Seeing beyond the symptoms: biomarkers and brain regions linked to cognitive decline in Alzheimer’s disease
Seyed Hani Hojjati,
Abbas Babajani-Feremi
Abstract:ObjectiveEarly Alzheimer’s disease (AD) diagnosis remains challenging, necessitating specific biomarkers for timely detection. This study aimed to identify such biomarkers and explore their associations with cognitive decline.MethodsA cohort of 1759 individuals across cognitive aging stages, including healthy controls (HC), mild cognitive impairment (MCI), and AD, was examined. Utilizing nine biomarkers from structural MRI (sMRI), diffusion tensor imaging (DTI), and positron emission tomography (PET), predicti… Show more
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