Secondary Osteosarcoma After Bone Marrow Transplant: An Aggressive Disease

Pierobon, Marta; Mercolini, Federico; Affinita, Maria Carmen; Tombolan, Lucia; Battisti, Laura; Bisogno, Gianni

doi:10.1089/jayao.2020.0054

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…From the perspective of comprehensive treatment, SO is less sensitive to conventional chemotherapy than primary osteosarcoma 34 , and surgery becomes a radical treatment. In addition, some researchers found that biophysical therapy, immunotherapy and Regorafenib may be adjunctive therapies affecting patients’ surgical survival 10 . Therefore, we believe that assisted surgical treatment can also improve patients’ understanding of the treatment of SO, thus improving patients’ surgical compliance, whose effectiveness clearly needs more investigation.…”

Section: Discussionmentioning

confidence: 99%

Survival analysis and prognostic model establishment of secondary osteosarcoma: a SEER-based study

Wang,

Fu,

Zhu

et al. 2024

Annals of Medicine &Amp; Surgery

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Background: Surgical excision is considered as one of the effective treatments for secondary osteosarcoma (SO). It remain unclear that whether the survival of patients with SO could be associated with their surgical willingness. Materials and Methods: The statistics of the patients diagnosed with SO between 1975 and 2008 were gathered from the surveillance epidemiology and end results (SEER) database. The patients were divided into three subgroups according to their surgical compliance. We used the multivariable Logistic regression analysis and cox regression method to reveal the influence of surgical compliance on prognosis and the risk factors of surgical compliance as well. Additionally, we formulated a nomogram model to predict the overall survival (OS) of patients. The concordance index (C-index) was used to evaluate the accuracy and practicability of the above prediction model. Results: 63(9.2%) of the 688 patients with SO who were recommended for surgical treatment refused to undergo surgery. Lower surgical compliance can be ascribed to earlier time of diagnosis and refused chemotherapy. The lower OS ([Hazard ratio (HR)] 1.733, [Confidential interval (CI)] 1.205-2.494, P-value (P)=0.003) of not surgical compliant patients was verified by the multivariate cox regression method, compared with surgical compliant patients. In addition, the discernibility of the nomogram model was proven to be relatively high (C-index=0.748), by which we can calibrate 3 year- and 5 year-OS prediction plots to obtain good concordance to actual situation. Conclusion: The surgical compliance was proved to be an independent prognostic factor to survival of patients with SO.

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Section: Discussionmentioning

confidence: 99%