Secondary metabolites and transcriptomic analysis of novel pulcherrimin producer Metschnikowia persimmonesis KIOM G15050: A potent and safe food biocontrol agent

Rahmat, Endang; Yu, Jae Sik; Lee, Bum Soo; Lee, Jiyoung; Ban, Yeongjun; Yim, Nam-Hui; Park, Jeong Hwan; Kang, Chang Ho; Kim, Ki Hyun; Kang, Youngmin

doi:10.1016/j.heliyon.2024.e28464

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e28464

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Secondary metabolites and transcriptomic analysis of novel pulcherrimin producer Metschnikowia persimmonesis KIOM G15050: A potent and safe food biocontrol agent

Endang Rahmat,

Jae Sik Yu,

Bum Soo Lee

et al.

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2024

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Cited by 2 publications

References 70 publications

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Unforeseen current and future benefits of uncommon yeast: the Metschnikowia genus

Haniffadli,

Ban,

Rahmat

et al. 2024

Appl Microbiol Biotechnol

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Metschnikowia, the single-cell yeast form, is a genus of 85 species in the Saccharomycetales order that developed in both aquatic and terrestrial ecosystems after being found in 1899. This yeast is commonly used to control microbial populations in many biological and artificial conditions, such as fermentation. However, current study of Metschnikowia is limited to biological control features rather than researching on lucrative sectors such as beverage production, bioconversion manufacturing, cosmetics, and the pharmaceutical industry. This review summarizes numerous possible applications of Metschnikowia in human life, including potential secondary metabolites in industrial fields such as cosmetics and pharmaceuticals. Furthermore, Metschnikowia-yeast interaction is mentioned as a potential area for further exploration in terms of co-cultured microbes as biocontrol. Since Metschnikowia yeast arose in a variety of ecosystems, more discussion will be held regarding the interactions between Metschnikowia and their surroundings, particularly in fruits. Finally, the current regulatory challenges of Metschnikowia-based products are examined, and future research opportunities on Metschnikowia utilization are presented. Key points • Utilization of Metschnikowia genus in various human aspects. • Promising secondary metabolites produced by Metschnikowia. • Challenge and opportunity on developing Metschnikowia-based products. Graphical Abstract

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Unforeseen current and future benefits of uncommon yeast: the Metschnikowia genus

Haniffadli,

Ban,

Rahmat

et al. 2024

Appl Microbiol Biotechnol

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Photoprotective Effects of Yeast Pulcherrimin

Kregiel,

Krajewska,

Kowalska-Baron

et al. 2024

Molecules

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Sunscreen products can protect the skin against the harmful effects of UV radiation, including reddening, aging, and cancer. The aim of this research was to evaluate the photoprotective effects of yeast pulcherrimin, an iron-chelating dipeptide. We first investigated the cytotoxicity of pulcherrimin produced by Metschnikowia pulcherrima yeast on the human keratinocyte HaCaT cell line, using the PrestoBlue assay. We assessed the ability of pulcherrimin to induce DNA repair after the exposure of HaCaT cells to oxidative stress. We also evaluated its protective activity against UVC radiation. The sun protective factor (SPF) was calculated using the Mansur equation. The UVA/UVB ratio values for pure pulcherrimin were evaluated using the Boots Star Rating system. The critical wavelength was determined by calculating the integrated optical density curve area. Based on the results, pulcherrimin shows strong cytoprotective effects through antioxidant and photoprotective activities on the HaCaT cell line. The calculated SPFs were 20 and 15 at pH = 7 and pH = 10, respectively. The critical wavelength above 370 nm and the UVA/UVB ratio R > 1 suggest that yeast pulcherrimin—a cyclic dipeptide containing iron—may be considered a promising photoprotective agent.

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Secondary metabolites and transcriptomic analysis of novel pulcherrimin producer Metschnikowia persimmonesis KIOM G15050: A potent and safe food biocontrol agent

Cited by 2 publications

References 70 publications

Unforeseen current and future benefits of uncommon yeast: the Metschnikowia genus

Unforeseen current and future benefits of uncommon yeast: the Metschnikowia genus

Photoprotective Effects of Yeast Pulcherrimin

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