2001
DOI: 10.1164/ajrccm.164.5.2006082
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Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa

Abstract: Mast cells and basophils are cells that play an important role in the initiation and control of allergic inflammation in asthma and rhinitis. This study was undertaken to determine the presence and dynamics of mast cells and basophils in the nasal and bronchial mucosa of allergic rhinitis patients after segmental bronchial provocation (SBP). Eight nonasthmatic, grass pollen-allergic rhinitis patients and eight healthy controls were included. Bronchial and nasal biopsies, as well as blood samples, were taken be… Show more

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Cited by 183 publications
(127 citation statements)
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“…Blood eosinophils and interleukin (IL)-5 were also raised. This bidirectional cross-talk was evident when the same authors confirmed nasal inflammatory response after segmental bronchial allergen provocation in non-asthmatics with AR [24,25]. Typical early-and late-phase responses are also essential common features between AR and asthma [5].…”
Section: Pathophysiologic Evidencementioning
confidence: 76%
“…Blood eosinophils and interleukin (IL)-5 were also raised. This bidirectional cross-talk was evident when the same authors confirmed nasal inflammatory response after segmental bronchial allergen provocation in non-asthmatics with AR [24,25]. Typical early-and late-phase responses are also essential common features between AR and asthma [5].…”
Section: Pathophysiologic Evidencementioning
confidence: 76%
“…15,16 Patients with allergic rhinitis may frequently present with asthma symptoms or spirometric impairment. Indeed, impaired FEV 1 values may be detected in some patients with allergic rhinitis who also perceive nasal symptoms alone.…”
Section: Discussionmentioning
confidence: 99%
“…The concept of a ''unified airway'' has been proposed, based on epidemiological and physiological data suggesting that the upper and lower airways may be linked through local inflammatory processes [65,66]. Consistent with this hypothesis, recent studies of induced cough in humans have demonstrated enhancement of cough reflex sensitivity in the presence of rhinosinusitis.…”
Section: Question 13mentioning
confidence: 99%