creaming), were assessed.ResultsThe preliminary phytochemical screening assay revealed the presence of various plant secondary metabolites including alkaloids, phenolics, flavonoids, tannins, saponins, and quinones. The extract was found to be rich in TPC and TFC. The in vitro antioxidant study gave maximum activity in the DPPH method. The plant extract containing cosmetic cream exhibited remarkable stability during the entire research. Data gathered indicated that no phase separation or liquefaction was seen after the experimental period. Throughout the experimental period, a small variation in the pH and conductivity values of the base and formulation was seen.ConclusionThe findings suggest that the seed extract of C. papaya is a rich source of polyphenols with antioxidant potential and can be a promising alternative for the treatment of various ailments. The stability of emulsion paves the way for its utilization as a carrier for the delivery of 3% C. papaya seed extract and applications in cosmetics products.

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Seborrheic dermatitis: topical therapeutics and formulation design

Cited by 13 publications

References 119 publications

Evaluation of novel cosmetic shampoo formulations against Malassezia species: Preliminary results of anti‐dandruff shampoo formulations

Evaluation of novel cosmetic shampoo formulations against Malassezia species: Preliminary results of anti‐dandruff shampoo formulations

Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition

Fabrication, organoleptic evaluation and in vitro characterization of cream loaded with Carica papaya seed extract

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