Seeking consistency for the role of urinary macromolecules and glycosaminoglycans in calcium oxalate crystallization processes pertaining to the risk of renal stone formation using a multi-faceted basic science approach

Jappie, Dalielah; Rodgers, Allen L.; Webber, Dawn; Gohel, Mayur Danny I.

doi:10.1016/j.cca.2021.06.027

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…However, a recent study found that HA inhibited aggregation of CaOx crystals in artificial urine, but did not have any effect on the crystalline properties of CaOx in real urine. In addition, it has been pointed out that the regulation of nucleation and growth of crystals in urine is the result of the combined action of various GAGs [261].…”

Section: Gags In Other Diseasesmentioning

confidence: 99%

The Alterations and Roles of Glycosaminoglycans in Human Diseases

Wang

2022

Polymers

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Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which are composed of a repeating disaccharide unit. They are also linked to core proteins to form proteoglycans (PGs). GAGs/PGs are major components of the cell surface and the extracellular matrix (ECM), and they display critical roles in development, normal function, and damage response in the body. Some properties (such as expression quantity, molecular weight, and sulfation pattern) of GAGs may be altered under pathological conditions. Due to the close connection between these properties and the function of GAGs/PGs, the alterations are often associated with enormous changes in the physiological/pathological status of cells and organs. Therefore, these GAGs/PGs may serve as marker molecules of disease. This review aimed to investigate the structural alterations and roles of GAGs/PGs in a range of diseases, such as atherosclerosis, cancer, diabetes, neurodegenerative disease, and virus infection. It is hoped to provide a reference for disease diagnosis, monitoring, prognosis, and drug development.

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Section: Gags In Other Diseasesmentioning

confidence: 99%

The Alterations and Roles of Glycosaminoglycans in Human Diseases

Wang

2022

Polymers

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“…22 Glycosaminoglycans (GAGs) are inhibitors of kidney stones in urine. 23 Hence, the concentration of GAGs in the urine of patients with kidney stones is often lower than those of healthy controls. 24 The molecular structure and physicochemical properties of seaweed polysaccharides are similar to GAGs.…”

Section: Introductionmentioning

confidence: 99%