Selectin polymorphisms and perinatal morbidity in low‐birthweight infants

Derzbach, László; Bokodi, Géza; Treszl, András; Vásárhelyi, Barna; Nobilis, András; Rigó, János

doi:10.1080/08035250600575404

Cited by 22 publications

(11 citation statements)

References 27 publications

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“…They were selected partly from a cohort of neonates treated at the Second Department of Gynecology and Obstetrics, Semmelweis University (n = 92) and the participants were partly the same as those reported in earlier studies [26][27][28]. The other parts of the neonates (n = 33) were born in Veszprem County Hospital.…”

Section: Patientsmentioning

confidence: 99%

Association between birth weight in preterm neonates and the BclI polymorphism of the glucocorticoid receptor gene

Bertalan

Patócs

Vásárhelyi

et al. 2008

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Patientsmentioning

confidence: 99%

Association between birth weight in preterm neonates and the BclI polymorphism of the glucocorticoid receptor gene

Bertalan

Patócs

Vásárhelyi

et al. 2008

The Journal of Steroid Biochemistry and Molecular Biology

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“…In a retrospective Hungary-based study Derzbach et al 42 identified 125 LBW infants who were born between 1995 – 1999 and had a GA ranging from 24 – 36 weeks and BW 510-1500 grams. They were compared to 156 full term control infants.…”

Section: Candidate Genes Tag Snps Haplotypesmentioning

confidence: 99%

Progress in understanding the genetics of bronchopulmonary dysplasia

Shaw

O’Brodovich

2013

Seminars in Perinatology

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Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of infants. Its treatment imposes considerable health care burden and costs in the perinatal and early childhood period and patients are usually left with life-long deficits in lung function. Evidence exists for different pathophysiologic pathways that can promote the structural changes that characterize BPD, including the impairment in alveolarization; however, there is increasing interest regarding heritable factors that may predispose very low birth weight infants to BPD. Our review focuses on recent publications that have investigated genetic factors that may potentially contribute to such reported heritability. These publications point us towards some possible genomic candidates for further study, but certainly do not identify any particular gene or gene pathway that would be inferred to be contributing substantially to the underlying etiology of BPD.

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“…Aydemir et al 21 Härtel et al 9 Abu-Maziad et al 22 Auriti et al 23 Koroglu et al 24 Spiegler et al 25 Abdel-Hady et al 26 Bertalan et al 27 Reiman et al 28 Dzwonek et al 29 van Der Zwet et al 30 Schueller et al 31 Derzbach et al 32 Härtel et al 33 Baier et al 34 Göpel et al…”

Section: Questions (Q)unclassified

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

et al. 2013

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CONTEXT AND OBJECTIVE: Neonatal sepsis is associated with premature birth and maternal infection. Large-scale studies seek to define markers that identify neonates at risk of developing sepsis. Here, we examine whether the scientific evidence supports systematic use of polymorphism genotyping in cytokine and innate immunity genes, to identify neonates at increased risk of sepsis. DESIGN AND SETTING: Narrative literature review conducted at Fernandes Figueira Institute, Brazil. METHODS:The literature was searched in PubMed, Embase (Excerpta Medica Database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) and Cochrane Library. From > 400,000 references, 548 were retrieved based on inclusion/exclusion criteria; 22 were selected for detailed analysis after quality assessment. RESULTS:The studies retrieved addressed the impact of gene polymorphisms relating to immune mechanisms (most often TNF-a, LT-a, IL-6, IL-1β, IL-1ra, L-selectin, CD14 and MBL) or inflammatory mechanisms (ACE and angiotensin II receptors; secretory PLA2; and hemostatic factors). Despite initial reports suggesting positive associations between specific polymorphisms and increased risk of sepsis, the accumulated evidence has not confirmed that any of them have predictive power to justify systematic genotyping. CONCLUSIONS: Sepsis prediction through systematic genotyping needs to be reevaluated, based on studies that demonstrate the functional impact of gene polymorphisms and epidemiological differences among ethnically distinct populations. RESUMO CONTEXTO E OBJETIVO:A sepse neonatal está associada ao parto prematuro e à infecção materna. Estudos em grande escala buscam marcadores que identifiquem neonatos em risco de desenvolver sepse. Examinamos aqui se a evidência científica apoia o uso sistemático de genotipagem dos polimorfismos em genes de citocinas e imunidade inata, para identificar neonatos com risco elevado de sepse. TIPO DE ESTUDO E LOCAL:Revisão narrativa da literatura, Instituto Fernandes Figueira, Brasil. MÉTODOS: Busca online da literatura foi feita no PubMed, Embase (Excerpta Medica Database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Electronic Library Online) e Cochrane Library. De mais de 400.000 referências, 548 foram recuperadas com base nos critérios de inclusão/exclusão, e 22, selecionadas para análise detalhada após verificação da qualidade. RESULTADOS: Recuperamos estudos de impacto dos polimorfismos em genes relacionados com mecanismos imunes (mais frequentemente, TNF-a, LT-a, IL-6, IL-1β, IL-1ra, L-selectin, CD14, e MBL) ou inflamató-rios (ACE e receptores de angiotensina II; PLA2 secretória; fatores hemostáticos). Contrariando estudos que inicialmente sugeriram associação positiva entre polimorfismos específicos e risco aumentado de sepse, a evidência acumulada não confirmou, para qualquer deles, valor preditivo que justifique genotipagem sistemática para orientar antibioticoterapia. CONCLUSÕES: A...

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Selectin polymorphisms and perinatal morbidity in low‐birthweight infants

Abstract: Our results underline the importance of L-selectin in perinatal pathology, but further studies are needed to evaluate the alteration of L-selectin levels in carriers of the 213Ser allele and their possible contribution to premature birth and bronchopulmonary dysplasia.

Cited by 22 publications

References 27 publications

Association between birth weight in preterm neonates and the BclI polymorphism of the glucocorticoid receptor gene

Association between birth weight in preterm neonates and the BclI polymorphism of the glucocorticoid receptor gene

Progress in understanding the genetics of bronchopulmonary dysplasia

Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective

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