Second trimester abortion using intravaginal misoprostol

A systematic review of the effectiveness, safety, and acceptability of medical management of intrauterine fetal death at 14–28 weeks of gestation

“…Five trials compared different dosages of misoprostol and included comparisons of 100 μg versus 200 μg, 200 μg versus 400 μg, and 400 μg versus 600 μg (Table ).…”

“…One trial compared two doses of misoprostol, 600 μg versus 400 μg, administered vaginally every 12 hours . The 600 μg dose was slightly more effective in terms of completeness within 24 hours (RR 0.90; 95% CI, 0.8–1.0) but within 48 hours there may be little to no difference (RR 0.98; 95% CI, 0.93–1.04).…”

“…Eighty-three full texts were screened, of which 67 were excluded. Six additional trials [13][14][15][16][17][18] identified from three systematic reviews 6-8 were included. We contacted the authors of included trials where additional information was needed.…”

Mort fœtale in utero au-delà de 14SA : induction du travail et obtention de la vacuité utérine

“…Comme les donné es de niveau de preuve é levé sont rares, notre analyse de la litté rature a tenu compte des ré sultats d'é tudes prospectives non randomisé es et ré trospectives bien mené es. La mé thodologie et les ré sultats des principales é tudes comparatives sont ré sumé s dans le Tableau 1 [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”

“…L'efficacité et l'innocuité des procé dures mé dicales en fonction de l'é tat foetal (vivant ou dé cé dé ) ont é té trè s peu é valué es [19,28,32,34,37]. Malgré un dé lai induction-expulsion souvent plus court, les donné es sont actuellement insuffisantes pour dire que l'efficacité des protocoles mé dicaux d'induction du travail est modifié e en cas de MFIU.…”