Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA-ergic systems: Involvement of 5-HT1A receptor agonistic activity

Oh, Dool-Ri; Kim, Yujin; Jo, Ara; Choi, Eun Jin; Oh, Kangho; Kim, Jae-Yong; Kang, Huwon; Kim, Young Ran; Choi, Chul Yung

doi:10.1016/j.biopha.2018.10.003

Cited by 25 publications

(9 citation statements)

References 49 publications

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“…The open-field test (OFT) is commonly used to assess the locomotor activities and sedative effects of various compounds. 16 The effect of GAS and HBA on zebrafish larvae motion was expressed as the change in mean velocity within each 10 min interval versus the baseline velocity. As shown in Figure 4, GAS and HBA treatment resulted in a decrease in the velocity of zebrafish larvae when compared with the control treatment.…”

Section: Effect Of Gas and Hba On Locomotor Activitymentioning

confidence: 99%

Characterization by HPLC of p-Hydroxybenzyl Alcohol Biotransformation to Gastrodin In Vivo

Cheng

Deng²

2021

Natural Product Communications

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Gastrodin (GAS) and its aglycone, p-hydroxybenzyl alcohol (HBA), are both bioactive compounds extracted from Gastrodia elata Blume (GEB). In the current Chinese pharmacopoeia, they are regarded as quality control markers for GEB. In this study, we developed a high-performance liquid chromatography method coupled with a diode array detector to quantify GAS and HBA concentrations in plasma following oral ingestion by rats. For the first time, GAS was detected in vivo after HBA administration. GAS and HBA both had similar pharmacological effects, but the influence of the glucose moiety resulted in different pharmacokinetic characteristics. In this study, the effects of GAS and HBA at different administration durations were investigated in zebrafish larvae. These compounds were found to induce a sedative effect but had different onset times. In conclusion, a biotransformation of HBA to GAS could be observed in the rats. This may be a new insight into the pharmacokinetic characteristics of these bioactive compounds and also relates to the different ways in which they take effect.

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Section: Effect Of Gas and Hba On Locomotor Activitymentioning

confidence: 99%

Characterization by HPLC of p-Hydroxybenzyl Alcohol Biotransformation to Gastrodin In Vivo

Cheng

Deng²

2021

Natural Product Communications

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“…Previous studies have demonstrated that VB exerted various pharmacological effects, including antifatigue ( 30 ), antimicrobial ( 31 ), antidiabetic ( 32 , 33 ), antioxidant ( 34 ), retinal protection ( 35 ), antiproliferative, and antiinflammatory effects ( 36 , 37 ). We have previously reported that the fruit of VB exhibited antidepressant properties, protective effects on oxidative stress-induced apoptosis, sedative, and hypnotic effects ( 38 – 40 ). In addition, we have also reported the antidepressant-like effects of the combination of fruit extracts of SH and VB (SHVB), especially in models of congenital rubella syndrome and related depression disorders ( 41 ).…”

Section: Popular Scientific Summarymentioning

confidence: 99%

Antipostmenopausal effects of Stauntonia hexaphylla and Vaccinium bracteatum fruit combination in estrogen-deficient rats

Lee

Shin²,

et al. 2020

Food & Nutrition Research

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Background Climacterium is a series of physical and mental symptoms occurring in women and men due to decreased levels of sex hormones. Women lose the ability to become pregnant due to decreased ovarian estrogen production; the initial symptom being hot flushes. In addition, urogenital atrophy, sexual dysfunction, mood changes, and osteoporosis occur. Extracts of Stauntonia hexaphylla (SH) and Vaccinium bracteatum (VB) fruits, with a wide range of biological activities, are widely used in traditional herbal medicine. Objective The purpose of this study was to investigate the mitigation of menopausal symptoms, such as hot flushes and postmenopausal osteoporosis after combinatorial treatment with SH and VB (SHVB) of ovariectomized (OVX) rats. Design We measured the bone regenerative effect of SHVB on receptor activator of nuclear factor-κB (NF-κB) ligand-induced osteoclast differentiation in vitro and on ovariectomy-induced osteoporosis in vivo . We investigated the effect of SHVB in a rat model of menopausal hot flushes, in which the tail skin temperature increases following ovariectomy-induced rapid decline in estrogen levels. Results SHVB inhibited osteoclast formation and tartrate-resistant acid phosphatase activity in primary mouse bone marrow-derived cells. In an estrogen deficiency-induced rat model, measurement of serum bone turnover factors showed that treatment with SHVB lowered the increased bone turnover. Additionally, SHVB decreased OVX-induced bone loss of the total femur. SHVB inhibited osteoclast differentiation, prevented bone mass reduction, and improved trabecular bone structure and biochemical markers in OVX-induced osteoporosis. In addition, administration of SHVB significantly ameliorated the changes in skin temperature in OVX rats. Conclusion SHVB improved the symptoms of menopause. These results provide the foundation for developing SHVB as a natural substance to replace hormones in the future.

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“…Insomnia is often seen and treated as a symptom rather than a disease. Antidepressants and sedative and hypnotic drugs are used for insomnia, especially benzodiazepines, such as diazepam, which are sedative-hypnotic drugs used for the modulation of γ-aminobutyric acid (GABA) receptors [2]. The side effects of such hypnotic drugs make people uneasy about their use.…”

Section: Introductionmentioning

confidence: 99%

Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey

et al. 2020

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Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.

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Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA-ergic systems: Involvement of 5-HT1A receptor agonistic activity

Cited by 25 publications

References 49 publications

Characterization by HPLC of p-Hydroxybenzyl Alcohol Biotransformation to Gastrodin In Vivo

Characterization by HPLC of p-Hydroxybenzyl Alcohol Biotransformation to Gastrodin In Vivo

Antipostmenopausal effects of Stauntonia hexaphylla and Vaccinium bracteatum fruit combination in estrogen-deficient rats

Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey

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