Segmental longitudinal strain as the most accurate predictor of the patchy pattern late gadolinium enhancement in hypertrophic cardiomyopathy

Wabich, Elżbieta; Dorniak, Karolina; Zienciuk-Krajka, Agnieszka; Nowak, Radosław; Raczak, Grzegorz; Daniłowicz‐Szymanowicz, Ludmiła

doi:10.1016/j.jjcc.2020.11.004

Cited by 11 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results would postulate that this parameter with the cut-off value worse than −16% could be supplementary in revealing HCM patients with AF history; moreover, the combined analysis of 2D strains for LA and LV ( Table 4 ) could increase the probability of AF revealing and seems to be more valuable than using each of these parameters separately. Several studies highlighted the complex and unique mechanisms of rotation and twist and the role of those parameters in LV function in HCM patients [ 26 , 41 ]. However, in our study, these parameters did not differ between AF+ and AF− patient, which could be the consequence of small sample size; therefore, it is impossible to say that these parameters are not related to the risk of AF in HCM patients and should be verified in the further, bigger studies.…”

Section: Discussionmentioning

confidence: 99%

“…LV twist was obtained as the highest difference in degrees between the apical and basal rotation. LV torsion was defined as LV twist indexed by LV diastolic longitudinal length (the distance between the mitral annulus and the apex in end-diastole averaged from four-, two-, and three-chamber apical views) [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the role of LV assessment, in addition to LA, in AF prediction in HCM patients seems to be of great importance. In this issue, 2D STE is a well-proven technique, confirmed for the prediction of malignant ventricular arrhythmias [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ], exacerbation of heart failure [ 21 , 23 , 24 ], and revealing the areas of myocardial fibrosis [ 21 , 26 ]; however, almost none of them were dedicated to the role of LV strains in AF probability.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comprehensive Echocardiography of Left Atrium and Left Ventricle Using Modern Techniques Helps in Better Revealing Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy

et al. 2021

Self Cite

View full text Add to dashboard Cite

Atrial fibrillation (AF) is an important arrhythmia in hypertrophic cardiomyopathy (HCM). We aimed to explore whether a complex evaluation of the left ventricle (LV) using modern echocardiography techniques, in addition to the left atrium (LA boosts), could improved the probability of AF diagnosis. Standard echocardiography, 2D and 3D speckle tracking, were performed for LA and LV evaluation in HCM patients and healthy volunteers. Of 128 initially qualified HCM patients, 60 fulfilled included criteria, from which 43 had a history of AF, and 17 were without AF. LA volume index and peak strain, LV ejection fraction, and strains were significant predictors of AF. In addition, 2D global longitudinal strain (GLS) for LV at cut off −16% turned out to be the most accurate predictor of AF (OR 48.00 [95% CI 2.68–859.36], p = 0.001), whereas the combination of LA peak strain ≤ 22% and LV GLS ≥ −16% had the highest discriminatory power (OR 76.36 [95% CI 4.13–1411.36], p = 0.001). AF in HCM patients seems to be LA as well as LV disease. Revealing lower strain for LV, in addition to lower LA strain, may have an important impact on accurate characteristics of HCM patients with AF history.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive Echocardiography of Left Atrium and Left Ventricle Using Modern Techniques Helps in Better Revealing Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although the extent of strain abnormalities and their regional expressions vary according to the degree of hypertrophy, they may also be pathological in segments with relatively normal wall thickness, most likely due to underlying disarray or fibrosis. Given the patchy distribution of fibrosis in HCM, as explained below in Section 2.3 , a segmental analysis of the LV longitudinal strain may be even more accurate in assessing fibrosis than a global evaluation: in a cohort of 46 HCM patients, Wabich et al recently demonstrated that segmental, rather than the GLS, with a cut-off value of −12.5%, has a higher sensitivity for the identification of LGE on CMR, and can help identify patients who need CMR referral for better risk stratification [ 10 ].…”

Section: An Overview Of the Main Imaging Techniques In Hypertrophic C...mentioning

confidence: 99%

Multimodality Imaging in Sarcomeric Hypertrophic Cardiomyopathy: Get It Right…on Time

Galluzzo¹,

Fiorelli

Rossi

et al. 2023

Life

View full text Add to dashboard Cite

Hypertrophic cardiomyopathy (HCM) follows highly variable paradigms and disease-specific patterns of progression towards heart failure, arrhythmias and sudden cardiac death. Therefore, a generalized standard approach, shared with other cardiomyopathies, can be misleading in this setting. A multimodality imaging approach facilitates differential diagnosis of phenocopies and improves clinical and therapeutic management of the disease. However, only a profound knowledge of the progression patterns, including clinical features and imaging data, enables an appropriate use of all these resources in clinical practice. Combinations of various imaging tools and novel techniques of artificial intelligence have a potentially relevant role in diagnosis, clinical management and definition of prognosis. Nonetheless, several barriers persist such as unclear appropriate timing of imaging or universal standardization of measures and normal reference limits. This review provides an overview of the current knowledge on multimodality imaging and potentialities of novel tools, including artificial intelligence, in the management of patients with sarcomeric HCM, highlighting the importance of specific “red alerts” to understand the phenotype–genotype linkage.

show abstract

“…Global and segmental strain could respectively stratify different extent and transmurality of LGE in patients with ST-segment elevation MI, and the surrounding areas of the infarcted core without LGE had impaired strains ( 129 ). Segmental rather than global longitudinal strain, especially septal longitudinal strain, was associated with histological fibrosis in HCM and provided incremental values over LGE to detect myocardial fibrosis ( 130 , 131 ). In addition, the value of CMR strain parameters for risk stratification has also been reported ( 10 , 132 ).…”

Section: Detection: Laboratory Biomarkers and Imaging Techniquesmentioning

confidence: 99%

Detection of myocardial fibrosis: Where we stand

Zhu

Zhao

Lü

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Myocardial fibrosis, resulting from the disturbance of extracellular matrix homeostasis in response to different insults, is a common and important pathological remodeling process that is associated with adverse clinical outcomes, including arrhythmia, heart failure, or even sudden cardiac death. Over the past decades, multiple non-invasive detection methods have been developed. Laboratory biomarkers can aid in both detection and risk stratification by reflecting cellular and even molecular changes in fibrotic processes, yet more evidence that validates their detection accuracy is still warranted. Different non-invasive imaging techniques have been demonstrated to not only detect myocardial fibrosis but also provide information on prognosis and management. Cardiovascular magnetic resonance (CMR) is considered as the gold standard imaging technique to non-invasively identify and quantify myocardial fibrosis with its natural ability for tissue characterization. This review summarizes the current understanding of the non-invasive detection methods of myocardial fibrosis, with the focus on different techniques and clinical applications of CMR.

show abstract

Segmental longitudinal strain as the most accurate predictor of the patchy pattern late gadolinium enhancement in hypertrophic cardiomyopathy

Cited by 11 publications

References 30 publications

Comprehensive Echocardiography of Left Atrium and Left Ventricle Using Modern Techniques Helps in Better Revealing Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy

Comprehensive Echocardiography of Left Atrium and Left Ventricle Using Modern Techniques Helps in Better Revealing Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy

Multimodality Imaging in Sarcomeric Hypertrophic Cardiomyopathy: Get It Right…on Time

Detection of myocardial fibrosis: Where we stand

Contact Info

Product

Resources

About