Second trimester angiotensing-converting enzyme and uterine artery Doppler as predictors of preeclampsia in a high-risk population

Martínez-Ruiz, Ana; Sarabia-Meseguer, María Desamparados; Vı́lchez, Juan Antonio; Pérez-Fornieles, Joaquín; Delgado-Marín, Juan Luis; Tovar-Zapata, Isabel; Noguera-Velasco, José Antonio

doi:10.3109/10641955.2014.988352

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…When ACE is over‐expressed due to genetic factors, RAS will be overactive and the function of prostaglandin (PG) system will be disordered, resulting in vasoconstriction, which plays a certain role in the pathogenesis of pre‐eclampsia. Ruiz et al 9 . reported that serum ACE levels in pregnant women with pre‐eclampsia were significantly higher than those without pre‐eclampsia.…”

Section: Introductionmentioning

confidence: 99%

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

Liu

2020

J of Obstet and Gynaecol

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Aim In recent years, there were many studies on angiotensin‐converting enzyme insersion/delection (ACE I/D) polymorphism and pre‐eclampsia susceptibility, but the conclusion was still inconclusive. Our study is to explore the relationship between the ACE I/D polymorphism and the risk of pre‐eclampsia. Methods The literature on the relationship between ACE I/D gene polymorphism and Pre‐eclampsia susceptibility was obtained by searching the databases of Wanfang, VIP, Medline, CNKI, Embase, Pubmed and Springerlink, which was published from the establishment of the databases to October 2019. Taking the odds ratio (OR) value and its 95% confidence interval (CI) as the effect size, the Meta‐analysis was carried out by using stata 15.0 software. Results Thirty articles, consisting of 3184 patients and 3912 controls, were included. The results showed that allele D was compared with allele I, with the OR value of 1.29 (95% CI: 1.12 ~ 1.50, P < 0.05). Subgroup analysis showed that in Caucasians, allele D was associated with OR of 1.28 (95% CI: 1.08 ~ 1.53, P < 0.05). There was no significant difference in Asians. There was statistical significance in recessive gene model and homozygous gene model, as well as in that of Asian and Caucasian. In homozygous model, there was statistical significance, but subgroup analysis showed there was no statistical significance in Asian and Caucasian. There was no statistical significance in dominant model and heterozygous model. Conclusion The polymorphism of ACE I/D gene was associated with the risk of pre‐eclampsia. Allele D and genotype DD may increase the risk of Pre‐eclampsia in pregnant women.

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Section: Introductionmentioning

confidence: 99%

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

Liu

2020

J of Obstet and Gynaecol

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“…Preeclampsia risk factors include obesity, insulin resistance, and hyperlipidemia, which can stimulate the release of inflammatory and oxidative stress, leading to endothelial dysfunction 4 . In preeclampsia, there was abnormal invasion of trophoblast cells and destruction of the physiological remodeling of the uterine spiral artery into uterine placental vessels observed in normal pregnancy 5 , 6 . Severe preeclampsia may be associated with thrombocytopenia, multiple organ damage, and fetal growth restriction 7 .…”

Section: Introductionmentioning

confidence: 99%

Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia

Liu

Ding

et al. 2023

Cell Transplant

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We aimed to explore whether the effect of progesterone on preeclampsia via the PI3K/AKT signaling pathway. First, we studied the role of progesterone in preeclampsia patients and HTR-8/Svneo cells by adding progesterone. Then PI3K inhibitor LY294002 was added. The effects of progesterone on preeclampsia were also studied in animals by constructing a preeclampsia rat model. CCK-8 and Transwell assay were applied to measure cell viability and invasion ability. ELISA was performed to measure progesterone, MMP-2, MMP-9, pro-inflammatory factors TNF-α, IL-1β, and anti-inflammatory factors IL-4, IL-10, and IL-13 levels. HE staining was used to detect the pathological changes in uterine spiral artery. Western blot was performed to detect Cyclin D1, PCNA, MMP-2, MMP-9, inflammatory factors TNF-α, IL-1β, IL-4, IL-10, IL-13, and PI3K/AKT signaling pathway related proteins AKT, p-AKT, PI3K, and p-PI3K expressions. Progesterone could reduce blood pressure and urine protein in pregnant women with preeclampsia. TNF-α and IL-1β levels were decreased, but IL-4, IL-10, IL-13, cyclin D1, and PCNA levels were increased in pregnant women with preeclampsia after using progesterone. After the use of progesterone, the symptoms of the PE model group were improved. Among them, the lumen of the placental uterine spiral artery was enlarged, and the fibrinoid necrosis of the uterine wall and acute atherosclerotic lesions were relieved. In addition, progesterone promoted HTR-8/Svneo cells proliferation and invasion. However, high expression of MMP-2, MMP-9, p-AKT, and p-PI3K in Normal and preeclampsia groups caused by progesterone was weakened after adding LY294002, indicating that progesterone could activate PI3K/AKT signaling pathway to regulate HTR-8/Svneo cells. Progesterone decreased urine protein and blood pressure of preeclampsia rats in a concentration-dependent manner. Moreover, progesterone activated the PI3K/AKT signaling pathway and inhibited the inflammatory response in preeclampsia rats.

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Uterine arteries pulsatility index by Doppler ultrasound in the prediction of preeclampsia: an updated systematic review and meta-analysis

Liu,

Xie,

Huang

et al. 2023

Arch Gynecol Obstet

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Second trimester angiotensing-converting enzyme and uterine artery Doppler as predictors of preeclampsia in a high-risk population

Abstract: ACE, PI and RI as parameters of Doppler study were useful predictors of PE in the second trimester of gestation. The best combination to increase the diagnostic performance was ACE with the RI.

Cited by 5 publications

References 17 publications

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

Meta‐analysis of angiotensin‐converting enzyme insersion/delection polymorphism and pre‐eclampsia susceptibility

Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia

Uterine arteries pulsatility index by Doppler ultrasound in the prediction of preeclampsia: an updated systematic review and meta-analysis

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