Sedentary Behavior and Cancer: A Systematic Review of the Literature and Proposed Biological Mechanisms

Lynch, Brigid M.

doi:10.1158/1055-9965.epi-10-0815

Cited by 319 publications

(320 citation statements)

References 147 publications

(239 reference statements)

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“…Little is known about objectively assessed sedentary time among breast cancer survivors, other than minimal descriptive data showing survivors spent an average of 66% (i.e., $9 hours) of their day in sedentary pursuits (4). Nonetheless, self-reported sedentary time has been associated with markers of adiposity, comorbidities, and psychosocial health outcomes among colorectal cancer survivors and breast cancer survivors (6,8). Objective assessments are needed to gain a better understanding of sedentary behaviors and related predictors and outcomes.…”

Section: Introductionmentioning

confidence: 99%

Prospective Examination of Objectively Assessed Physical Activity and Sedentary Time after Breast Cancer Treatment: Sitting on the Crest of the Teachable Moment

Sabiston

Brunet

Vallance

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: This study prospectively examined patterns of objectively assessed sedentary time and moderate-to-vigorous physical activity (MVPA) during a 1-year period following completion of primary treatment among breast cancer survivors. The potential moderating effect of weight status on sedentary and MVPA time was also examined.Methods: Breast cancer survivors [n ¼ 177; M(SD) age ¼ 54.9 (11.1) years, 85% White/Caucasian; 82% stage I or II cancer; M(SD) time since treatment ¼ 3.5 (2.4) months] who were recruited into a convenience sample had weight, height, and waist circumference measured and wore Actigraph GT3X accelerometers for 1 week every 3 months for 1 year. Data were analyzed using repeated measures ANOVA.Results: Survivors spent nearly 78% of their day sedentary across all time points compared with less than 2% of their day engaged in MVPA. Sedentary time remained fairly stable over 12 months, whereas MVPA levels significantly decreased. Survivors with an overweight body mass index and unhealthy waist-to-height ratio engaged in significantly less MVPA than healthy weight survivors, with significant waist-to-height ratio moderator effects for both sedentary and MVPA.Conclusions: Sedentary time remains high in the first year following treatment for breast cancer, and MVPA decreases. These trends are more pronounced for survivors who are overweight, with stronger effects noted when waist-to-height ratio was examined compared with body mass index.Impact: These findings suggest that breast cancer survivors may be doing very little to improve their lifestyle behaviors following a cancer diagnosis and treatments. Cancer Epidemiol Biomarkers Prev; 23(7); 1324-30. Ó2014 AACR.

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Section: Introductionmentioning

confidence: 99%

Prospective Examination of Objectively Assessed Physical Activity and Sedentary Time after Breast Cancer Treatment: Sitting on the Crest of the Teachable Moment

Sabiston

Brunet

Vallance

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Furthermore, while prolonged periods of sitting have been associated, independent of physical activity, with premature mortality, cardiovascular disease, type II diabetes mellitus, as well as some cancers (4), the relation between sitting time and postmenopausal breast cancer risk is not well understood (5,6).…”

Section: Introductionmentioning

confidence: 99%

Recreational Physical Activity and Leisure-Time Sitting in Relation to Postmenopausal Breast Cancer Risk

Hildebrand

Gapstur

Campbell

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Epidemiologic evidence supports an inverse association between physical activity and postmenopausal breast cancer. Whether associations exist for moderate activities, such as walking, and whether associations differ by estrogen receptor (ER) status, body mass index (BMI, kg/m 2 ), adult weight gain, or use of postmenopausal hormones (PMH) is unclear. The relation between time spent sitting and breast cancer also is unclear. Among 73,615 postmenopausal women in the American Cancer Society Cancer Prevention Study II Nutrition Cohort, 4,760 women were diagnosed with breast cancer between 1992 and 2009. Extended Cox regression was used to estimate multivariable-adjusted relative risks (RR) of breast cancer in relation to total recreational physical activity, walking, and leisure-time sitting. Differences in associations by ER status, BMI, weight gain, and PMH use were also evaluated. The most active women (those reporting >42 MET-hours/week physical activity) experienced 25% lower risk of breast cancer than the least active [0-<7 MET-hours/week; 95% confidence interval (CI), 0.63-0.89; P trend ¼ 0.01]. Forty-seven percent of women reported walking as their only recreational activity; among these women, a 14% lower risk was observed for !7 hours/week relative to 3 hours/week of walking (95% CI, 0.

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“…and information about the consequences of sedentary behaviour is a relatively new area of research, but has been gaining traction 29 . Given the amount of time that cancer survivors spend engaged in sedentary behaviour 29 and the link between visual representation, body image, and motivation to participate in physical activity 31,32 , it seems prudent to present such information for bca survivors.…”

Section: Visual Representation Of Breast Cancer Survivorsmentioning

confidence: 99%

“…To that end, we first sought to determine the prevalence of specific physical activity information relevant to bca survivors, such as information about physical activity guidelines 27 and the effects of sedentary behaviour [28][29][30] , and the visual representations of bca survivors 31,32 , to gain a sense of the potential knowledge translation gap.…”

Section: Introductionmentioning

confidence: 99%

“…Canadians who are aware of physical activity guidelines are more active than their unaware counterparts 33 . Cancer survivors are more sedentary than people without cancer 28 , and sedentary behaviour is associated with lower quality of life and higher rates of mortality in cancer survivors 29 . Furthermore, providing tailored information for bca survivors is beneficial for increasing physical activity 34 , and the presence of physical activity guidelines, cautions against sedentary behaviour, and visual representations provides additional insight into whether contemporary, tailored knowledge about physical activity behaviour is being translated to bca survivors by Canadian cancer centre Web sites.…”

Section: Introductionmentioning

confidence: 99%

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An Evaluation of the Behaviour-Change Techniques Used on Canadian Cancer Centre Web Sites to Support Physical Activity Behaviour for Breast Cancer Survivors

et al. 2017

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Sedentary Behavior and Cancer: A Systematic Review of the Literature and Proposed Biological Mechanisms

Cited by 319 publications

References 147 publications

Prospective Examination of Objectively Assessed Physical Activity and Sedentary Time after Breast Cancer Treatment: Sitting on the Crest of the Teachable Moment

Prospective Examination of Objectively Assessed Physical Activity and Sedentary Time after Breast Cancer Treatment: Sitting on the Crest of the Teachable Moment

Recreational Physical Activity and Leisure-Time Sitting in Relation to Postmenopausal Breast Cancer Risk

An Evaluation of the Behaviour-Change Techniques Used on Canadian Cancer Centre Web Sites to Support Physical Activity Behaviour for Breast Cancer Survivors

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