Secondary Metabolites Produced by Solid Fermentation of the Marine-Derived FungusPenicillium communeQSD-17

Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

“…V. harveyi, Gaeumannomyces graminis and V. parahaemolyticus (Liu Y. et al, 2015). Six novel azaphilone derivatives ( 222 – 227 ) as major secondary metabolites were obtained from rotary PDB medium of one marine-derived strain P. commune QSD-17 (Gao et al, 2011), whereas other new compounds isophomenone ( 228 ) and 3-deacetylcitreohybridonol ( 229 ) were detected in its static rice medium (Gao et al, 2012).…”

Anti-neuroinflammatory effects of citreohybridonol involving TLR4-MyD88-mediated inhibition of NF-кB and MAPK signaling pathways in lipopolysaccharide-stimulated BV2 cells

“…SF5699, exhibiting anti-neuroinflammatory activity. Although citreohybridonol has been previously isolated (Kosemura et al, 1994;Gao et al, 2012;Kosemura, 2003), its biological effect has not been known. This study describes isolation, structure elucidation, and anti-neuroinflammatory effect of citreohybridonol.…”

Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis

“…Andrastone A ( 1 ) and 16-epi-citreohybriddione A ( 2 ) are two meroterpenoids biosynthesized from a sesquiterpene and a tetraketide. In fact, compounds possessing the same scaffold are rarely found in nature, including citreohybridones A and B (Kosemura et al, 1991b), Andrastins A–D (Shiomi et al, 1996; Uchida et al, 1996), atlantinones A and B (Wang et al, 2010), citreohybriddiones A–C (Kosemura, 2003), citreohybridones A–G and J–L (Kosemura, 2002), citreohybridonol (Oezkaya et al, 2018), 3-deacetylcitreohybridonol (Gao et al, 2012), 15-deacetylated citreohybridone E (Cheng et al, 2019), isocitreohybridones A–C and H–J (Kosemura, 2002, 2003), and isopenicins A–C (Tang et al, 2019). Among them, 18 possess a lactone moiety at the C-23 position.…”