Selection in Cladocera on the basis of a physiological character

Banta, Arthur Mangun

doi:10.5962/bhl.title.9936

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Biparental reproduction always leads to diapausing resting eggs encased in the ephippium, a derivative of the maternal carapace. In some cases biparental reproduction is lost; all females reproduce by obligate parthenogenesis, also with ephippia ("pseudosexual" eggs), and males are rare or absent (Olafsson 1918, Banta 1925and 1939, Schrader 1925, Hebert 1981, Hebert et al 1988and 1989, Crease et al 1989. Selection pressures are expected to be high because variations of limiting resources and selectively feeding predators are strong (Hall 1964, Jacobs 1977, Seitz 1980aand 1980b.…”

Section: Introductionmentioning

confidence: 99%

Microevolution in predominantly clonal populations of pelagic Daphnia (Crustacea: Phyllopoda): Selection, exchange, and sex

Jacobs

1990

J of Evolutionary Biology

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The study addresses the problem of gene pools and units of microevolution in mainly apomictic species. The genetic variation of Daphnia cucullata at the phosphoglucose-isomerase locus was studied in 6 lakes for 3-6 consecutive years. The two most distant lakes were 12 km apart. All lakes were sampled once a year; in one of the lakes (Klostersee), the main basin (WT) and the largest bay (WB, volume l/7 of WT) were sampled every month for 2; years.Three alleles and all six expected genotypes were found. Spatial differentiation was substantial, indicating lake-specific selection. There was a geographic gradient of allele frequencies without an apparent environmental gradient, suggesting exchange processes. Genotype frequencies in WB and WT showed marked fluctuations. They differed consistently between the two parts of the lake yet were highly correlated. The correlation was best if the WB frequencies were allowed to lag about one month behind the WT frequencies. This is to be expected if bay and basin experience different selection pressures but exchange parts of their populations, which requires some time. No parallel time lags were observed in environmental or demographic parameters. There was a significant correlation between fecundity (eggs/female) and genotype frequency, suggesting clone-specific differences in fitness.Biparental reproduction was very rare and superimposed on a continuum of parthenogenesis. Deviations from Hardy-Weinberg proportions were common and significant unless one allele was predominant. The direction of deviation of a given genotype frequency was usually the same in all lakes, suggesting overall differences in fitness between genotypes apart from lake-specific conditions of selection.

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Section: Introductionmentioning

confidence: 99%

Microevolution in predominantly clonal populations of pelagic Daphnia (Crustacea: Phyllopoda): Selection, exchange, and sex

Jacobs

1990

J of Evolutionary Biology

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“…Existe uma variedade de abordagens para a análise econômica de tecnologias em saúde, mas todas apresentam duas características centrais: (a) lidam tanto com os insumos quanto com os produtos -custos e consequências -das tecnologias ou intervenções em saúde; (b) comparam estratégias tecnológicas, podendo ser duas ou mais alternativas tecnológicas existentes para uma dada condição clínica ou mesmo intervenções diferentes disponíveis para condições de saúde diversas. 7 Há quatro técnicas ou tipos de análise econômica de saúde, com procedimentos para apuração de custos similares, mas que se diferenciam entre si pelas medidas das consequências: custo-benefício, no qual custos e efeitos são mensurados em unidades monetárias; custo-utilidade, o resultado é medido em unidades de utilidade, como o quality-adjusted life year (QALY); custo-efetividade, o efeito único é expresso em unidades naturais (casos evitados); e na análise de custo-minimização, assume-se que as duas intervenções apresentam benefícios semelhantes e custos diferentes. 8 A ATS mostra-se como uma grande necessidade na área laboratorial, sendo eminente a criação de estudos e metodologias para avaliação dessas tecnologias, buscando auxiliar nos processos de escolha entre as alternativas disponíveis; de modo a mensurar o benefício para cada unidade de custo para melhor aplicação dos recursos.…”

Section: Introductionunclassified

Avaliação de custo minimização dos processos de aquisição do exame de hemograma no laboratório central de Salvador-Bahia

Silva¹,

Rosim²

2022

JAFF

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Este trabalho teve como objetivo comparar a Licitação modalidade de Registro de Preços e Locação de máquinas com o fornecimento de insumos para a aquisição do exame de hemograma no Laboratório Central de Salvador-Bahia, por meio de uma análise de custo minimização. Para a realização dessa pesquisa foram considerados os dados referentes aos processos e registros documentais da Comissão Permanente de Licitação – órgão responsável pelos processos licitatórios finalizados pela Secretaria Municipal de Saúde. Foram elencados custos diretos, custos indiretos e custos intangíveis relativos aos processos. O estudo realizado sugere que os processos licitatórios realizados na modalidade Registro de preços conferem maior custo em relação a locação de máquinas, entretanto se faz necessário a aplicação de avaliação normativa e medição dos recursos aplicados nas aquisições aos resultados obtidos através de índices previamente parametrizados a fim de que, conforme requer este tipo de contrato, haja uma rigorosa avaliação na escolha da continuidade do serviço prestado, de modo a gerar economicidade dos recursos.

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“…Advances in genomic and proteomic methods 1 have increased knowledge of disease biomarkers at a rate that has outpaced the development of new molecularly targeted agents for diagnosis and therapy. Several classes of molecules can be applied to bridge this gap including engineered proteins [2][3][4] . A variety of scaffolds have shown therapeutic effectiveness as inhibitors, targeting agents for drug delivery, radioisotope carriers, and immune system engagers 5 as well as diagnostic success for early disease detection, patient stratification, and treatment monitoring 6 .…”

Section: Introductionmentioning

confidence: 99%

Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276

et al. 2019

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Yeast surface display is a proven tool for the selection and evolution of ligands with novel binding activity. Selections from yeast surface display libraries against transmembrane targets are generally carried out using recombinant soluble extracellular domains. Unfortunately, these molecules may not be good models of their true, membrane-bound form for a variety of reasons. Such selection campaigns often yield ligands that bind recombinant target but not targetexpressing cells or tissues. Advances in cell-based selections with yeast surface display may aid the frequency of evolving ligands that do bind true, membrane-bound antigens. This study aims to evaluate ligand selection strategies using both soluble target-driven and cellular selection techniques to determine which methods yield translatable ligands most efficiently and generate novel binders against CD276 (B7-H3) and Thy1, two promising tumor vasculature targets. Out of four ligand selection campaigns carried out using only soluble extracellular domains, only an affibody library sorted against CD276 yielded translatable binders. In contrast, fibronectin domains against CD276 and affibodies against CD276 were discovered in campaigns that either combined soluble target and cellular selection methods or used cellular selection methods alone. A high frequency of non-target specific ligands discovered from the use of cellular selection methods alone motivated the development of a depletion scheme using disadhered, antigen-negative mammalian cells as a blocking agent. Affinity maturation of CD276-binding affibodies by errorprone PCR and helix walking resulted in strong, specific cellular CD276 affinity (K d = 0.9 ± 0.6 nM). Collectively, these results motivate the use of cellular selections in tandem with recombinant selections and introduces promising affibody molecules specific to CD276 for further applications.

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Selection in Cladocera on the basis of a physiological character

Cited by 5 publications

References 11 publications

Microevolution in predominantly clonal populations of pelagic Daphnia (Crustacea: Phyllopoda): Selection, exchange, and sex

Microevolution in predominantly clonal populations of pelagic Daphnia (Crustacea: Phyllopoda): Selection, exchange, and sex

Avaliação de custo minimização dos processos de aquisição do exame de hemograma no laboratório central de Salvador-Bahia

Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276

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