Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates

Russo, Venera; Continella, Alberto; Drago, Carmelo; Gentile, Alessandra; Malfa, Stefano La; Leotta, Claudia Giovanna; Pulvirenti, Luana; Ruberto, Giuseppe; Pitari, Giovanni M.; Siracusa, Laura

doi:10.1371/journal.pone.0255831

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…Moreover, among anthocyanins, cyanidin 3- O- glucoside was detected in all the samples, whereas delphinidin 3- O -glucoside was found only in M13 ( Table 3 , Figure S4 ). These results were in agreement with previous reports of the specialized metabolite composition in pomegranate peels [ 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Resultssupporting

confidence: 94%

Comparative Chemical Analysis of Eight Punica granatum L. Peel Cultivars and Their Antioxidant and Anti-Inflammatory Activities

et al. 2022

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A comparative quali-quantitative study of the peel extracts of eight Punica granatum cultivars obtained from underexploited areas of South Italy was carried out in order to valorize them as health-promoting by-products. The results showed that all of the samples possessed 45 ellagitannins, consisting mainly of polyhydroxyphenoyls; 10 flavonoids, belonging to flavonol, flavone, and catechin classes; and 2 anthocyanins. The most representative compounds underwent quantification through a LC-MS/MS multiple reaction monitoring (MRM)-based method; their qualitative profile was almost superimposable, while variability in the quantitative phenolic content was observed. The antioxidant activity was investigated using cell-free and cell-based assays. The in vitro anti-inflammatory potential was also studied by monitoring three typical markers of inflammation (IL-1β, IL-6, and TNF-α). Moderate differences in both activities were observed between the cultivars. Results showed that all of the investigated peels have a potential use as healthy bioactive phytocomplexes due to the interesting antioxidant and anti-inflammatory activities; in particular from the bioinformatic approaches a series of compounds, including galloyl-, pedunculagin- and ellagic acid-based, were found to be highly correlated with bioactivity of the extracts. Finally, the bioactivities showed by a Campanian local cultivar, ‘Granato di Aiello del Sabato’, could promote its cultivation by local farmers and germplasm conservation.

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Section: Resultssupporting

confidence: 94%

Comparative Chemical Analysis of Eight Punica granatum L. Peel Cultivars and Their Antioxidant and Anti-Inflammatory Activities

et al. 2022

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“…Green pomegranate peel extract showed anticancer properties in human lung adenocarcinoma and human colorectal carcinoma cells in vitro . Immature peel is an abundant source of polyphenols, particularly gallotannins like granatin B. Granatin B has antiproliferative and apoptotic activities against tumoral cells (Russo et al, 2021 ). Since punicalagin and granatin B arrest cells in the S-phase, they seem to be a good therapeutic agent against colorectal cancer (Chen et al, 2022 ).…”

Section: Oxidative Stressmentioning

confidence: 99%

Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

Kazemabad

Toni

Tizro

et al. 2022

Front. Aging Neurosci.

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Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD] and Parkinson's disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it. Pomegranate (Punica granatum L.) is one of the polyphenol-rich fruits that is widely mentioned in medical folklore. Pomegranate is commonly used to treat common disorders such as diarrhea, abdominal pain, wound healing, bleeding, dysentery, acidosis, microbial infections, infectious and noninfectious respiratory diseases, and neurological disorders. In the current review article, we aimed to summarize the data on the pharmacotherapeutic potentials of pomegranate in ANDs.

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“…Pomegranate juice consumption was demonstrated to directly affect insulin levels in type 2 diabetic patients and could contribute to additional control of glucose levels [ 4 ]. Extensive studies were performed to evaluate the anticancer [ 5 , 6 , 7 , 8 , 9 , 10 ] and antimicrobial activity of pomegranate extracts [ 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Polyphenols and Valorization of Fibers from Istrian-Grown Pomegranate (Punica granatum L.)

Skrt

Albreht

Vovk

et al. 2022

Foods

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Pomegranate fruit is an ancient fruit that is used not only because of its deep-red color and tasty arils but also due to the health benefits of its extracts. Pomegranate is a valuable source of bioactive compounds, including colorful anthocyanins and other polyphenols. The main objective of the present study was to gain comprehensive knowledge of the phenolic composition and antioxidative activity of a new pomegranate cultivar, grown in Northwest Istria, a part of the North Adriatic coastal area. Various parts of the pomegranate fruit parts were extracted in 70% ethanol or water. Total phenolic content and antioxidative capacity were respectively determined with Folin–Ciocalteu reagent and ABTS radical. Phenolics were examined and analyzed with TLC, LC-MS, and HPLC. Pomegranate juice was prepared from red arils and after thermal treatment, the stability of anthocyanins was monitored for several months to understand the effect of storage. The highest total phenolics were determined in ethanol pomegranate peel extracts (30.5 ± 0.6 mg GAE/g DM), and water peel extracts exhibited the highest antioxidative activity (128 ± 2 µg TE/g DM). After five months of storage of thermally treated pomegranate juice, 50–60 percentage points increase in anthocyanin degradation was observed. Pomegranate peel was further tested as a sustainable inedible food source for papermaking. Due to the low content of cellulose and the high percentage of extractives, as well as a distinguished texture and appearance, the paper made from pomegranate peel is best suited for the production of specialty papers, making it particularly interesting for bioactives recovery, followed by material restructuring.

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Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates

Cited by 9 publications

References 33 publications

Comparative Chemical Analysis of Eight Punica granatum L. Peel Cultivars and Their Antioxidant and Anti-Inflammatory Activities

Comparative Chemical Analysis of Eight Punica granatum L. Peel Cultivars and Their Antioxidant and Anti-Inflammatory Activities

Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

Extraction of Polyphenols and Valorization of Fibers from Istrian-Grown Pomegranate (Punica granatum L.)

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