Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14–18, 2012

Anderson‐Schmidt, Heike; Beltcheva, Olga; Brandon, Mariko; Byrne, Enda M.; Diehl, Eric J.; Duncan, Laramie; Gonzalez, Suzanne; Hannon, Eilís; Kantojärvi, Katri; Karagiannidis, Iordanis; Kos, Mark Z.; Kótyuk, Eszter; Laufer, Benjamin I.; Mantha, Katarzyna; McGregor, Nathaniel W.; Meier, Sandra; Nieratschker, Vanessa; Spiers, Helen; Squassina, Alessio; Thakur, Geeta; Tiwari, Yash; Viswanath, Biju; Way, Michael; Wong, Cybele C.P.; O’Shea, Anne; DeLisi, Lynn E.

doi:10.1002/ajmg.b.32132

Cited by 8 publications

(5 citation statements)

References 108 publications

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“…They were tasked to summarize individual sessions as well as relevant discussions. Similar accounts of the 2007, 2008, 2009, 2010, 2011, 2012, 2013, and 2014 congress held in New York (New York), Osaka (Japan), San Diego (California), Athens (Greece), Washington (District of Colombia), Hamburg (Germany), and Boston (Massachusetts), have been published previously (Alkelai et al, 2008; Bergen et al, 2009, 2011; Amstadter et al, 2010; Dai et al, 2012; Anderson-Schmidt et al, 2013, Akpudo et al, 2014).…”

Section: Introductionsupporting

confidence: 61%

Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12–16 October 2014

Aas

Blokland²,

Chawner

et al. 2016

Psychiatric Genetics

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The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Copenhagen, Denmark, on 12-16 October 2014. A total of 883 participants gathered to discuss the latest findings in the field. The following report was written by student and postdoctoral attendees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the oral presentations during the conference, and contains some of the major notable new findings reported.

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Section: Introductionsupporting

confidence: 61%

Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12–16 October 2014

Aas

Blokland²,

Chawner

et al. 2016

Psychiatric Genetics

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“…Indeed, no single locus had been robustly associated with schizophrenia when sample sizes were similar to those currently available for many other psychiatric disorders. The trajectory of GWAS discovery for schizophrenia, which increased from 1 locus (ISC ; Shi et al., ) to 7 (Ripke et al., ) to 22 (Ripke, O'Dushlaine, et al., ) to 62 (Anderson‐Schmidt et al., )to >100 (PGC‐SCZ, ) as the number of cases increased from ~3K to 36K, is not dissimilar to that of other (nonpsychiatric) diseases (Kim, Zerwas, Trace, & Sullivan, ). Whereas, the first 3K cases identified only 1 risk variant, the last 3K cases added to make the total of 36K cases identified ~40 additional loci).…”

Section: Discussionmentioning

confidence: 99%

Research Review: Polygenic methods and their application to psychiatric traits

Wray

Lee

Mehta

et al. 2014

Child Psychology Psychiatry

641

627

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Increasing the sample size for genome wide association studies of psychiatric disorders will lead to the identification of more associated genetic variants, as already found for schizophrenia. These loci provide the starting point of functional analyses that might eventually lead to new prevention and treatment options and to improved biological validity of diagnostic constructs. Polygenic analyses will contribute further to our understanding of complex genetic traits as sample sizes increase and as sample resources become richer in phenotypic descriptors, both in terms of clinical symptoms and of nongenetic risk factors.

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“…28) to 62 (ref. 29) to >100 (ref. 13) as the number of cases increased from ~3,000 to >35,000, is not dissimilar to that of other (non-psychiatric) diseases (Fig.…”

Section: Gwasmentioning

confidence: 99%

Large-scale genomics unveils the genetic architecture of psychiatric disorders

et al. 2014

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Family studies are consistent with genetic effects making substantial contributions to risk of psychiatric disorders such as schizophrenia, yet robust identification of specific genetic variants that explain variation in population risk had been disappointing until the advent of technologies that assay the entire genome in large samples. We highlight recent progress that has led to a better understanding of the number of risk variants in the population and the interaction of allele frequency and effect size. The emerging genetic architecture implies a large number of contributing loci (that is, a high genome-wide mutational target) and suggests that genetic risk to psychiatric disorders involves the combined effects of many common variants of small effect, as well as rare and de novo variants of large effect. The capture of a substantial proportion of genetic risk facilitates new study designs to investigate the combined effects of genes and the environment.

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Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14–18, 2012

Cited by 8 publications

References 108 publications

Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12–16 October 2014

Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12–16 October 2014

Research Review: Polygenic methods and their application to psychiatric traits

Large-scale genomics unveils the genetic architecture of psychiatric disorders

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