Secretory immune system in human embryonic and fetal development: Joining chain and immunoglobulin transport (Review)

Ben‐Hur, Herzl; Gurevich, Pavel; Elhayany, Asher; Moldavsky, Moisey; Shvidel, Lev; Shezen, Eli; Shumlin, Nina; Zusman, Itshak

doi:10.3892/ijmm.14.1.35

Cited by 4 publications

(4 citation statements)

References 48 publications

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“…Complete absence of pIgR in humans has not been identified (184), although it is clear that the receptor is not essential neither for development nor for the health of mice kept in a conventional laboratory facility. Although IgA secretion appears already operative in early stages of the embryogenesis (185), from these studies in pIgRdeleted mice one can conclude that the essential role of retromer during embryogenesis is unrelated to pIgR-pIgA trafficking.…”

Section: The Polymeric Immunoglobulin Receptormentioning

confidence: 86%

Retromer and sorting nexins in development

Vergés¹

2007

Front Biosci

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Trafficking and signaling processes involve common molecular components. The machinery that controls intracellular trafficking is vital in ensuring that signaling mechanisms take place correctly. An illustrative example of this relationship is the sustained signaling of endocytosed membrane receptors, such as receptor Tyr kinases and G-protein coupled receptors, after ligand-induced activation. An intriguing role in controlling the fate of these and other receptors at the endosome has been attributed to members of the sorting nexin protein family. The best characterized sorting nexins are subunits of a multimeric complex, termed retromer. It was first found in yeast that retromer mediates endosome-to-Golgi retrieval of receptors after they have delivered soluble hydrolase precursors into the vacuole, the organelle equivalent to the mammalian lysosome. Work in cultured mammalian cells later demonstrated that retromer performs an analogous function in higher eukaryotes. Data from genetically modified mice, and from a simpler organism such as the nematode Caenorhabtidis elegans, has revealed that retromer performs an essential role during embryogenesis. This review will discuss implications of recent work on this subject.

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Section: The Polymeric Immunoglobulin Receptormentioning

confidence: 86%

Retromer and sorting nexins in development

Vergés¹

2007

Front Biosci

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“…The polymeric immunoglobulin receptor (pIgR) and 52 kDa repressor of the inhibitor (P52rIPK) were involved in signal transduction of missing proteins. pIgR facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M. pIgR is widely present in all ectoderm- and endoderm-derived structures and was present in 4-week-old embryos [ 63 ]. P52rIPK is an upstream regulator of interferon-induced serine/threonine protein kinase R (PKR).…”

Section: Discussionmentioning

confidence: 99%

Missing and overexpressing proteins in domestic cat oocytes following vitrification and in vitro maturation as revealed by proteomic analysis

et al. 2018

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BackgroundThe domestic cat serves as an animal model for assisted reproductive studies of endangered felid species. To date, there are no data on the protein alterations following cryopreservation of oocytes in felid family.MethodsImmature (germinal vesicle) domestic cat oocytes were vitrified in the vitrification solution containing 35% ethylene glycol, 20% DMSO and 0.5 mM sucrose. The vitrified-warmed oocytes were matured (metaphase II) in vitro and subjected to proteomic analysis using 1DE SDS-PAGE prefractionation combined with LC–MS/MS.ResultsA total of 1712 proteins were identified in in vitro matured oocytes. Of the 1712 proteins, 1454 proteins were found in both groups, whereas, 258 proteins were differentially expressed between control and vitrified-warmed groups. In vitrified-warmed oocytes, the missing proteins were membrane and nuclear proteins; whereas, apoptosis and DNA repair proteins were overrepresented.ConclusionsThe identified missing and overexpressed proteins in vitrified-warmed oocytes represent potential markers of cryoinjuries and the developmental pathways of oocytes. The findings of differential expressed proteins may contribute to effective ways of proteome analysis of oocyte/embryo quality in order to assess safety of cryopreservation in felid species.

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“…Furthermore, we were able to demonstrate that there is also an association of pIgR with CAD and heart failure. Due to the fact that pIgR/SC is not expressed in heart cells 15 , our findings point towards inflammatory pathways with respect to cardiovascular disease risk. A first hint in this direction was shown in a study where pIgR is associated with coronary atherosclerosis in coronary vessels of individuals chronically exposed to increased ambient concentrations of traffic air pollution 16 .…”

Section: Discussionmentioning

confidence: 84%

Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome

Siwy

Metzger

et al. 2020

Sci Rep

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the polymeric immunoglobulin receptor (pigR) transports immunoglobulins from the basolateral to the apical surface of epithelial cells. PIgR was recently shown to be associated with kidney dysfunction. the immune defense is initiated at the apical surface of epithelial cells where the n-terminal domain of pIgR, termed secretory component (SC), is proteolytically cleaved and released either unbound (free SC) or bound to immunoglobulins. The aim of our study was to evaluate the association of pIgR peptides with the cardio-renal syndrome in a large cohort and to obtain information on how the Sc is released. We investigated urinary peptides of 2964 individuals available in the Human Urine Proteome Database generated using capillary electrophoresis coupled to mass spectrometry. The mean amplitude of 23 different pIgR peptides correlated negatively with the estimated glomerular filtration rate (eGFR, rho = −0.309, p < 0.0001). Furthermore, pIgR peptides were significantly increased in cardiovascular disease (coronary artery disease and heart failure) after adjustment for eGFR. We further predicted potential proteases involved in urinary peptide generation using the Proteasix algorithm. Peptide cleavage site analysis suggested that several, and not one, proteases are involved in the generation of the SC. In this large cohort, we could demonstrate that pIgR is associated with the cardio-renal syndrome and provided a more detailed insight on how pIgR can be potentially cleaved to release the SC.

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Secretory immune system in human embryonic and fetal development: Joining chain and immunoglobulin transport (Review)

Cited by 4 publications

References 48 publications

Retromer and sorting nexins in development

Retromer and sorting nexins in development

Missing and overexpressing proteins in domestic cat oocytes following vitrification and in vitro maturation as revealed by proteomic analysis

Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome

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