Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy

Coan, Ana Carolina; Appenzeller, Simone; Bonilha, Leonardo; Li, Li Min; Cendes, Fernando

doi:10.1212/wnl.0b013e3181b783dd

Cited by 166 publications

(181 citation statements)

References 36 publications

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“…In addition, patients with L‐MTLE presented as hubs of relative decreased connectivity the dorsal DMN (r4n4) and the right ECN (r2n7). The idea that the L‐MTLE patients are more susceptible to bilateral and diffuse structural alterations was already described in the literature [Ahmadi et al, 2009, Coan et al, 2009] and our study suggests that these patterns occurs also with the functional organization, involving contralateral networks. These findings are sustained by the laterality index that showed more ipsilateral‐restricted alterations on R‐MTLE, while the L‐MTLE presented a more bilateral pattern of alterations.…”

Section: Discussionsupporting

confidence: 80%

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Campos

Coan

Yasuda

et al. 2016

Human Brain Mapping

109

102

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Mesial temporal lobe epilepsy (MTLE) with hippocampus sclerosis (HS) is associated with functional and structural alterations extending beyond the temporal regions and abnormal pattern of brain resting state networks (RSNs) connectivity. We hypothesized that the interaction of large‐scale RSNs is differently affected in patients with right‐ and left‐MTLE with HS compared to controls. We aimed to determine and characterize these alterations through the analysis of 12 RSNs, functionally parceled in 70 regions of interest (ROIs), from resting‐state functional‐MRIs of 99 subjects (52 controls, 26 right‐ and 21 left‐MTLE patients with HS). Image preprocessing and statistical analysis were performed using UF2C‐toolbox, which provided ROI‐wise results for intranetwork and internetwork connectivity. Intranetwork abnormalities were observed in the dorsal default mode network (DMN) in both groups of patients and in the posterior salience network in right‐MTLE. Both groups showed abnormal correlation between the dorsal‐DMN and the posterior salience, as well as between the dorsal‐DMN and the executive‐control network. Patients with left‐MTLE also showed reduced correlation between the dorsal‐DMN and visuospatial network and increased correlation between bilateral thalamus and the posterior salience network. The ipsilateral hippocampus stood out as a central area of abnormalities. Alterations on left‐MTLE expressed a low cluster coefficient, whereas the altered connections on right‐MTLE showed low cluster coefficient in the DMN but high in the posterior salience regions. Both right‐ and left‐MTLE patients with HS have widespread abnormal interactions of large‐scale brain networks; however, all parameters evaluated indicate that left‐MTLE has a more intricate bihemispheric dysfunction compared to right‐MTLE. Hum Brain Mapp 37:3137–3152, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 80%

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Campos

Coan

Yasuda

et al. 2016

Human Brain Mapping

109

102

View full text Add to dashboard Cite

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“…Through the current study, it can be said that the findings are also valid for the epilepsy group. The study carried out by Bostanci et al, showing the clinical findings that become dissimilar when major depression accompanies epilepsy, also supports our findings (25). However, the small number of cases in our study prevents the hypotheses from being fully proven.…”

Section: Association Of Depression With Temps-a Scoressupporting

confidence: 88%

“…Long illness duration and frequent seizures in epilepsy are associated with higher degrees of atrophy in white and gray matter (25).…”

Section: Association Of Clinical Findings and Personality Traits Of Ementioning

confidence: 99%

Affective Temperaments in Epilepsy

Yazıcı¹,

Yazıcı²,

Varoğlu³

et al. 2012

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…One study followed a multicohort design with a median interscan interval of 3.3 years, but without statistically comparing patients to controls. 43 Three analyses reported parametric modulations of change trajectories by measures of seizure frequency. 27,43,44 Systematic review and meta-analysis on progressive hippocampal atrophy.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy

et al. 2017

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Objective: It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence.Methods: We conducted a systematic review and meta-analysis of MRI studies on progressive atrophy, searching PubMed and Ovid MEDLINE databases for cross-sectional and longitudinal quantitative MRI studies on drug-resistant TLE.Results: We screened 2,976 records and assessed eligibility of 248 full-text articles. Forty-two articles met the inclusion criteria for quantitative evaluation. We observed a predominance of cross-sectional studies, use of different clinical indices of progression, and high heterogeneity in age-control procedures. Meta-analysis of 18/1 cross-sectional/longitudinal studies on hippocampal atrophy (n 5 979 patients) yielded a pooled effect size of r 5 20.42 for ipsilateral atrophy related to epilepsy duration (95% confidence interval [CI] 20.51 to 20.32; p , 0.0001; I 2 5 65.22%) and r 5 20.35 related to seizure frequency (95% CI 20.47 to 20.22; p , 0.0001; I 2 5 61.97%). Sensitivity analyses did not change the results. Narrative synthesis of 25/3 crosssectional/longitudinal studies on whole brain atrophy (n 5 1,504 patients) indicated that .80% of articles reported duration-related progression in extratemporal cortical and subcortical regions. Detailed analysis of study design features yielded low to moderate levels of evidence for progressive atrophy across studies, mainly due to dominance of cross-sectional over longitudinal investigations, use of diverse measures of seizure estimates, and absence of consistent age control procedures.

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Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy

Abstract: The progression of white and gray matter atrophy in patients with mesial temporal lobe epilepsy (MTLE) was more intense in patients with left MTLE and was associated with poorer seizure control and a longer duration of epilepsy.

Cited by 166 publications

References 36 publications

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Affective Temperaments in Epilepsy

A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy

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