Segmented poly(esterurethane urea)s from novel urea–diol chain extenders: Synthesis, characterization and in vitro biological properties

Caracciolo, Pablo C.; Queiroz, Álvaro Antônio Alencar de; Higa, Olga Zazuco; Buffa, Fabián Alejandro; Abraham, Gustavo Abel

doi:10.1016/j.actbio.2008.02.016

Cited by 44 publications

(30 citation statements)

References 30 publications

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“…Also, a large number of these polyurethanes are biodegradable polymers with a wide variety of chemical and mechanical properties which make them useful in biomedical applications [5][6][7][8][9][10]. The wide range of polyurethane elastomer properties are directly linked to their two-phase microstructure, with hard domains acting as thermally reversible crosslinking points [11]. The introduction of chemical crosslinks changes the chemical, physical and mechanical properties of polyurethane elastomers [12].…”

Section: Introductionmentioning

confidence: 99%

Novel quinoline-based polyurethane elastomers. The effect of the hard segment structure in properties enhancement

Oprea¹

2011

J Polym Res

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Polyurethane elastomers incorporating a quinoline moiety along their polymeric backbones and aliphatic, aromatic or heterocyclic crosslinkers have been synthesized and characterized. For this, NCO-terminated urethane oligomers were prepared from poly(butylene adipate) diol and methylene diphenyl diisocyanate and were subsequently chain extended with 2,4-quinolinediol and different crosslinkers. This study reports the influence of the different crosslinker chemical structures and the hard segment molar ratio on the thermal and dynamic mechanical thermal properties, as well as on the mechanical properties of these elastomers. The fluorescence spectra of polyurethane elastomers were determined at an excitation wavelength of 290 nm. The different chemical structures of the crosslinkers determine the hard segment cohesion and reduce the mobility of the soft phase, having an important effect on thermal stability and on the mechanical properties of the polyurethane films. Thus the incorporation of aromatic crosslinkers results in polyurethanes with lower elongation and stress at break. The highest mechanical properties were obtained for polyurethanes crosslinked with aliphatic crosslinkers.

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Section: Introductionmentioning

confidence: 99%

Novel quinoline-based polyurethane elastomers. The effect of the hard segment structure in properties enhancement

Oprea¹

2011

J Polym Res

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“…36 The whole human blood was added to one part of acid-citrate-dextrose (ACD) for nine parts of blood. The resultant ACD blood was placed on a glass plate and to epoxies networks surfaces.…”

Section: Thrombus Formationmentioning

confidence: 99%

“…[33][34][35][36][37][38] Many studies have examined the cytotoxicity in vitro of epoxy networks [15][16][17][18] as well as their monomeric precursors. [38][39][40][41] They use different cell lines, a variety incubation times (hours to days), and various assay methods.…”

Section: Cytotoxicity Measurementsmentioning

confidence: 99%

Epoxy networks for medicine applications: Mechanical properties and in vitro biological properties

García

Leyva

Queiroz

et al. 2009

J of Applied Polymer Sci

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This work describes the physicochemical, mechanical, and in vitro biological properties of three epoxy networks based on diglycidyl ether of bisphenol-A (DGEBA) epoxy prepolymer cured with triethylenetetramine, 1-(2-aminoethyl)piperazine (AEP) and isophoronediamine. The mechanical properties were evaluated with respect to impact and flexural tests. Functionality rules the mechanical behavior of epoxy networks by increasing the crosslink density and the flexural modulus, increasing T g and decreasing the chain flexibility and the impact resistance. The biological interactions between the obtained epoxy polymers and blood were studied by in vitro methods. Studies on the protein adsorption, platelet adhesion, and thrombus formation are presented. The protein adsorption assays onto polymeric surfaces showed that the epoxy networks adsorbed more albumin than fibrinogen. The results about platelet adhesion and thrombus formation indicated that DGEBA-IPD and DGEBA-AEP networks exhibits good hemocompatible behavior. The materials revealed no signs of cytotoxicity to Chinese hamster ovary cells, showing a satisfactory cytocompatibility. In this way, we can assume that the epoxy polymers are biocompatible materials.

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“…The polyurethaneurea (PUU) are used in a variety of medical applications, such as the wound dressing [1], contact lenses [2], catheters, prostheses, blood vessels [3], antithrombogenous products [4], mechanically supporting constructions during the soft tissue reconstruction [5], metal stents coating of atherosclerotic blood vessels [6], surgical meshes [7,8] and bone tissue engineered [9,10], vascular tissue engineering [11].…”

Section: Introductionmentioning

confidence: 99%

Hydrophylic Polyurethaneurea Containing the Copolymer of N-vinylpyrrolidone, Vinyl Acetate and Vinyl Alcohol for Possible Biomedical Use

Rudenchyk¹

2017

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Abstract:The series of polyurethaneurea (PUU) containing in its structure the fragments of the copolymer of Nvinylpyrrolidone, vinyl acetate and vinyl alcohol (VP-VA) with the 1.6-hexamethylenediamine (HMDA) macrochain extender and the series of PUU with the 4.4'-diaminodiphenylmethane (DADPh) macrochain extender having different ratio of HMDA and DADPh to 40:60; 50:50; 60:40; 70:30) were synthesized. It has been established that PUU containing in its structure the DADPh macrochain extender is characterized by higher values of the tensile strength and relative elongation at break, glass-transition temperature and the change of the specific heat capacity and hydrophilicity compared to PUU containing in its structure the HMDA macrochain extender. It was found that the increase in amount of VP-VA copolymers in PUU structure increases hydrophilicity by 19-41% for PUU with HMDA and by 16-62% for PUU with DADPh and will contribute to a prolonged release of biologically active substances from the polymer matrix. The results obtained allowed us to determine that the PUU with VP-VA copolymer fragments in the structure synthesized with the ratio of HMDA and DADPh to VP-VA 70:30 is characterized by sufficient physical-mechanical properties (σ = 3.1 MPa, ε = 47% and σ = 5.2 MPa, ε = 90%, accordingly), hydrophilicity (21.0% and 19.4%, accordingly) and can be used as a polymer matrix for medicine biologically active composite materials.

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Segmented poly(esterurethane urea)s from novel urea–diol chain extenders: Synthesis, characterization and in vitro biological properties

Cited by 44 publications

References 30 publications

Novel quinoline-based polyurethane elastomers. The effect of the hard segment structure in properties enhancement

Novel quinoline-based polyurethane elastomers. The effect of the hard segment structure in properties enhancement

Epoxy networks for medicine applications: Mechanical properties and in vitro biological properties

Hydrophylic Polyurethaneurea Containing the Copolymer of N-vinylpyrrolidone, Vinyl Acetate and Vinyl Alcohol for Possible Biomedical Use

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