Second primary molar hypomineralisation and drugs used during pregnancy and infancy. A systematic review

Muñoz, Clara; Ruiz, Antonio José Ortiz; Silva, Amparo Pérez; González, Luis Alberto Bravo; Vicente, Ascensión

doi:10.1007/s00784-019-03007-7

Cited by 14 publications

(10 citation statements)

References 29 publications

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“…In view of this fact, the 14 children who presented HSPM should be monitored until the eruption of the first molars and permanent incisors because they are highly likely to present HMI, since the enamel mineralization phase of these teeth occurs in the same period 15,19 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predisponent factors of molar-incisor hypomineralization in primary dentition

Lira

Sousa

et al. 2021

Braz. J. Oral Sci.

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Aim: To evaluate the prevalence and predisposing factors for hypomineralization of second molars in children in primary dentition. Methods: A questionnaire was applied to parents to analyze predisposing factors and to assist in the diagnosis of hypomineralization in children between 2 and 6 years old, followed by an intraoral examination based on indices of non-fluorotic enamel defects in the primary dentition, according to the “Modified Index DDE” to determine demarcated opacity and HSPM presence / severity index to assess hypomineralization. Children from public and private schools were dived into two groups: if they presented HSPM-Group 1 (G1) and if they did not have HSPM-Control group (CG). Results: The most frequent predisposing factors associated with the child were Illness in the first year of life (X2= 6.49; p=0.01) and antibiotic use in the first year of life (X2= 41.82; p= 0.01). The factors associated with the mother were hypertension (X2= 9.36; p=0.01), infections during pregnancy (X2=14.80; p=0.01) and alcohol consumption during pregnancy (X2=97.33; p=0.01). There was a prevalence of 3.9% of HSPM in 14 children, with statistical difference regarding gender (X2 = 4.57; p <0.05), with boys presenting a higher frequency. In G1 hypomineralization was of the type with demarcated opacity, with more prevalent characteristics the yellowish spot, with moderate post-eruptive fracture and acceptable atypical restorations. All lesions were located in the labial region with 1/3 of extension. Conclusion: The prevalence of HSPM in children between 2 and 6 years old was 3.9%, with a predominance in males, with tooth 65 being the most affected. There was an association between HSPM and infection in the first year of life, as well as the use of antibiotics and sensitivity in the teeth affected by the lesion. There was an association between HSPM and hypertension, infection and mothers' alcohol use during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Prevalence and predisponent factors of molar-incisor hypomineralization in primary dentition

Lira

Sousa

et al. 2021

Braz. J. Oral Sci.

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“…This allows a mapping chronological timeframe (Figure 2) and a classification by putative biological mechanisms (Figure 3). Some factors are well-reported and have been the subject of review papers (not analyzed in this SC): severe respiratory distress syndromes (146), preterm birth (147), vitamin D deficiencies during childhood (148), cleft palate (149), syphilis (150), excess fluoride (151), renal disorders (133), diabetes type 1 (152), cancer therapy (153), organic pollutants (154), dioxin exposure (155), dietary components (156), drugs during pregnancy and the first year of life (157), and drugs during infancy (158); these do not always relay clear evidence between DDE and risk factors supporting our hypothesis of accumulation and synergy effects. Generalist reviews were found, but either did not identify as many factors in a systematic way (159), or focused on one type of DDE (160), dentition (161) or treatment (162).…”

Section: Highlight the Current Literature And Better Understand The N...mentioning

confidence: 99%

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

et al. 2022

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BackgroundDevelopmental Defects of Enamel (DDE) is a pathology of the teeth that can greatly alter the quality of life of patients (hypersensitivity, esthetic issues, loss of function, etc.). The acquired DDE may occur as a result of a wide range of acquired etiological factors and his prevalence of this pathology may reach up to 89.9%. The main objective of this research was to identify and analyze, in current literature, the factors related to acquired DDE, in order to propose a general theory about the mechanisms involved.MethodsThe search of the primary literature was conducted until [December 31, 2021]. Our search strategy uses the Pubmed/MEDLINE database and was structured around 3 terms [“Development,” “Defect,” and “Enamel”]. To be included, references had to be primary studies, written in English. Exclusion criteria were reviews, in vitro, animal, genetic or archeology studies, and studies focused on clinical management of DDE. One hundred and twenty three articles were included in this scoping review: 4 Randomized clinical trials, 1 letter, 5 cases reports, 2 fundamentals studies, and 111 observational studies (33 Cross-sectional studies, 68 Cohort study and 10 Case-control study). The quality of evidence was assessed using the PEDro scale for clinical trials, the Newcastle-Ottawa scale for observational studies, and a published tool to assess the quality of case reports and case series.ResultsA scoping review of the literature identified 114 factors potentially involved in acquired DDE. The most frequently encountered pathologies are those causing a disorder of calcium homeostasis or a perturbation of the ARNT pathway in mother or child. The link between the ARNT pathway and metabolism deficiency in uncertain and needs to be defined. Also, the implication of this mechanism in tissue impairment is still unclear and needs to be explored.ConclusionsBy identifying and grouping the risk factors cited in the literature, this taxonomy and the hypotheses related to the mechanism allow health practitioners to adopt behaviors that limit the risk of developing aDDE and to set up a prevention of dental pathology. In addition, by reviewing the current literature, this work provides guidance for basic research, clinical studies, and literature searches.

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“…por lo que una anamnesis minuciosa en el control prenatal o durante la primera consulta odontológica del bebé puede arrojar datos que nos lleven a orientar y alertar a los responsables y también integrar esta información para asociarla con las posibles causas del aparecimiento de estos defectos al momento de la erupción dentaria. 45 Entre otros factores asociados, Souza JF, et al en 2016, 33 sugiere un vínculo entre HMI y problemas de salud durante el embarazo, así como factores ambientales. Coincidiendo con un estudio realizado por Fatturi AL et al en 2019, 42 donde se establece que el período prenatal y el estrés psicológico durante la gestación se asoció con HMI, este metanálisis mostró que los niños cuyas madres tuvieron problemas de salud durante la gestación presentaron un 40% más de probabilidades de HMI que los hijos de madres que no tuvieron problemas en la gestación.…”

Section: Período Prenatalunclassified

Alteraciones sistémicas asociadas a Hipomineralización Molar Incisivo (HMI). Una revisión de literatura.

García¹,

Escobar²,

Reyes³

et al. 2022

Rev. Odontopediatr. Latinoam.

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Resumen. El término Hipomineralización molar incisivo (HMI) fue sugerido por la Academia Europea de Odontología Pediátrica (EAPD) para referirse a este como un defecto específico del desarrollo del esmalte. La HMI es un defecto del esmalte dentario ampliamente estudiado, pero hasta la fecha los factores de riesgo no son concluyentes, sin embargo, se considera de origen sistémico y multifactorial, presentando una prevalencia variada del 2.9–44% reportada en estudios recientes. Las implicaciones sistémicas pueden acontecer en periodos específicos (pre, peri y posnatal) considerados importantes y críticos en el desarrollo de la vida humana. Objetivo: aportar la mejor evidencia científica disponible sobre los factores sistémicos asociados a la Hipomineralización Molar Incisivo. Materiales y métodos: Se realizó una búsqueda sistematizada seleccionando estudios primarios en bases de datos electrónicas: Pub Med, biblioteca Cochrane e Hinari a través de la pregunta PICO. Resultados: 115 estudios fueron identificados a través de la búsqueda electrónica de estos solo 18 fueron elegibles según los criterios de inclusión. Conclusión: Existe una amplia evidencia de las implicaciones sistémicas que se asocian a HMI, sin embargo, no son del todo concluyentes por lo que los resultados deben ser analizados con prudencia considerando futuras investigaciones. Entre ellos resaltan: complicaciones en el embarazo, fiebres altas, hipertensión arterial, diabetes gestacional, procesos infecciosos, uso frecuente de antibióticos y desnutrición, así como parto prematuro, bajo peso al nacer, las enfermedades respiratorias, fiebre y otitis en los primeros años de vida del niño.

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Second primary molar hypomineralisation and drugs used during pregnancy and infancy. A systematic review

Cited by 14 publications

References 29 publications

Prevalence and predisponent factors of molar-incisor hypomineralization in primary dentition

Prevalence and predisponent factors of molar-incisor hypomineralization in primary dentition

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

Alteraciones sistémicas asociadas a Hipomineralización Molar Incisivo (HMI). Una revisión de literatura.

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