2014
DOI: 10.1016/j.fct.2013.10.030
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Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: Considerations of biological relevance of tumour type, data quality and uncertainty assessment

Abstract: This article addresses a number of concepts related to the selection and modelling of carcinogenicity data for the calculation of a Margin of Exposure. It follows up on the recommendations put forward by the International Life Sciences Institute - European branch in 2010 on the application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic. The aims are to provide practical guidance on the relevance of animal tumour data for human carcinogenic hazard assessment, … Show more

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Cited by 29 publications
(23 citation statements)
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“…It is flexible and can be adapted to fit within the time available, including urgent situations. The most up-to-date detailed description of the approach is included in a paper by Edler et al (2013).…”
Section: 5mentioning
confidence: 99%
See 4 more Smart Citations
“…It is flexible and can be adapted to fit within the time available, including urgent situations. The most up-to-date detailed description of the approach is included in a paper by Edler et al (2013).…”
Section: 5mentioning
confidence: 99%
“…small, medium, large impacts), but in some later examples a quantitative scale is provided (see below). The most up-to-date detailed description of the approach is included in a paper by Edler et al (2013, …”
Section: Uncertainty Tables For Quantitiesmentioning
confidence: 99%
See 3 more Smart Citations