Selection of the appropriate method for the assessment of insulin resistance

Borai, Anwar; Livingstone, Callum; Kaddam, Ibrahim; Ferns, Gordon A.

doi:10.1186/1471-2288-11-158

Cited by 206 publications

(156 citation statements)

References 74 publications

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“…The authors speculated that insulin sensitivity and glucose disposal could be influenced by the muscle relaxing action of this drug, but this hypothesis has never been definitely proved so far [16]. Similarly, the variations on Matsuda index we observed should be interpreted cautiously, though the lack of statistical significance could be related to the small number of subjects studied [17,18].…”

Section: Discussionmentioning

confidence: 58%

Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Gramaglia

Gigliardi

Olivetti

et al. 2014

J Endocrinol Invest

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This is the author's final version of the contribution published as: Gramaglia E;Ramella Gigliardi V;Olivetti I;Tomelini M;Belcastro S;Calvi E;Dotta A;Ghigo E;Benso A;Broglio F. Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects.. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 37 Conclusions: This study suggests that BZ and imidazopyridines have a rapid glucometabolic effect that is detectable as early as after 15 days treatment.3

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Section: Discussionmentioning

confidence: 58%

Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Gramaglia

Gigliardi

Olivetti

et al. 2014

J Endocrinol Invest

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“…33 , 34 The euglucemic hyperinsulinemic clamp and the frequently-sampled intravenous glucose tolerance test are the worldwide-accepted gold standards. 33 , 35 Their complexity, availability and cost, however, make them not ideal in many clinical scenarios. 33 Although with some well-recognized limitations, most current publications suggest the HOMA-IR index to classify IR.…”

Section: Discussionmentioning

confidence: 99%

“…33 , 35 Their complexity, availability and cost, however, make them not ideal in many clinical scenarios. 33 Although with some well-recognized limitations, most current publications suggest the HOMA-IR index to classify IR. 36 , 37 Studies in adults have defined a value ≥2.5 as the cut-off for IR.…”

Section: Discussionmentioning

confidence: 99%

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance

González-Saldivar

Rodríguez-Gutiérrez

Treviño-Alvarez

et al. 2018

Dermato-Endocrinology

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Any clinical/biochemical marker revealing obesity or diabetes before their appearance is valuable. Insulin resistance (IR) is present in both disorders many years before occurrence. Accordingly, we determined whether acanthosis nigricans (AN) in the knuckles is associated to higher insulin and homeostasis model assessment for estimated insulin resistance (HOMA-IR) index values, and assessed the influence of body-mass index (BMI) and the diagnostic performance of AN in the knuckles to detect IR. In this cross-sectional controlled study, we included men or women, 18 to 23 years old, with or without AN in the knuckles. In 149 cases with AN in the knuckles and 145 controls, fasting insulin was higher in cases (13.45 µU/mL ± 7.8 vs. 8.59 µU/mL ± 3.63, P < .001, respectively). Mean HOMA-IR index was also higher (2.86 ± 1.68 vs. 1.78 ± 0.77, P < .001). A significant increase in fasting insulin and HOMA-IR values between and within BMI groups from normal through obese category was identified in controls and cases. By multivariate regression analysis, cases with normal BMI were significantly associated to a HOMA-IR ≥2.5 (OR = 3.09, CI95% = 1.75–5.48, P = .001). A model of AN in the knuckles, normal BMI, and increased waist circumference allowed identifying 2 out of 3 cases with HOMA-IR index ≥2.5. AN in the knuckles could be addressed with two aims: as an easy, accessible, and costless diagnostic tool suggesting hyperinsulinemia secondary to IR, and, an early marker of IR even in the absence of overweight or obesity.

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“…AUC glukosa dihitung dengan memplotkan ke-7 nilai gula darah serial, dihitung luas area di bawah kurva dengan metode penghitungan trapezoid. 9 Kadar MDA plasma diukur dengan metode thiobarbituric acid reactive substance (TBARS) menggunakan spektrofotometri. 11 Karena MDA bersifat tidak stabil, digunakan larutan standar tetraetoksipropan (TEP).…”

Section: Gambar 2 Pengukuran Panjang Nasoanalunclassified

Potensi Suplementasi Resveratrol dalam Mengatasi Efek Negatif Hormon Tiroid pada Terapi Obesitas: Uji Preklinik

Ruslami¹,

Rosalita²,

Yolanda³

et al. 2016

mkb

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AbstrakTerapi obesitas menggunakan hormon tiroid menurunkan berat badan dengan nyata, namun menyebabkan berbagai efek negatif seperti stres oksidatif, kerusakan DNA, dan muscle wasting. Penelitian ini bertujuan mengkesplorasi potensi resveratrol (RSV), polifenol alami yang mempunyai efek antioksidan, anti-inflamasi, dan antiobesitas. Uji preklinik dengan rancangan acak sederhana dilakukan di Lab Hewan Fakultas Kedokteran Universitas Padjadjaran menggunakan 40 ekor tikus Wistar yang diinduksi obesitas. Hewan model obesitas dialokasikan secara acak ke dalam dua kelompok selama periode Agustus-November 2014. Kelompok perlakuan mendapat hormon tiroid 3 (HT3) dan RSV, serta kelompok kontrol mendapat HT3 saja selama 14 hari. Hewan coba yang mendapat HT3 dan RSV memiliki bobot badan lebih besar (290,5 g vs 251 g, p=0,016), massa otot lebih berat (2,57 g vs 2,25 g, p=0,036), indeks adiposit lebih kecil (0,89% vs 1,02%, p=0,026), dan area under the curve (AUC) gukosa lebih kecil (1.849,2 mg.mnt/dL vs 2.591,7 mg.mnt/dL, p<0,001) dibanding yang mendapat HT3 saja. Tidak terdapat perbedaan kadar MDA plasma (0,49 nmol/mL vs 0,44 nmol/mL, p=0,430) dan kerusakan DNA (19,7 pixel vs 22,0 pixel, p=0,657) pada kedua kelompok yang mungkin berhubungan dengan dosis dan lama pemberian resveratrol. Suplementasi resveratrol berpotensi mengatasi efek negatif hormon tiroid pada hewan model obesitas. Perlu penelitian lanjutan untuk mengetahui dosis optimal resveratrol sebagai antioksidan pada pengobatan obesitas menggunakan hormon tiroid. Treatment of obesity using thyroid hormone could give significant result in decreasing body weight, but it also causes various negative effects such as oxidative stress, DNA damage, and muscle wasting. This sudy aimed to explore the potential of resveratrol, a natural polyphenol, that has anti-oxidant, anti-inflammatory, and anti-obesity effects, in managing negative effects of thyroid hormone used as anti-obesity. A preclinical trial was conducted at the animal laboratory, Faculty of Medicine, Universitas Padjadjaran. Forty male Wistar rats underwent obesity induction before randomly allocated into intervention and control groups in August-November 2014. The intervention group received a 14-days of triiodothyronine (T3) and resveratrol (RSV), while the control group received T3 only. Obese rats treated with T3 and RSV were heavier (body weight of 290.5 g vs 251.0 g, p<0.016), had a heavier muscle mass (2.57 g vs 2.25 g, p=0.036), smaller adipocyte index, (0.89% vs 1.02%, p=0.026) and smaller glucose area under the curve (AUC) (1,848.2 mg.mnt/dL vs 2,591.7 mg.mnt/dL, p<0.001) than those who were treated with T3 only. There was no significance difference in MDA plasma levels (0.49 nmol/mL vs 0.44 nmol/mL, p=0.0430) and DNA damage (19.7 pixel vs 22.0 pixel, p=0.657) between groups, probably due to insufficient dosage of resveratrol. Our results indicate that resveratrol supplementation could counter negative effects of thyroid hormone used as anti-obesity in obese-rats model treated with T3. More research is...

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Selection of the appropriate method for the assessment of insulin resistance

Cited by 206 publications

References 74 publications

Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance

Potensi Suplementasi Resveratrol dalam Mengatasi Efek Negatif Hormon Tiroid pada Terapi Obesitas: Uji Preklinik

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