Secondary organic aerosol formation from atmospheric reactions of anisole and associated health effects

Li, Chunlin; Misovich, Maria V.; Pardo, Michal; Fang, Zheng; Laskin, Alexander; Chen, Jianmin; Rudich, Yinon

doi:10.1016/j.chemosphere.2022.136421

Cited by 17 publications

(20 citation statements)

References 78 publications

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“…Although quinones can contribute a large amount of ROS, cytotoxicity caused by aromatic compounds derived SOA is still not well explained [15] . Among the gaseous degradation products of the benzene series, small carbonyl molecules, such as glyoxal and methylglyoxal account for a large proportion [136] .…”

Section: Anthropogenic Soamentioning

confidence: 99%

“…For example, naphthalene SOA has a stronger oxidation potential and causes more severe cell damage in comparison with αpinene SOA [25] . A study on the transcriptome showed that exposure to naphthalene SOA triggered Nrf2-mediated oxidative stress responses, and other pathways, such as redox signaling transduction, inflammatory signaling [15] , and matrix metalloproteinases also had a strong response. Compared with α-pinene SOA, these pathways had stronger effects after exposure to naphthalene SOA, which was also accompanied by various cellular activation of the mechanism [128] .…”

Section: Reviewmentioning

confidence: 99%

“…However, public concern about the atmospheric environment was triggered by numerous cases of secondary pollutants outbreaks, such as Los Angeles photochemical smog, etc., and the formation of more toxic secondary pollutants, such as ozone, peroxyacetyl nitrate(PAN), and secondary particulate matter [12] . The new WHO(World Health Organization) air quality guidelines also highlight the health risk of secondary pollutants, such as ozone, and dramatically raise the standard of NO2, which is vital in secondary pollutants formation [13] , but the health risks of secondary pollutants are highly uncertain [14,15] . First of all, this is mainly due to the fact that the formation of secondary pollutants involves a variety of physical and chemical processes and thousands of compounds at the same time.…”

Section: Introductionmentioning

confidence: 99%

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Toxicological Effects of Secondary Air Pollutants

Xiang

Wang

et al. 2023

Chem. Res. Chin. Univ.

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S econdary air pollutants, originating from gaseous pollutants and primary particulate matter emitted by natural sources and human activities, undergo complex atmospheric chemical reactions and multiphase processes. Secondary gaseous pollutants represented by ozone and secondary particulate matter, including sulfates, nitrates, ammonium salts, and secondary organic aerosols, are formed in the atmosphere, affecting air quality and human health. This paper summarizes the formation pathways and mechanisms of important atmospheric secondary pollutants. Meanwhile, different secondary pollutants’ toxicological effects and corresponding health risks are evaluated. Studies have shown that secondary pollutants are generally more toxic than primary ones. However, due to their diverse source and complex generation mechanism, the study of the toxicological effects of secondary pollutants is still in its early stages. Therefore, this paper first introduces the formation mechanism of secondary gaseous pollutants and focuses mainly on ozone’s toxicological effects. In terms of particulate matter, secondary inorganic and organic particulate matters are summarized separately, then the contribution and toxicological effects of secondary components formed from primary carbonaceous aerosols are discussed. Finally, secondary pollutants generated in the indoor environment are briefly introduced. Overall, a comprehensive review of secondary air pollutants may shed light on the future toxicological and health effects research of secondary air pollutants.

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Section: Anthropogenic Soamentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicological Effects of Secondary Air Pollutants

Xiang

Wang

et al. 2023

Chem. Res. Chin. Univ.

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“…9,39 Despite the hypothesis that the aging of organic aerosols by NO 3 ˙ may play a crucial role in their toxicity, limited studies have explored this topic. 25,40…”

Section: Introductionmentioning

confidence: 99%

“…The underlying mechanisms highly depend on the compositions and aging of SOA. 14,[24][25][26][27][28][29] However, there is still ongoing discussion about the changes in SOA toxicity following the photooxidation. 30 Furthermore, while the importance of OP and oxidative stress has been emphasized, the AOC of SOA has been largely overlooked, potentially leading to a biased assessment of the overall adverse health effects of organic aerosols thus limiting the understanding of the associated mechanisms.…”

Section: Introductionmentioning

confidence: 99%