“…3 Many potential causes of capsular contracture have been suggested, including biofilm, subclinical infection, soft-tissue trauma, silicone implant rupture, hematoma, seroma, and radiation. 2,8,9 These all increase inflammation and immune system activation, leading to increased scar formation. 5,6 The biofilm theory is supported by both laboratory and clinical evidence and is the most widely accepted in the surgical literature.…”