This paper focused on the prevention of library collection security breaches in Ohangwena and Oshana Regional Libraries. A qualitative research design was employed and a case study strategy was adopted for the study. The population consisted of 12 staff members from Ohangwena and Oshana Regional Library who were selected through purposive sampling. Data was collected through telephone interviews and presented qualitatively in form of descriptive narratives. The study revealed that most of staff members working in these libraries held qualifications which were not related to librarianship. The findings revealed that over borrowing of books, theft and vandalism of library collection were very common in these libraries and occurred on a weekly basis. Further findings showed that measures such as the use of 3M library security system, CCTV, security personnel and lockers to keep users’ bags were in place to address security issues. Penalties such as replacement of lost or damaged items, suspension of offenders, fines for over borrowing were imposed upon users in these libraries. A major recommendation was that libraries should formulate national policies and guidelines to guide library staff on how to handle security breaches. Additionally, the government should recognize theft and vandalism of library materials as a crime because currently, users tend to commit these ill-acts since no criminal case is opened against them.