Security and efficiency of a closed-system, turbulent-flow circuit for hyperthermic intraperitoneal chemotherapy after cytoreductive ovarian surgery: perioperative outputs

Pascual-Ramírez, Javier; García, Susana Sánchez; Herran, F. Gonzalez Ruiz de la; Campos, Pedro Villarejo; Cano, Carlos López de la Manzanara; Palazuelo, J. Haya; Padilla, David; Fernández, Jesús Martín

doi:10.1007/s00404-014-3153-4

Cited by 16 publications

(9 citation statements)

References 50 publications

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“…These findings are in accordance with those of Pascual-Ramírez et al who did not detect any difference in haemodynamic parameters during CRS and HIPEC when describing the closed technique in ovarian cancer patients, as it was also known from the study of Desgranges et al [2, 3]. Similarly, in the Pascual-Ramírez series there was not a rise in body temperature or a disturbance in renal function, as in our study and the one conducted by Schmidt et al [3, 4].…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, in the Pascual-Ramírez series there was not a rise in body temperature or a disturbance in renal function, as in our study and the one conducted by Schmidt et al [3, 4]. …”

Section: Discussionsupporting

confidence: 88%

“…In the Pascual-Ramírez study, an increase in heart rate was reported, attributed to increased vasodilatation and relative volume deficit due to heat increase [3]. However, this finding is not present in our study, possibly due to the decreased fluid turnover that occurs in the closed method as opposed to the open one and the positive fluid balance perioperatively.…”

Section: Discussioncontrasting

confidence: 77%

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Peritoneal Carcinomatosis: Intraoperative Parameters in Open (Coliseum) versus Closed Abdomen Hipec

Halkia

Tsochrinis

Vassiliadou

et al. 2015

International Journal of Surgical Oncology

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Background. Peritoneal carcinomatosis (PC) is associated with a poor prognosis. Cytoreductive surgery (CRS) and HIPEC play an important role in well-selected patients with PC. The aim of the study is to present the differences in the intraoperative parameters in patients who received HIPEC in two different manners, open versus closed abdomen. Patients and Methods. The population includes 105 patients with peritoneal carcinomatosis from colorectal, gastric, and ovarian cancer, sarcoma, mesothelioma, and pseudomyxoma peritonei. Group A (n = 60) received HIPEC using the open technique and Group B (n = 45) received HIPEC with the closed technique. The main end points were morbidity, mortality, and overall hospital stay. Results. There were two postoperative deaths (3.3%) in the open group versus no deaths in the closed group. Twenty-two patients in the open group (55%) had grade III-IV complications versus 18 patients in the closed group (40%). There are more stable intraoperative conditions in the closed abdomen HIPEC in CVP, pulse rate, and systolic pressure parameters. Conclusions. Both methods are equal in the HIPEC procedures. Perhaps the closed method is the method of choice for frail patients due to more stable hemodynamic parameters.

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Section: Discussionsupporting

confidence: 92%

“…Similarly, in the Pascual-Ramírez series there was not a rise in body temperature or a disturbance in renal function, as in our study and the one conducted by Schmidt et al [3, 4]. …”

Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 77%

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Peritoneal Carcinomatosis: Intraoperative Parameters in Open (Coliseum) versus Closed Abdomen Hipec

Halkia

Tsochrinis

Vassiliadou

et al. 2015

International Journal of Surgical Oncology

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“…Pre-operative symptoms were defined as pain with opioid control, ascites with fullness discomfort, and obstruction with constipation and vomiting. Postoperative complications were classified using a previously validated system, the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 4.0 [22]. Mortality was defined as any death occurring during 30 days after surgery or during hospitalisation.…”

Section: Follow-up Strategymentioning

confidence: 99%

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal malignancy: preliminary results of a multi-disciplinary teamwork model in Asia

Wang

Chen

et al. 2017

International Journal of Hyperthermia

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“…Another trial is being conducted by the European Network of Excellence on GC. In this trial, patients with high risk GC will receive three cycles of neoadjuvant systemic chemotherapy followed by a D2 gastrectomy and then randomized to receive HIPEC or no HIPEC (65).…”

Section: Crs + Hipec Clinical Experience: Promising Resultsmentioning

confidence: 99%

A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical management of advanced gastric cancer: an effective multimodality approach with scope for improvement

Beeharry

Yao

et al. 2016

Transl. Gastroenterol. Hepatol.

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Peritoneal carcinomatosis (PC) is manifested in up to 40% of gastric cancer (GC) patients, after which their 5-year survival drops to less than 5%. The currently most acceptable treatment option for advanced GC (AGC) is systemic chemo and radio therapies with however generally very unsatisfying results and this led to a resurgence of interest in regional therapies like cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Small trials have indicated an association with prolonged survival when applying this technique to AGC manifesting with PC. High procedure-related morbidity and mortality associated with the CRS-HIPEC approach have however brought by a polemic on the merits of the latter: with the advent of regulatory approval of more effective as well as novel, more personalized treatment options in AGC, along with advances in tailoring investigational agents specifically for peritoneal delivery, there clearly is a need to outline the appropriate role of CRS-HIPEC in this disease.In a clear objective to improve the therapeutic efficiency of HIPEC, there have been immense developments in the technical aspects of this technology including the use of nanotechnology in more precise drug delivery systems (DDS) or choice of more efficient drugs such as gene-target technology, laparoscopy and so on. Henceforth, in this review, we will be highlighting the past and current status of the CRS + HIPEC procedure, shedding light on the pros and cons in order to boost up the efficiency of this multimodality approach.

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Security and efficiency of a closed-system, turbulent-flow circuit for hyperthermic intraperitoneal chemotherapy after cytoreductive ovarian surgery: perioperative outputs

Abstract: A turbulent-flow, closed-circuit use for hyperthermic peritoneal intraoperative chemotherapy resulted in no hyperdynamic response or coagulopathy, had good tolerance and promoted early physiologic recovery.

Cited by 16 publications

References 50 publications

Peritoneal Carcinomatosis: Intraoperative Parameters in Open (Coliseum) versus Closed Abdomen Hipec

Peritoneal Carcinomatosis: Intraoperative Parameters in Open (Coliseum) versus Closed Abdomen Hipec

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal malignancy: preliminary results of a multi-disciplinary teamwork model in Asia

A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical management of advanced gastric cancer: an effective multimodality approach with scope for improvement

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