Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

Abstract

Purpose To examine the incidence of secondary primary malignancies in patients with renal cortical neoplasms. Methods Between January 1989 and July 2010, 3647 patients underwent surgery at our institution for a renal cortical neoplasm and were followed through 2012. Occurrence of other malignancies was classified as antecedent, synchronous, or subsequent. All patients with antecedent malignancies (n = 498) and a randomly selected half of those with synchronous malignancies (n = 83) were excluded. The expected number of second primaries was calculated by multiplying Surveillance, Epidemiology, and End Results Program incidence rates of renal cortical neoplasms by person-years at risk within categories of age, sex, and year of diagnosis. The standardized incidence ratio (SIR) was calculated as observed cancers divided by expected incidence of the cancer, with approximation to the exact Poisson test used to obtain confidence intervals (CI) and p values. Results Of 3066 patients with renal cortical neoplasms, 267 had a second primary cancer; the five most common in men were prostate, colorectal, bladder, lung, and non-Hodgkin’s lymphoma; the five most common in women were breast, colorectal, lung, endometrium, and thyroid. Men demonstrated higher than expected thyroid cancer rate (SIR 5.0; 95 % CI 1.83–10.88, p = 0.002), and women had higher than expected rates of stomach cancer (SIR 5.0; 95 % CI 1.61–11.67, p = 0.004) and thyroid cancer (SIR 4.62; 95 % CI 1.69–10.05, p = 0.003). Conclusions The incidence of certain types of second malignancies may be higher in patients after diagnosis of renal cortical neoplasms compared to the general population. These observations can inform clinical follow-up in kidney cancer survivorship and future research studies.

Robot-assisted Partial Nephrectomy: 5-yr Oncological Outcomes at a Single European Tertiary Cancer Center

“…Lane et al [21] reported DFS of 96.9% and 92.3% in LPN and open PN subgroups, respectively, in patients with minimum 5-yr follow-up. The DFS rate in our cohort was slightly inferior compared with the mentioned series, but it has to be emphasized that OS in our series is 95.1% despite 29% patients having a history of another neoplasia [24]. Moreover, the follow-up schedule in our patients included lung CT, which was not routinely performed in other series [10,11].…”

Deciphering the Risk of Developing Second Primary Thyroid Cancer Following a Primary Malignancy—Who Is at the Greatest Risk?

“…A total of 40 articles (33 retrospective cohorts, 5 retrospective case-controls and 2 prospective cohorts) including 1,613,945 cancer patients with 15 distinct primary cancers were included in the analysis [ 5 , 7 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. The study characteristics are shown in Table 1 .…”

Risk of second primary breast cancer among cancer survivors: Implications for prevention and screening practice

“…The kidney-breast cancer link was inconsistent in previous publications. Murray et al recently found a lower than expected rate of BC in renal cortical neoplasms using a 90 day of latency [37]. While a study based on the European Prospective revealing an excessive risk of kidney cancer among BC survivors [38].…”