Selective and sensitive colorimetric detection of Hg(II) in aqueous solution by quinone-diimidazole ensemble with mimicking YES-OR-INHIBIT logic gate operation

Parthiban, C.; Elango, Kuppanagounder P.

doi:10.1016/j.snb.2016.06.085

Cited by 19 publications

(5 citation statements)

References 40 publications

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Section: Imidazole-based Supermolecules As Ion Receptorsmentioning

confidence: 99%

“…Compound III10 with one molecule of mercury ions could form a complex via the nitrogen on imidazole. The addition of Hg (II) ions to III10 led to fluorescence quenching with a limit of detection of 10 nM [448]. Benzimidazole-based sensor III9, which could be used to detect zinc ions and form the Zn (II) complex, was synthesized and was found to be highly selective as a fluorogenic chemosensor and in the solid-state sensor mode for the detection of Zn (II) ions.…”

Section: Imidazole-based Supermolecules As Cation Receptors For Mercu...mentioning

confidence: 99%

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Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

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The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.

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Section: Imidazole-based Supermolecules As Ion Receptorsmentioning

confidence: 99%

Section: Imidazole-based Supermolecules As Cation Receptors For Mercu...mentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

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“…1,4-Quinone core has been identified as a privileged structural scaffold in various pharmaceuticals, natural products, and materials chemistry [21][22][23][24]. As a result, tremendous efforts have been put into the development of functionalized quinones [25,26].…”

Section: Introductionmentioning

confidence: 99%

Scaffold Hopping and Structural Modification of NSC 663284: Discovery of Potent (Non)Halogenated Aminobenzoquinones

Bayrak,

Sever,

Ciftci

et al. 2023

Biomedicines

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The development of new anticancer drugs is still ongoing as a solution to the unsatisfactory results obtained by chemotherapy patients. Our previous studies on natural product-based anticancer agents led us to synthesize a new series of Plastoquinone (PQ) analogs and study their anticancer effects. Four members of PQ analogs (PQ1–4) were designed based on the scaffold hopping strategy; the design was later completed with structural modification. The obtained PQ analogs were synthesized and biologically evaluated against different cancer genotypes according to NCI-60 screening in vitro. According to the NCI results, bromo and iodo-substituted PQ analogs (PQ2 and PQ3) showed remarkable anticancer activities with a wide-spectrum profile. Among the two selected analogs (PQ2 and PQ3), PQ2 showed promising anticancer activity, in particular against leukemia cell lines, at both single- and five-dose NCI screenings. This compound was also detected by MTT assay to reveal significant selectivity between Jurkat cells and PBMC (healthy) compared to imatinib. Further in silico studies indicated that PQ2 was able to occupy the ATP-binding cleft of Abl TK, one of the main targets of leukemia, through key interactions similar to dasatinib and imatinib. PQ2 is also bound to the minor groove of the double helix of DNA. Based on computational pharmacokinetic studies, PQ2 possessed a remarkable drug-like profile, making it a potential anti-leukemia drug candidate for future studies.

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“…However, the spectrometric method has the advantages of simplicity, rapidity, low cost and high sensitivity, which is used in various fields. [12][13][14][15][16][17] In recent years, the spectrometric method had attracted the attention of many researchers because of its high selectivity, sensitivity, simplicity and real-time usability. [18][19][20][21][22][23] Until now, many excellent works about Hg 2＋ sensors have been successfully obtained through different designing thoughts by the introduction of special functional groups to different optical matrixes, and have displayed impressive probing performance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Sulfonylhydrazone Type Probe with High Selectivity for Rapid Detection of Mercury and Its Application in Adsorption and HeLa Cell

Xue¹,

Xie²,

Chu³

et al. 2021

Chinese Journal of Organic Chemistry

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). 在二甲基亚砜(DMSO)/H 2 O (V∶V＝7∶3, pH＝7)溶液体系中, S1 对 Hg 2＋展示出快速响应、高选择和高荧光灵敏性. 通过 1 H NMR 和 HRMS 探究了可能的机理. 聚丙烯酰胺(PAM)掺杂 S1 (PAMS)对 Hg 2＋有高的吸附性能, 其去除率达到 99.99%, 并且在紫外灯下通过肉眼很容易区分. 通过扫描电子显微镜(SEM)观察了 PAMS 吸附前后的微观形貌. 此外, S1 具有优异的生物相容性, 可以极好地检测 HeLa 细胞中的 Hg 2＋ .

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Selective and sensitive colorimetric detection of Hg(II) in aqueous solution by quinone-diimidazole ensemble with mimicking YES-OR-INHIBIT logic gate operation

Cited by 19 publications

References 40 publications

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Scaffold Hopping and Structural Modification of NSC 663284: Discovery of Potent (Non)Halogenated Aminobenzoquinones

Synthesis of Sulfonylhydrazone Type Probe with High Selectivity for Rapid Detection of Mercury and Its Application in Adsorption and HeLa Cell

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