Second Malignant Neoplasm in Treated Hodgkin's Disease

Takaue, Yoichi; Sullivan, Margaret P.; Ramírez, Isabel; Cleary, Karen R.; Eys, Jan Van

doi:10.1001/archpedi.1986.02140150051032

Cited by 12 publications

(2 citation statements)

References 25 publications

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“…42 Curiously, as this case, a patient with Hodgkin's disease as one of 5 distinct malignant neoplasms has been reported, 13 as has a patient with gliosarcoma developing after Hodgkin's disease. 43 …”

Section: Pathogenesismentioning

confidence: 99%

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Welsh¹,

Thurman²,

Howard³

2003

Clinical Medicine & Research

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The presence of five discrete synchronous or metachronous primary neoplasms in a single patient is an extremely rare event. This is a report of a patient with a malignant (invasive) thymoma and four other independent primary neoplasms including: gliosarcoma, papillary thyroid cancer, meningioma and metastatic adenocarcinoma of the colon, found synchronously at autopsy. Thymoma patients appear to have an inherent predisposition towards developing additional neoplasms. Other than the thymoma, the presented patient had no obvious risk factors for neoplasia. This case provides evidence for an unusual syndrome of thymoma and multiple primary neoplasms. Further research is required to elucidate the mechanism of this association. Meanwhile, heightened awareness of this association may allow earlier detection and treatment of additional cancers in patients with a history of thymoma.

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Section: Pathogenesismentioning

confidence: 99%

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Welsh¹,

Thurman²,

Howard³

2003

Clinical Medicine & Research

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“…These second malignant [1][2][3][4][5]7401 but no reports of large series concerning the risk to children. A small series and individual cases of SMN in children have been reported, but the paucity of childhood cases followed for long enough periods precluded an organized attempt to estimate the probability of SMN in children and to study the etiologic effects of therapy [22][23][24][25]. In view of the long life-expectancy of children following cure for malignant disease, it is important to determine what that risk is in young patients, to identify factors that modify the risk, and to describe the ways in which children and adults may differ.…”

Section: Discuss 1 0 Nmentioning

confidence: 99%

Second malignant neoplasms following childhood Hodgkin's disease: Treatment and splenectomy as risk factors

Meadows

Obringer

Marrero

et al. 1989

Med. Pediatr. Oncol.

145

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The risk of second malignant neoplasm (SMN) was evaluated in 979 children with Hodgkin's disease. This cohort was diagnosed between 1955 and 1979 at one of the institutions of the Late Effects Study Group. Solid tumors, non-lymphocytic leukemia, and non-Hodgkin's lymphoma (NHL) developed in 18, 17, and 3 patients, respectively. The estimated cumulative probability of developing any SMN was 2% at 5 years from diagnosis, 5% at 10 years, and 9% at 15 years. The incidence is ninefold greater than the risk of acquiring cancer in 19 year-olds, the median age at which the diagnosis of SMN was made in this study population.For leukemia and NHL the corresponding probabilities were 1%, 3%, and 4% for the group as a whole but were increased (2%, 6%, and 8%) in patients who had suffered one or more recurrences. In order to analyze the risk of leukemia and NHL associated with alkylating agent chemotherapy, each patient was assigned a score of one for each alkylating agent administered for a 6-month period. Scores of 2, 4, 6, and 8 were associated with probabilities of leukemia or NHL of 2%, 3%, 6%, and lo%, respectively.In a multivariate analysis for leukemia/lymphoma that included AAD score, stage, and splenectomy, the effect of AAD score and splenectomy did not change substantially compared to the univariate results. AAD score remained statistically significant ( P = .OOOli, and splenectomy was of borderline significance ( P = ,139).Ot the 18 solid tumor SMNs, 15 developed within the field of radiation, and one other developed in tissue irradiated 34 years earlier for hemangoma.This study of a large and unselected group of children with Hodgkin's disease who received a variety of therapies demonstrates that children are as likely as adults to develop acute leukemia after alkylating agents and solid tumors in the field of radiation therapy.

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Late Effects in Children With Cancer

Hutter¹

1986

Am J Dis Child

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Second Malignant Neoplasm in Treated Hodgkin's Disease

Cited by 12 publications

References 25 publications

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Thymoma and Multiple Malignancies: A Case of Five Synchronous Neoplasms and Literature Review

Second malignant neoplasms following childhood Hodgkin's disease: Treatment and splenectomy as risk factors

Late Effects in Children With Cancer

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