Segmentation: Painting stripes from flies to vertebrates

Pick, Leslie

doi:10.1002/(sici)1520-6408(1998)23:1<1::aid-dvg1>3.0.co;2-a

Cited by 24 publications

(2 citation statements)

References 123 publications

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“…Interestingly, two distinct enhancers that independently regulate Ser expression in the femur and in the tarsus have been identified (Rauskolb 2001). Considering all of these observations, it seems that each ring of Notch ligands and fng expression may be individually regulated by different combinations of PD genes using different enhancers, as in the case of the regulation of pair‐rule gene expression during embryonic segmentation (Small & Levine 1991; Pick 1998).…”

Section: The Formation Of Joints Between Leg Segmentsmentioning

confidence: 99%

The mechanism of Drosophila leg development along the proximodistal axis

2004

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During development of higher organisms, most patterning events occur in growing tissues. Thus, unraveling the mechanism of how growing tissues are patterned into final morphologies has been an essential subject of developmental biology. Limb or appendage development in both vertebrates and invertebrates has attracted great attention from many researchers for a long time, because they involve almost all developmental processes required for tissue patterning, such as generation of the positional information by morphogen, subdivision of the tissue into distinct parts according to the positional information, localized cell growth and proliferation, and control of adhesivity, movement and shape changes of cells. The Drosophila leg development is a good model system, upon which a substantial amount of knowledge has been accumulated. In this review, the current understanding of the mechanism of Drosophila leg development is described.

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Section: The Formation Of Joints Between Leg Segmentsmentioning

confidence: 99%

The mechanism of Drosophila leg development along the proximodistal axis

2004

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“…For example, in the development of the Drosophila embryo, the establishment of the anterior and posterior pole is followed by a sequential series of patterning events that finally produce the different specialized segments of the adult body in the correct spatial arrangement (Pick, 1998). In the case of C. elegans, the hierarchical organization of development is reflected in an invariant sequence of cell divisions and cell differentiation events, resulting in a stereotyped fate map for each individual cell of the body (Labouesse and Mango, 1999).…”

Section: Discussionmentioning

confidence: 99%

Regulation of phyllotaxis

Reinhardt¹

2005

Int. J. Dev. Biol.

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Plant architecture is characterized by a high degree of regularity. Leaves, flowers and floral organs are arranged in regular patterns, a phenomenon referred to as phyllotaxis. Regular phyllotaxis is found in virtually all higher plants, from mosses, over ferns, to gymnosperms and angiosperms. Due to its remarkable precision, its beauty and its accessibility, phyllotaxis has for centuries been the object of admiration and scientific examination. There have been numerous hypotheses to explain the nature of the mechanistic principle behind phyllotaxis, however, not all of them have been amenable to experimental examination. This is due mainly to the delicacy and small size of the shoot apical meristem, where plant organs are formed and the phyllotactic patterns are laid down. Recently, the combination of genetics, molecular tools and micromanipulation has resulted in the identification of auxin as a central player in organ formation and positioning. This paper discusses some aspects of phyllotactic patterns found in nature and summarizes our current understanding of the regulatory mechanism behind phyllotaxis.

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Dynamics of Polycomb and Trithorax activities during development

Soshnikova

2011

Birth Defects Research

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Dynamic changes in gene expression are tightly controlled during development, as a single totipotent zygote gives rise to distinct cell lineages. The establishment and maintenance of these diverse transcriptional programs rely on changes of chromatin state, mainly through histone modifications. Polycomb and Trithorax complexes participate in setting apart active and inactive genes by respectively repressing and activating key developmental regulators in different cell types. Over the last decade, our understanding of the biochemical mechanisms underlying their activities has greatly improved, but the signals targeting these proteins to specific regions of the genome are still poorly understood, particularly in vertebrates. Recent findings highlight the highly dynamic activities of Polycomb and Trithorax complexes in vivo. Surprisingly, although their role in transcriptional regulation is deeply conserved during evolution, the time sequence in which they act seems to vary across species.

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Segmentation: Painting stripes from flies to vertebrates

Cited by 24 publications

References 123 publications

The mechanism of Drosophila leg development along the proximodistal axis

The mechanism of Drosophila leg development along the proximodistal axis

Regulation of phyllotaxis

Dynamics of Polycomb and Trithorax activities during development

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