Second Trimester Fetal and Maternal Epicardial Fat Thickness in Gestational Diabetic Pregnancies

Yavuz, And; Akkurt, Mehmet Özgür; Yalçın, Serenat Eriş; Karakoç, Gökhan; Varol, Ercan; Sezi̇k, Mekin

doi:10.1055/s-0042-111435

Cited by 22 publications

(26 citation statements)

References 25 publications

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“…Fetuses of diabetic mothers have significantly greater EFT than fetuses of nondiabetic mothers between 20 and 28 weeks' gestation . Subsequently, Yavuz et al postulated similar alteration in fetuses of mothers with gestational diabetes . Their measurement technique was not standardized, and both studies compared EFT without considering contributing factors such as BMI of mother and gestational age of the fetus.…”

Section: Discussionmentioning

confidence: 99%

“…8 Subsequently, Yavuz et al postulated similar alteration in fetuses of mothers with gestational diabetes. 9 Their measurement technique was not standardized, and both studies compared EFT without considering contributing factors such as BMI of mother and gestational age of the fetus. As it is possible that fetuses of obese mothers have increased epicardial fat related to increased insulin resistance (ie, not related to a diagnosis of diabetes), accounting for BMI is important.…”

Section: Discussionmentioning

confidence: 99%

“…Advances in ultrasound technique allow accurate identification and measurement of fetal EFT. Preliminary studies have shown that EFT is increased in fetuses of mothers with both pregestational (PDM) and gestational diabetes (GDM) . These studies were limited by small sample size, limited gestational age range, and the lack of standardized measurement method.…”

Section: Introductionmentioning

confidence: 99%

“…Preliminary studies have shown that EFT is increased in fetuses of mothers with both pregestational (PDM) and gestational diabetes (GDM). 8,9 These studies were limited by small sample size, limited gestational age range, and the lack of standardized measurement method. Results were not controlled by degree of maternal obesity or gestational age.…”

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confidence: 99%

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Increased fetal epicardial fat thickness: A novel ultrasound marker for altered fetal metabolism in diabetic pregnancies

Akkurt

Turan

Crimmins

et al. 2018

J of Clinical Ultrasound

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Increased fetal epicardial fat thickness: A novel ultrasound marker for altered fetal metabolism in diabetic pregnancies

Akkurt

Turan

Crimmins

et al. 2018

J of Clinical Ultrasound

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show abstract

“…To date, scienti c literature offers very limited information on the ontogenesis of EPI, and not least implications of early life malnutrition on this tissue in comparison with the previously mentioned adipose tissues. In human fetuses, EPI was detected as early as 20-28 weeks of gestation [31,32].…”

Section: Persistent Effects Of Fetal Programming On Functional Traitsmentioning

confidence: 99%

Depot and sex-specific implications for adipose tissue expandability and functional traits in adulthood of late prenatal and early postnatal malnutrition in a precocial sheep model

Ahmad

Lyngman

Mansouryar

et al. 2020

Preprint

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Background Early life malnutrition in the prenatal and postnatal life is well recognized to have long-term implications on the development of offspring and neonate key metabolic organs and their function including adipose tissue later in life. Therefore, the aim of this study was to evaluate the effect of malnutrition in prenatal and early postnatal life on the expandability and functional traits of adipose tissues in adulthood. Twin-pregnant ewes were fed NORM (~ requirements), LOW (50% of NORM) or HIGH (150% and 110% of energy and protein, respectively) diets the last 6 weeks pre-partum (term ~ 147-days). Lambs received moderate, low fat (CONV) or high-carbohydrate-high-fat (HCHF) diets from 3-days until 6-months of age and thereafter CONV diet. At 2½ years of age, histomorphometric and gene expression patterns were characterized in subcutaneous (SUB), perirenal (PER), mesenteric (MES) and epicardial (EPI) adipose tissue.Results SUB had sex-specific (males < females) upper-limits for adipocyte size and cell-number-indices, irrespective of early life nutrition. PER mass and contents of adipocytes were highest in females and HIGH males while adipocyte cross sectional area was lowest in LOW males. Pre- and postnatal nutrition affected gene expression sex-specifically in SUB and PER, but unrelated to morphological changes. In PER, LOW/LOW males were specific targets of gene expression changes. The EPI was affected by postnatal nutrition as HCHF sheep had enlarged adipocytes and upregulated expressions for adipogenic and lipogenic genes.Conclusion Upper-limits for SUB expandability were markedly lower in males. Major targets for prenatal malnutrition were PER and males. LOW males had the lowest PER expandability, whereas HIGH males had an adaptive advantage observed as increased hypertrophic ability equivalent to females. Fixed expandability in SUB meant PER became a determining factor for ectopic fat deposition, rendering LOW males particularly predisposed for obesity-associated metabolic risks. EPI, in contrast to other adipose tissues, was a particular target of early postnatal obesity, resulting in adipocyte hypertrophy in adulthood.

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A new Doppler index, cerebro‐placental‐uterine ratio, and fetal cardiac parameters in early onset preeclampsia

Oğuz,

Ağaoğlu,

Ulusoy

et al. 2024

J of Clinical Ultrasound

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ObjectiveOur aim was to investigate the significance of cerebro‐placento‐uterine ratio CPUR, a new Doppler index, and fetal cardiac parameters (Mod MPI, EFT) in early–onset preeclampsia (EOPE) and to examine whether these parameters are related to perinatal outcome.Study designForty participants diagnosed with EOPE (preeclampsia cases diagnosed before 34 weeks of gestation) and 40 healthy pregnant women were included in this study. Demographic data were recorded. Doppler parameters such as middle cerebral artery (MCA), umbilical artery (UA), and uterine artery (Ut‐A), and left modified myocardial performance index (Mod–MPI) and epicardial fat thickness (EFT) were measured. Cerebroplacental ratio (CPR) was determined by dividing MCA pulsatility index (PI) by UA PI. CPUR was calculated as the ratio of CPR to mean UtA–PI (CPUR = CPR/UtA–PI). All parameters were compared between the EOPE and control groups. Correlation tests were used to examine the relationship between Doppler parameters and perinatal outcome. p values less than 0.05 were considered statistically significant.ResultsThe pulsatility index of the middle cerebellar artery, CPUR and CPR values were statistically lower in the EOPE group than in the control group (p = 0.002; p = <0.001; p = <0.001; respectively). No statistical differences were found between groups for isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT), ejection time (ET), left mod‐MPI, EFT (p = 0.117; p = 0.093; p = 0.398; p = 0.882; p = 0.202, respectively). Umbilical artery Doppler pulsatility index (PI), mean uterine artery Doppler pulsatility index (PI), were higher in the EOPE group than in the control group (p = 0.006; and p = <0.001, respectively). The CPUR value for predicting EOPE was ≤1.3652 with 74. 4% sensitivity and 94.9% specificity. Positive correlations were found between CPUR, CPR, and some neonatal parameters.ConclusionCPUR, a new index combining fetal and uterine Doppler indices, may add contribution to predict adverse perinatal outcome and EOPE.

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Second Trimester Fetal and Maternal Epicardial Fat Thickness in Gestational Diabetic Pregnancies

Cited by 22 publications

References 25 publications

Increased fetal epicardial fat thickness: A novel ultrasound marker for altered fetal metabolism in diabetic pregnancies

Increased fetal epicardial fat thickness: A novel ultrasound marker for altered fetal metabolism in diabetic pregnancies

Depot and sex-specific implications for adipose tissue expandability and functional traits in adulthood of late prenatal and early postnatal malnutrition in a precocial sheep model

A new Doppler index, cerebro‐placental‐uterine ratio, and fetal cardiac parameters in early onset preeclampsia

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