Sedentary behaviour in young people presenting with a first episode of psychosis before and during the covid-19 pandemic restrictions

O’Donoghue, Brian; Castagnini, Emily; Langstone, Alison; Mifsud, Nathan; Thompson, Andrew; Killackey, Eóin; McGorry, Patrick D.

doi:10.1016/j.schres.2021.06.006

Cited by 3 publications

(1 citation statement)

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“…Therefore, the findings of this trial should still encourage early intervention services to adopt physical health interventions. Considering that this clinical population can be sedentary for at least 11 h of their waking day, 4 , 32 very intensive interventions are warranted. There is good evidence supporting the use of metformin to reduce weight gain associated with antipsychotic medication, 33 and as such, it is recommended in those who have experienced clinically significant weight gain.…”

Section: Discussionmentioning

confidence: 99%

A single-blind, randomised controlled trial of a physical health nurse intervention to prevent weight gain and metabolic complications in first-episode psychosis: the Physical Health Assistance in Early Psychosis (PHAstER) study

et al. 2022

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Background Factors that contribute to the early mortality observed in psychotic disorders, specifically obesity, smoking and sedentary behaviour, occur early in the disorder. Aims We aimed to determine whether the integration of a physical health nurse in the care of young people with first-episode psychosis could prevent clinically significant weight gain (≥7% body weight). Secondary outcomes included rates of smoking, metabolic syndrome and sedentary behaviour. Method In this single-blind, randomised controlled trial, participants who had received under 4 weeks of antipsychotic medication were randomly allocated to either the intervention (addition of a physical health nurse to their care) or treatment as usual (TAU) for 12 weeks. Results Of the 77 participants, there were follow-up data for 86.8% (n = 33) of the intervention group and 82.1% (n = 32) of the TAU group. After 12 weeks, 27.3% of the intervention group experienced clinically significant weight gain compared with 34.4% of the TAU group (odds ratio 0.72, 95% CI 0.25–2.06, P = 0.54). After 6 months, 40.7% of the intervention group gained clinically significant weight compared with 44.1% of the TAU group (P = 0.79). There was no difference in mean change in weight between groups after 12 weeks (2.6 kg v. 2.9 kg, P = 0.87) or 6 months (3.6 kg v. 4.3 kg, P = 0.64). There were no differences in the rates of tobacco smoking cessation, prevalence of metabolic syndrome or physical activity levels. Conclusions This intervention failed to prevent the metabolic complications that are highly prevalent in psychotic disorders in the short to medium term, indicating that more intensive interventions are required.

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Section: Discussionmentioning

confidence: 99%