Secondhand smoke affects reproductive functions by altering the mouse testis transcriptome, and leads to select intron retention in Pde1a

Tommasi, Stella; Kitapci, Tevfik Hamdi; Blumenfeld, Hannah; Besaratinia, Ahmad

doi:10.1016/j.envint.2022.107086

Cited by 3 publications

(1 citation statement)

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“…Among the downregulated pathways they found several metabolic signals, such as FoxO and Wnt, but more interestingly the cGMP-PKG signaling pathway [159]. Another gene that was found to be significantly associated with testicular cancer was PDE1A [160] and in vivo exposure of mice to secondhand smoke produced a unique 'frameshift' variant within the murine PDE1A suggesting an involvement of this PDE in non-familial testicular cancer [161].…”

Section: Phosphodiesterases In Testicular Cancermentioning

confidence: 99%

Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers

Campolo

Assenza

Venneri

et al. 2023

IJMS

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Phosphodiesterases are key regulators that fine tune the intracellular levels of cyclic nucleotides, given their ability to hydrolyze cAMP and cGMP. They are critical regulators of cAMP/cGMP-mediated signaling pathways, modulating their downstream biological effects such as gene expression, cell proliferation, cell-cycle regulation but also inflammation and metabolic function. Recently, mutations in PDE genes have been identified and linked to human genetic diseases and PDEs have been demonstrated to play a potential role in predisposition to several tumors, especially in cAMP-sensitive tissues. This review summarizes the current knowledge and most relevant findings regarding the expression and regulation of PDE families in the testis focusing on PDEs role in testicular cancer development.

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Section: Phosphodiesterases In Testicular Cancermentioning

confidence: 99%