Selection for ovulation rate in rabbits: Direct and correlated responses estimated with a cryopreserved control population1

Laborda, Pablo; Santacreu, M. A.; Blasco, A.; Mocé, M. L.

doi:10.2527/jas.2011-4837

Cited by 12 publications

(15 citation statements)

References 16 publications

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“…In the rabbit selection experiment for ovulation rate cited earlier, the estimated difference between selected and control lines for prenatal survival from ovulation to birth was the same, -0.12 (HPD 95% =-0.20, -0.04; Laborda et al, 2012b). The results confirmed that a moderate increased of ovulation rate by hormonal treatment could be used to assess the timing of prenatal mortality in ovulation rate selection experiments.…”

Section: Survival Ratessupporting

confidence: 66%

“…Low concentration of eCG was used to increase ovulation rate to a level similar to that obtained after ten generations of selection for ovulation rate (Laborda et al, 2012b). In this selection experiment, an increase of 2.1 ova [highest posterior density region of the difference at 95% (HPD95%)=1.3, 2.9] was estimated but no correlated response in litter size was found due to a decrease in prenatal survival (-0.12 kits).…”

Section: Ovulation Rate Number Of Implanted Embryos and Foetusesmentioning

confidence: 95%

“…Usually, embryo mortality includes fertilisation failures and embryo losses. After 10 generations of selection by ovulation rate in rabbits, a negative correlated response in embryo survival, -0.05 (HPD 95% =-0.12, 0.02), was observed when the selected line was compared to a control line (Laborda et al, 2012b). Besides, in pigs, Koenig et al (1986) found a higher proportion of immature ova in selected females for high ovulation rate compared to unselected females, and in superovulated females compared to naturally ovulated ones; they suggest that immaturity of ova may account for a substantial proportion of prenatal mortality in gilts with high ovulation rate, either before or after implantation.…”

Section: Survival Ratesmentioning

confidence: 99%

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Effect of increased ovulation rate on embryo and foetal survival as a model for selection by ovulation rate in rabbits

et al. 2016

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Selection for ovulation rate in prolific species has not improved litter size, due to an increase in prenatal mortality, with most mortality observed in the foetal period. The aim of this study was to investigate the magnitude and timing of embryo and early foetal survival in females with high ovulation rate using hormonal treatment as a model for selection by ovulation rate. Two groups of females (treated and untreated) were used. Treated females were injected with 50 IU equine chorionic gonadotropin 48 h before mating. Females were slaughtered at 18 d of gestation. Ovulation rate (OR), number of implanted embryos (IE), number of live foetuses at 12 and 18 d (LF 12 and LF 18 , respectively) were recorded. In addition, embryo survival (ES=IE/OR), foetal survival at 18 d of gestation (FS LF18 =LF 18 /IE), foetal survival between 12 and 18 d of gestation (FS LF18/LF12 =LF 18 /LF 12 ) and prenatal survival (PS LF18 =LF 18 /OR) were estimated. For each female, the mean and variability of the weight for live foetuses (LFWm and LFWv, respectively) and their placentas (LFPWm and LFPWv, respectively) were calculated. Treated females had a higher ovulation rate (+3.02 ova) than untreated females, with a probability of 0.99. An increase in the differences (D) between treated and untreated females was observed from implantation to 18 d of gestation (D=-0.33, -0.70 and -1.28 for IE, LF 12 and LF 18 , respectively). These differences had a low accuracy and the probability that treated females would have a lower number of foetuses also increased throughout gestation (0.60, 0.70 and 0.86 for IE, LF 12 and LF 18 , respectively). According to the previous results for OR and LF 18 , treated females showed a lower survival rate from ovulation to 18 d of gestation (D=-0.12, P=0.98 for PS LF18 ). Treated females also had lower embryo and foetal survival (D=-0.10 and P=0.94 for ES and D=-0.08 and P=0.93 for FS LF18 ). Main differences in foetal survival appeared from 12 to 18 d of gestation (D=-0.09 and P=0.98 for FS LF18/LF12 ). Unexpectedly, treated females showed similar foetus weight and higher foetal placenta weight than untreated females (D=0.25 g, P=0.98) and lower variability for these traits (D=-0.02 g, P=0.72 for LFWv and D=-0.05 g, P=0.83 for LFPWv). These results are not related to a lower number of IE or LF 18 . Thus, the effect of increasing by three ova in rabbits leads to a lower embryo and early foetal survival. There seems to be no relationship between foetal mortality and foetus weight.

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Section: Survival Ratessupporting

confidence: 66%

Section: Ovulation Rate Number Of Implanted Embryos and Foetusesmentioning

confidence: 95%

Section: Survival Ratesmentioning

confidence: 99%

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Effect of increased ovulation rate on embryo and foetal survival as a model for selection by ovulation rate in rabbits

et al. 2016

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“…Cryopreservation of mammalian embryos has benefitted both breeding and biomedical research in recent decades, due in part to the improvement of techniques related to vitrification, freezing-thawing processes, and transfer procedures. To this end, rabbit embryo banking has allowed the preservation and spread of genetically superior animals over different countries [34] and the possibility of evaluating the genetic gain in maternal lines [4][5][6][7] without cumulative genetic drift variance [35]. Nevertheless, it is known that these techniques induce changes in environ-mental and maternal side effects modifying the embryo gene expression and methylation pattern [19,20,36], the transcriptomic and proteomic placental profile [21], and their viability [29,37], but little is known regarding the long-term effects on the derived progeny.…”

Section: Discussionmentioning

confidence: 99%

“…Strain rederivation from cryopreserved embryos has been used to assess the genetic improvement of quantitative traits such as prenatal survival, litter size, and growth characteristics in polytocous species such as mice, rats, and rabbits [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Embryo vitrification in rabbits: Consequences for progeny growth

et al. 2015

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The objective of this research is to examine if there are any effects of the rederivation procedures on rabbit growth pattern and on weight of different organ in adults. For this purpose, three experiments were conducted on two different groups of animals (control group and vitrified-transferred group) to evaluate the possible effect of embryo manipulation (vitrification and transfer procedures) on future growth traits. The first experiment studies body weight from 1 to 9 weeks of age from the two groups. The second experiment describes the growth curve of progeny from experimental groups and analyzes their Gompertz curve parameters, including the estimation of adult body weight. The third experiment has been developed to study if there are any differences in different organ weight in adult males from the two experimental groups. In general, the results indicate that rederivation procedures had effect on the phenotypic expression of growth traits. The results showed that rabbit produced by vitrification and embryo transfer had higher body weight in the first four weeks of age than control progeny. Results from body weight (a parameter) and b parameter estimated by fitting the Gompertz growth curve did not show any difference between experimental groups. However, differences related with growth velocity (k parameter of the Gompertz curve) were observed among them, showing that the control group had higher growth velocity than the vitrified-transferred group. In addition, we found that liver weight at 40th week of age exhibits significant differences between the experimental groups. The liver weight was higher in the control males than in the VF males. Although the present results indicate that vitrification and transfer pro-cedures might affect some traits related with growth in rabbits, further research is needed to assess the mechanisms involved in the appearance of these phenotypes and if these phenotypes could be transferred to the future progeny.

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Long-term and transgenerational effects of cryopreservation on rabbit embryos

et al. 2014

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ElsevierLavara García, R.; Baselga Izquierdo, M.; Marco Jiménez, F.; Vicente Antón, JS. (2014). Long-term and transgenerational effects of cryopreservation on rabbit embryos. Theriogenology. 81 (7) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Selection for ovulation rate in rabbits: Direct and correlated responses estimated with a cryopreserved control population1

Abstract: a cryopreserved control population Selection for ovulation rate in rabbits: Direct and correlated responses estimated with

Cited by 12 publications

References 16 publications

Effect of increased ovulation rate on embryo and foetal survival as a model for selection by ovulation rate in rabbits

Effect of increased ovulation rate on embryo and foetal survival as a model for selection by ovulation rate in rabbits

Embryo vitrification in rabbits: Consequences for progeny growth

Long-term and transgenerational effects of cryopreservation on rabbit embryos

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