Seizures and bupropion

Davidson, June F.

doi:10.1097/00004714-199002000-00018

Cited by 26 publications

(34 citation statements)

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“…Similarly, increasing the BUP dose from 10 to 20 mg/kg caused a significant reduction in food intake from 10 mg/kg, but no significant change in activity (**Po0.01 and ***Po0.001). In pilot studies, a dose of 160 mg/kg appeared to produce seizures in some animals, as has been reported for high doses of this drug (Davidson, 1989). Therefore, 80 mg/ kg was chosen for the highest dose to be tested; this dose did not produce seizures in any animals.…”

Section: Analysis Of Drug Additivity/synergymentioning

confidence: 88%

Inhibition of Dopamine and Norepinephrine Reuptake Produces Additive Effects on Energy Balance in Lean and Obese Mice

Billes

Cowley

2006

Neuropsychopharmacol

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Although originally developed as an antidepressant, long-term bupropion (BUP) treatment was recently shown to cause 5-8% weight loss over placebo in clinical trials with obese adults. BUP's antidepressant properties probably stem from its ability to increase extracellular brain dopamine (DA) and norepinephrine (NE) levels by inhibiting their reuptake, although the mechanism of BUP-induced weight loss is unknown. Consequently, the acute effects of DA and NE reuptake inhibition on energy homeostasis were determined by measuring food intake and body weight in mice following peripheral (intraperitoneal (i.p.)) administration of either BUP, a selective DA (GBR12783), or a selective NE (nisoxetine (NIS)) reuptake inhibitor. BUP, GBR12783, and NIS all dose-dependently decreased acute food intake in fasted lean mice. The ability of BUP to decrease food intake was independent of its ability to cause a temporary increase in locomotor activity. The inhibitory effects of acute GBR12783 and NIS on short-term food intake were additive. Subchronic (via miniosmotic pump) administration of GBR12783 and NIS produced a transient nonadditive effect on food intake, but produced an additive reduction in body weight (8-10%). Because obesity can affect catecholaminergic signaling, we determined the effects of i.p. BUP, GBR12783, and NIS on short-term food intake in obese mice. Acute BUP, GBR12783, and NIS dose-dependently reduced acute food intake, and the additive effect of GBR12783 and NIS on acute food intake was preserved in obese mice. These results demonstrate that combined DA and NE reuptake inhibition produces additive effects on energy balance in lean and obese mice on both standard and high-fat diet, providing a foundation for further research on the effects of BUP and similar compounds on energy balance in mice.

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Section: Analysis Of Drug Additivity/synergymentioning

confidence: 88%

Inhibition of Dopamine and Norepinephrine Reuptake Produces Additive Effects on Energy Balance in Lean and Obese Mice

Billes

Cowley

2006

Neuropsychopharmacol

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“…Bu risk; günlük 100-300 mg dozunda %0.1, 300-450 mg dozunda %0.4, 600 mg dozunda %2 olarak tespit edilmiştir. Özellikle tedavinin ilk 8 haftasında nöbet görülme sıklığı artmıştır [4,6].…”

Section: Discussionunclassified

“…Bupropion; Trisiklik antidepresanlar (TSA) ve Monoamin oksidaz inhibitörleri (MAOİ)de olduğu gibi epilepsi eşiğini düşürebilmektedir. Toplumda ilk epileptik atak sıklığı %0.07-0.09 olarak bildirilirken, günlük 450 mg ve altı hızlı salınımlı bupropion alımında bu oran %0.35-0.44 olarak bildirilmiştir [6]. Nöbet riskinin kanda pik düzeyi, pik düzeyi sayısı ve yüksek dozla ilişkili olduğu bildirilmiş olup bunun üzerine 2003' de kullanıma uzun yarı ömürlü yavaş salınımlı formu sunulmuştur ve yavaş salınımlı forma bağlı nöbetin nadir olduğu bildirilmiştir [7].…”

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“…Literatürde bupropionun yavaş salınımlı formuna bağlı epileptik nöbetler genellikle jeneralize tonik klonik nöbet şeklinde olup, olgu bildirimleri şeklindedir [4,6]. Bu yazıda bupropion HCI yavaş salınımlı tablet kullanımı bağlı gece spontan orgazmla ortaya çıkan, EEG' de patoloji saptanan, ilaç kesimiyle kliniği ve EEG bulgusu düzelen bir olgunun sunulması amaçlanmıştır.…”

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Orgasm During Sleep: Bupropione induced Seizure

Şengül¹,

Hanci²

2014

Pau Med J

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ÖzetBupropionun epiletik nöbet ile ilişkili olduğu bilinmektedir, fakat ilacın yavaş salınımlı formuna bağlı nöbet nadir görülmektedir, şu ana kadar bupropion kullanımı sırasında epilepsi geliştiği bildirilen olgular çoğunlukla jeneralize tonik klonik formdadır. Biz burada bupropiona bağlı iktal orgazm gelişen bir olgu sunmaktayız.Pam Med J 2014;7(2):155-157 Anahtar sözcükler: Bupropion, nöbet, uyku ilişkili, orgazmik epilepsi AbstractIt is known that bupropion is associated with epileptic seizure but seizures are rarely seen with the slow released form of the drug. To this day, case reports show that the generalized tonic clonic form is the form of epilepsy usually seen in bupropion associated epilepsy. Here, we present a case of ictal orgasm associated with bupropion. 2014;7(2):155-157 Pam Tıp Derg

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“…Although neither MRI displayed the multifocal enhancing white matter lesions associated typically with ADEM, it is unknown whether very early treatment with high-dose steroids might impact MRI findings of ADEM. Other potential etiologies for development of a seizure in this patient include bupropion use (8,9). Investigation of this case is ongoing.…”

Section: Reported By: Smallpox Vaccine Adverse Events Coordinators Nmentioning

confidence: 94%

Severe Acute Respiratory Syndrome—Taiwan, 2003

2003

JAMA

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Seizures and bupropion

Cited by 26 publications

References 0 publications

Inhibition of Dopamine and Norepinephrine Reuptake Produces Additive Effects on Energy Balance in Lean and Obese Mice

Inhibition of Dopamine and Norepinephrine Reuptake Produces Additive Effects on Energy Balance in Lean and Obese Mice

Orgasm During Sleep: Bupropione induced Seizure

Severe Acute Respiratory Syndrome—Taiwan, 2003

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