Second Malignancies in Patients with Multiple Myeloma

Law, Ivan P.; Blom, Johannes

doi:10.1159/000225175

Cited by 53 publications

(18 citation statements)

References 8 publications

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“…reported that, in 1027 patients diagnosed with multiple myeloma, the proportion of secondary hematologic malignity was 0.7% and the proportion secondary solid malignancy was 1.9% [8]. As we mentioned earlier, malignancies synchronized with multiple myeloma have been reported before [1][2][3][4][5]. But it was not included medullary thyroid carcinoma which occurs extremely rare, to our knowledge there are no prior reports of this case.…”

Section: Discussionmentioning

confidence: 67%

“…The co-existence multiple myeloma and another cancer such as renal cell carcinoma, lung, gastric carcinoma, colon, prostate, breast, bladder, uterus, and liver have been reported severally in literature [1][2][3][4][5], but medullary thyroid carcinoma (MTC) as a second malignancy with multiple myeloma is an extremely rare case which seems has not been reported before, here we are presenting a case with these two types of cancer. A 54-year-old male with diabetes history presented on 17th November 2013 with complaints of severe bone pain on his shoulder and vomiting.…”

Section: Introductionmentioning

confidence: 98%

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Medullary thyroid carcinoma associated with multiple myeloma: A case report

Mortazavizadeh¹,

Ayoughi²,

Binesh³

et al. 2016

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Case Report: A 54-year-old man was admitted with chief complain of bone pain, clinical investigation revealed, lytic bone lesions and infiltration of plasma cells in bone marrow and patient with diagnosis of multiple myeloma received chemotherapy, he was in partial remission, but nine months later a solitary nodule was founded in his thyroid, with high levels of calcitonin and fine needle aspiration (FNA) reported the medullary thyroid carcinoma, after total thyroidectomy which confirmed this cancer the patient recovered and now he is followed-up for these cancers. Conclusion: Diagnosis of secondary cancer is important because: first to distinguish secondary malignancy from metastatic cancer and then try to investigate the etiology of this association. IJCRI publishes Review

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 98%

Medullary thyroid carcinoma associated with multiple myeloma: A case report

Mortazavizadeh¹,

Ayoughi²,

Binesh³

et al. 2016

IJCRI

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“…Although the immune deficiencies forming part of the original pathologic process in patients with multiple myeloma or AIDS may also predispose them to secondary malignancies [22,23], there is no solid evidence that immune deficiency caused by NHL is a predisposing factor for AML. In the present case, firm evidence was also lacking that AML blasts and lymphoma cells had the same origin, since chromosomal analysis of the lymphoma cells was not successful.…”

Section: Discussionmentioning

confidence: 99%

Effect of <i>L</i>-Asparaginase Combined with Vincristine and Prednisolone on Acute Myeloblastic Leukemia (M0) Associated with Non-Hodgkin Lymphoma

Horikoshi

Takei²,

Iriyama³

et al. 2009

Acta Haematol

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A 66-year-old Japanese woman was referred to us because of severe anemia and fever and presented at our hospital. She was eventually diagnosed as having acute myeloblastic leukemia (AML; M0) with non-Hodgkin lymphoma (NHL). We investigated the therapeutic efficacy of L-asparaginase (L-Asp), vincristine and prednisolone for both her AML and NHL. Asparagine synthetase (AS) activity in her AML blast cells was undetectable. A lymph node biopsy specimen revealed NHL of the marginal zone B cell type. Complete remission (CR) of AML and NHL was achieved. CR of the AML lasted for 18 months without further consolidation therapy. We conclude that L-Asp can be an effective drug for the treatment of AML in which blasts are negative for AS.

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“…The relation of multiple myeloma with gastric MALT type lymphomas [248][249][250][251][252][253][254] was identified many years before H. pylori was known. Today, it is known that in MALT lymphoma, H. pylori antigens can also stimulate plasma cells.…”

Section: Plasma Cell Dyscrasiasmentioning

confidence: 99%

Helicobacter pylori and Hematologic Diseases

Campuzano-Maya¹

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

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Helicobacter pylori infection is the most common infection of the human species, with developing countries displaying a marked disadvantage in contrast to developing countries. While H. pylori infection is asymptomatic in most infected individuals, it is intimately related to malignant diseases of the stomach, such as gastric cancer and gastric MALT lymphoma, as well as benign diseases, for example chronic gastritis and duodenal and gastric peptic ulcers. Since the discovery that gastric mucosa could be colonized by bacteria, evidence of greater than 50 extragastric manifestations has been reported, linking H. pylori infection and the development of diseases associated with cardiology, dermatology, endocrinology, obstetrics and gynecology, hematology, pneumology, neurology, odontology, ophthalmology, otorhinolaryngology, and pediatrics. This chapter presents the extragastric manifestations of H. pylori infection expressed through hematologic diseases; particularly those included in the international consensus, and discusses guidelines for the management of H. pylori infection, such as iron deficiency, vitamin B 12 (cobalamin) deficiency, and immune thrombocytopenia. Other manifestations reviewed include immune neutropenia, antiphospholipid syndrome, and plasma cell dyscrasias, such us monoclonal gammopathy of undetermined significance, multiple myeloma, and Henoch-Schönlein purpura.

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Second Malignancies in Patients with Multiple Myeloma

Cited by 53 publications

References 8 publications

Medullary thyroid carcinoma associated with multiple myeloma: A case report

Medullary thyroid carcinoma associated with multiple myeloma: A case report

Effect of <i>L</i>-Asparaginase Combined with Vincristine and Prednisolone on Acute Myeloblastic Leukemia (M0) Associated with Non-Hodgkin Lymphoma

Helicobacter pylori and Hematologic Diseases

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