In this paper, a high security chaotic encryption scheme for orthogonal frequency division multiplexing (OFDM) transmission system is proposed by using power division multiplexing (PDM) technology and four-dimensional region joint encryption. The scheme uses PDM to realize simultaneous transmission of multiple user information, which can achieve a good compromise among system capacity, spectral efficiency and user fairness. In addition, bit cycle encryption, constellation rotation disturbance (CRD) and region joint constellation disturbance (RJCD) are used to realize four-dimensional region joint encryption, effectively improving the physical layer security. The masking factor is generated by the mapping of two-level chaotic systems, which can enhance the nonlinear dynamics and improve the sensitivity of encrypted system. A 11.76 Gb/s OFDM signal transmission over 25 km standard single-mode fiber (SSMF) is experimentally demonstrated. At the forward-error correction (FEC) bit error rate (BER) limit -3.8×10−3, the proposed receiver optical power based on quadrature phase shift keying (QPSK) without encryption, QPSK with encryption, variant-8quadrature amplitude modulation (V-8QAM) without encryption and V-8QAM with encryption are about -13.5dBm, -13.6dBm, -12.2dBm, and -12.1dBm. The key space is up to 10128. The results show that this scheme not only improves the security of the system and the ability to resist attackers, but also improves the system capacity and has the potential to serve more users. It has a good application prospect in the future optical network.