Selected Molecular Events in the Pathogenesis of Sarcoidosis—Recent Advances

Kiszałkiewicz, Justyna; Piotrowski, Wojciech J.; Brzeziańska-Lasota, Ewa

doi:10.5603/piap.2015.0076

Cited by 11 publications

(7 citation statements)

References 128 publications

(163 reference statements)

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“…There is not much documentation for this association. The inflammation in sarcoidosis is similar to CD; granulomatous; Th1 and 17 driven; and mutations in NOD2 and IL 23 receptor gene are identified[ 2 , 69 - 71 ].…”

Section: Discussionmentioning

confidence: 99%

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

Halling¹,

Kjeldsen²,

Knudsen³

et al. 2017

WJG

189

126

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AIMTo investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD).METHODSIn this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis (UC), Crohn’s disease (CD) and Both the latter referring to those registered with both diagnoses. Subsequently, odds-ratios (OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher’s exact test.RESULTSThere were significantly more women than men in the registry, and a greater percentage of comorbidity in the IBD groups (P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased (P < 0.00125) for primary sclerosing cholangitis (PSC), celiac disease, type 1 diabetes (T1D), sarcoidosis, asthma, iridocyclitis, psoriasis, pyoderma gangrenosum, rheumatoid arthritis, and ankylosing spondylitis. Restricted to UC (P < 0.00125) were autoimmune hepatitis, primary biliary cholangitis, Grave’s disease, polymyalgia rheumatica, temporal arteritis , and atrophic gastritis. Restricted to CD (P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC (P < 0.00125) were atrophic gastritis, rheumatoid arthritis, temporal arteritis, and polymyalgia rheumatica. Restricted to women with CD were episcleritis, rheumatoid arthritis, and psoriatic arthritis. The only disease restricted to men (P < 0.00125) was sarcoidosis.CONCLUSIONImmune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some IMDs and IBD may have overlapping pathogenic pathways.

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Section: Discussionmentioning

confidence: 99%

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

Halling¹,

Kjeldsen²,

Knudsen³

et al. 2017

WJG

189

126

View full text Add to dashboard Cite

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“…Although the etiology of sarcoidosis remains highly elusive, it is conventionally believed to derive from an interaction between environmental antigens and genetic factors (the genetic–environmental theory). 13 ACCESS, a US-based multicenter epidemiologic study of 706 clinically and histologically confirmed subjects with sarcoidosis, failed to identify a single predominant environmental, infective, or occupational “cause” of sarcoidosis. 14 This large case–control study suggests that multiple environmental sources of exposure may trigger an aberrant immunomediated granulomatous response in genetically susceptible individuals.…”

Section: Pathogenesis and Geneticsmentioning

confidence: 99%

“… 18 , 19 There appears to be a strong association between certain human leukocyte antigen (HLA) alleles and sarcoidosis susceptibility and disease behaviour. 12 , 13 Both HLA class I and II human leukocyte antigens have been implicated, with HLA class II genes reported to be more strongly and consistently associated. Certain alleles, such as HLA-DRB1 (HLA-DRB1*11, *12, *14, *15) are principally correlated with susceptibility, disease phenotype, and prognosis.…”

Section: Pathogenesis and Geneticsmentioning

confidence: 99%

Management of chronic ocular sarcoidosis: challenges and solutions

Matsou

Tsaousis

2018

OPTH

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BackgroundSarcoidosis constitutes one of the leading causes of ocular inflammation. Chronic ocular sarcoidosis can affect any segment of the eye and its adnexa, producing a wide range of clinical manifestations and severity. If left untreated, permanent visual impairment or even blindness may ensue. Treatment approaches vary from topical therapy to systemic agents that induce immunosuppression to different levels according to disease severity.ObjectiveTo review the published literature on the management options for chronic ocular sarcoidosis and provide a comprehensive list of available treatment strategies, including the newer biologics.SummaryOcular disease remains a challenging aspect of sarcoidosis and may even be the presenting sign of the disease. Prompt and effective therapy may reverse visual damage and prevent permanent loss of vision. Because of the complexity of the disease, a multidisciplinary approach is often required, with a view to addressing both the ocular and other systemic manifestations of sarcoidosis. Recent data suggest that achieving overall optimal systemic control is of paramount importance in controlling eye inflammation as well. Cytotoxic immunosuppressive agents for refractory chronic ocular disease, as well as biologic anti-TNFα therapies, have advanced the management of chronic disease and should be considered corticosteroid-sparing strategies before the onset of significant steroid-induced morbidity.

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“…The peak age of onset is between the second and the fourth decades of life. The incidence of sarcoidosis in Poland is estimated at approximately 10 cases per 100 thousand citizens (the worldwide incidence is 1-64/100 000; the highest incidence is observed in Scandinavian countries and among Afro-Americans in the USA, while the lowest is found in Singapore and Japan) [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Nursing care of a patient with sarcoidosis. Case study using ICNP^®

Brzeźnicki¹,

Grabowska²

2019

Pielegniarstwo XXI Wieku / Nursing in the 21st Century

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Introduction. Sarcoidosis is a rare, multi-organ disease of unknown etiology, characterized by the formation of granulomas mainly in the respiratory system.Aim. The aim of the study is to present a plan of care for patients with sarcoidosis, including International Classification for Nursing Practice – ICNP® terminology.Material and methods. The study was conducted in April 2019 at the Internal Disease Unit of the 7th Polish Navy Hospital in Gdansk, and included a 54-year-old patient hospitalized for sarcoidosis. The research employed the case study method and the technique of the interview, observation, analysis of medical records and measurements. The C-HOBIC data set was used to assess the patient’s condition.Results and conclusions. The reasons for the patient’s admission to the hospital were a continued raised temperature, erythema, as well as joint pain. The assessment and analysis of a patient’s status allowed us to formulate seven nursing diagnoses characteristic for sarcoidosis, which included: arthritis pain, functional dyspnoea, fever, impaired active range of motion, fatigue, risk for medication side effect and lack of knowledge of disease and 2 diagnoses resulting from the lifestyle of the patient: tobacco abuse and overweight. The process of nursing care planning included interventions fundamental for the above-mentioned diagnoses. They concerned the monitoring of symptoms and health indices, the patient’s knowledge, as well as the role of the nurse in the therapeutic process. The ICNP dictionary includes a sufficient range of terms, which allows the creation of a satisfactory nursing care plan for a patient with sarcoidosis.

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Selected Molecular Events in the Pathogenesis of Sarcoidosis—Recent Advances

Cited by 11 publications

References 128 publications

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

Management of chronic ocular sarcoidosis: challenges and solutions

Nursing care of a patient with sarcoidosis. Case study using ICNP^®

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Selected Molecular Events in the Pathogenesis of Sarcoidosis—Recent Advances

Cited by 11 publications

References 128 publications

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases

Management of chronic ocular sarcoidosis: challenges and solutions

Nursing care of a patient with sarcoidosis. Case study using ICNP®

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Product

Resources

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Nursing care of a patient with sarcoidosis. Case study using ICNP^®