A regression model is derived for the separation of nonuniform liquid systems with non-Newtonian properties by dual-stage pressure flotation in a film-flow regime created in the centrifugal force field in hydrocyclones. The regression model is presented in the form of a relationship between integral separation indicators in the cyclone and determining similitude numbers and rheologic properties of the dispersion medium. The model makes it possible to calculate with an accuracy sufficient for practical purposes the structural and regime parameters of cylindrical-conical and cylindrical hydrocyclones/flotation plants as a function of assigned integral separation indicators at the outlet from the vessel.Assurance of high-intensity separation of heterogeneous liquid systems by pressure flotation is possible when it is carried out in hydrocyclones. Cylindrical and cylindrical-conical hydrocyclones are structurally simple, reliable, and at the same time, highly efficient. They permit pressure flotation a centrifugal force field in the film-flow regime of the medium being separated; this appreciably improves their separation indicators.In familiar studies on hydrocyclones, several attempts have been made to derive semi-empirical and empirical relationships to describe certain elements of the hydrodynamics of the vessels [1]. These relationships have not been applied on a practical basis, however, in connection with the complexity of their use in determining integral separation indicators within the hydrocyclones.Orlov [2] and Alekseev et al. [3] have established that the centrifugal field is a factor that increases the number of collisions between particles and bubbles, and also derived a relationship between the number of probable collisions and centrifugal acceleration.Familiar methods used to analyze the separation of heterogeneous liquid systems by flotation in hydrocyclones [4-6], which are based on solution of the differential equation of motion of the particle-bubble complex, are unacceptable for separation processes where film flows of highly viscous non-Newtonian liquids exist in a field of centrifugal forces, which permit appreciable intensification of the separation rate in hydrocyclones.