Seeking research questions from implementers: considerations for leveraging ground actors research needs in the fight against malaria in West Africa

Amouh, Tete Sitou; Ekoye, Saidou Malam; Ahanhanzo, Césaire Damien; Guiguemdé, T. R.; Sombié, Issiaka

doi:10.1186/s12936-021-03634-0

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…The process used for this research prioritization effort aimed to build upon other recent malaria research prioritization efforts. The desk review revealed a few country- and regional-level malaria research agendas that included some similarly themed operational research questions [ 29 – 32 ]. However, most of these agendas were set between 2015 and 2017 and were thus somewhat outdated.…”

Section: Discussionmentioning

confidence: 99%

Defining operational research priorities to improve malaria control and elimination in sub-Saharan Africa: results from a country-driven research prioritization setting process

Tine,

Herrera,

Badji

et al. 2023

Malar J

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Background In order to reignite gains and accelerate progress toward improved malaria control and elimination, policy, strategy, and operational decisions should be derived from high-quality evidence. The U.S. President’s Malaria Initiative (PMI) Insights project together with the Université Cheikh Anta Diop of Dakar, Senegal, conducted a broad stakeholder consultation process to identify pressing evidence gaps in malaria control and elimination across sub-Saharan Africa (SSA), and developed a priority list of country-driven malaria operational research (OR) and programme evaluation (PE) topics to address these gaps. Methods Five key stakeholder groups were engaged in the process: national malaria programmes (NMPs), research institutions in SSA, World Health Organization (WHO) representatives in SSA, international funding agencies, and global technical partners who support malaria programme implementation and research. Stakeholders were engaged through individual or small group interviews and an online survey, and asked about key operational challenges faced by NMPs, pressing evidence gaps in current strategy and implementation guidance, and priority OR and PE questions to address the challenges and gaps. Results Altogether, 47 interviews were conducted with 82 individuals, and through the online survey, input was provided by 46 global technical partners. A total of 33 emergent OR and PE topics were identified through the consultation process and were subsequently evaluated and prioritized by an external evaluation committee of experts from NMPs, research institutions, and the WHO. The resulting prioritized OR and PE topics predominantly focused on generating evidence needed to close gaps in intervention coverage, address persistent challenges faced by NMPs in the implementation of core strategic interventions, and inform the effective deployment of new tools. Conclusion The prioritized research list is intended to serve as a key resource for informing OR and PE investments, thereby ensuring future investments focus on generating the evidence needed to strengthen national strategies and programme implementation and facilitating a more coordinated and impactful approach to malaria operational research.

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Section: Discussionmentioning

confidence: 99%

Defining operational research priorities to improve malaria control and elimination in sub-Saharan Africa: results from a country-driven research prioritization setting process

Tine,

Herrera,

Badji

et al. 2023

Malar J

View full text Add to dashboard Cite

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Pharmacovigilance reporting during seasonal malaria chemoprevention campaign: Findings from northern Nigeria

Aiden¹,

Dabes

Maduka

et al. 2022

Scientific African

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Spontaneous adverse drug reaction reporting during the seasonal malaria chemoprevention campaign in 2022

Rotimi,

Fagbemi,

Ibinaiye

et al. 2023

Bull Natl Res Cent

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Background Seasonal administration of antimalaria drug, sulphadoxine/pyrimethamine plus amodiaquine to children 3–59 months is a malaria preventive intervention used for the reduction of childhood malaria morbidity and mortality in area with highly seasonal malaria transmission like sub-Saharan Africa. This intervention has been deployed in Nigeria and other sub-Saharan African countries for years and may continue for more years to come either alone or combination with other novel interventions. Despite the importance of pharmacovigilance, there is currently a dearth of pharmacovigilance data in most African countries, especially in public health interventions like seasonal malaria chemoprevention campaigns. The availability of quality safety data is likely to improve the acceptability of this preventive intervention. Results The study identified vomiting as the most reported adverse drug reaction. Other reported reactions include weakness, fever, abdominal pain, convulsion, redness of the eyes, swollen hand/face, rash, itching, cough, headache, and excessive salivation. Using Naranjo scale, 69.2% of the reported reactions can be classified as possible; while 29.5% can be classified as probable, only 1.3% is classified as definite. 92.3% of reported adverse drug reactions were from children 12–59 months and 7.7% were from those 3–11 months. The proportion of ADRs classified according to the affected organ/system is as follows: central nervous system (10.26%), gastrointestinal (60.26%), ocular (10.26%), musculoskeletal (7.69%), and dermatological (11.53%). The study also suggests better tolerability to the seasonal malaria chemoprevention medicines with more implementation experience, as states with more implementation experiences reported fewer suspected adverse drug reactions. Conclusions The findings from this study provide additional information on possible adverse drug reactions during seasonal malaria chemoprevention campaigns. This additional information should be communicated to caregivers during the seasonal malaria chemoprevention campaigns as a way of building trust and improving acceptability of the intervention. Also, strengthening of the national pharmacovigilance system is vital to ensure improved timeliness, quality, and quantity of pharmacovigilance reporting on SMC intervention in Africa, as results from the study show low levels of pharmacovigilance reporting across the states.

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Seeking research questions from implementers: considerations for leveraging ground actors research needs in the fight against malaria in West Africa

Cited by 3 publications

References 10 publications

Defining operational research priorities to improve malaria control and elimination in sub-Saharan Africa: results from a country-driven research prioritization setting process

Defining operational research priorities to improve malaria control and elimination in sub-Saharan Africa: results from a country-driven research prioritization setting process

Pharmacovigilance reporting during seasonal malaria chemoprevention campaign: Findings from northern Nigeria

Spontaneous adverse drug reaction reporting during the seasonal malaria chemoprevention campaign in 2022

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