Secondary immunodeficiency as a consequence of chronic diseases

Chovancová, Zita

doi:10.36290/vnl.2019.024

Vnitř Lék

2019

DOI: 10.36290/vnl.2019.024

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Secondary immunodeficiency as a consequence of chronic diseases

Zita Chovancová¹

Abstract: Sekundární imunodeficience (SID) představuje stav získané poruchy funkce imunitního systému, který nevzniká na dědičném podkladě, jako je to v případě primárních imunodeficiencí (PID). Tyto získané poruchy funkce imunitního systému se rozvíjejí v důsledku celkové změny organizmu působením vnějších i vnitřních vlivů, v důsledku základního onemocnění nebo jeho léčby. Představují značně heterogenní skupinu onemoc-nění s rozmanitou etiologií. Na rozdíl od PID se vyskytují poměrně často, a to zejména v dospělé popu… Show more

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Cited by 6 publications

References 45 publications

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Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T)

et al. 2023

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Background Immunocompromised patients with acute diverticulitis are at increased risk of morbidity and mortality. The aim of this study was to compare clinical presentations, types of treatment, and outcomes between immunocompromised and immunocompetent patients with acute diverticulitis. Methods We compared the data of patients with acute diverticulitis extracted from the Web-based International Registry of Emergency Surgery and Trauma (WIRES-T) from January 2018 to December 2021. First, two groups were identified: medical therapy (A) and surgical therapy (B). Each group was divided into three subgroups: nonimmunocompromised (grade 0), mildly to moderately (grade 1), and severely immunocompromised (grade 2). Results Data from 482 patients were analyzed—229 patients (47.5%) [M:F = 1:1; median age: 60 (24–95) years] in group A and 253 patients (52.5%) [M:F = 1:1; median age: 71 (26–94) years] in group B. There was a significant difference between the two groups in grade distribution: 69.9% versus 38.3% for grade 0, 26.6% versus 51% for grade 1, and 3.5% versus 10.7% for grade 2 (p < 0.00001). In group A, severe sepsis (p = 0.027) was more common in higher grades of immunodeficiency. Patients with grade 2 needed longer hospitalization (p = 0.005). In group B, a similar condition was found in terms of severe sepsis (p = 0.002), quick Sequential Organ Failure Assessment score > 2 (p = 0.0002), and Mannheim Peritonitis Index (p = 0.010). A Hartmann’s procedure is mainly performed in grades 1–2 (p < 0.0001). Major complications increased significantly after a Hartmann’s procedure (p = 0.047). Mortality was higher in the immunocompromised patients (p = 0.002). Conclusions Immunocompromised patients with acute diverticulitis present with a more severe clinical picture. When surgery is required, immunocompromised patients mainly undergo a Hartmann’s procedure. Postoperative morbidity and mortality are, however, higher in immunocompromised patients, who also require a longer hospital stay.

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Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T)

et al. 2023

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GFPT2 pan-cancer analysis and its prognostic and tumor microenvironment associations*

Zhang

Wang

Wei

et al. 2021

Oncology and Translational Medicine

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ObjectiveGlutamine fructose-6-phosphate transaminase 2 (GFPT2) is involved in a wide range of biological functions in human cancer. However, few studies have comprehensively analyzed the correlation between GFPT2 and different cancer prognoses and tumor microenvironments (TMEs).MethodsWe evaluated the expression level and prognostic value of GFPT2 using updated public databases and multiple comprehensive bioinformatics analysis methods and explored the relationship between GFPT2 expression and immune infiltration, immune neoantigens, tumor mutational burden (TMB), and microsatellite instability in pan-cancer.ResultsGFPT2 was highly expressed in five cancers. GFPT2 expression correlates with the prognosis of several cancers from The Cancer Genome Atlas (TCGA) and is significantly associated with stromal and immune scores in pan-cancer. High GFPT2 expression in BLCA, BRCA, and CHOL was positively correlated with the infiltration of immune cells, such as B-cells, CD4+ T, CD8+ T cells, dendritic cells, neutrophils, and macrophages.ConclusionHigh GFPT2 expression may modify the outcomes of patients with BLCA, BRCA, or CHOL cancers by increasing immune cell infiltration. These findings may provide insights for further investigation into GFPT2 as a potential target in pan-cancer.

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Immune-mediated conditions and cellular biomarkers for early diagnosis of oral diseases

Guan,

Polonowita,

Sun

et al. 2023

Nano TransMed

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Secondary immunodeficiency as a consequence of chronic diseases

Cited by 6 publications

References 45 publications

Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T)

Acute diverticulitis in immunocompromised patients: evidence from an international multicenter observational registry (Web-based International Register of Emergency Surgery and Trauma, Wires-T)

GFPT2 pan-cancer analysis and its prognostic and tumor microenvironment associations*

Immune-mediated conditions and cellular biomarkers for early diagnosis of oral diseases

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