Selective and Simple Determination of Isoquinoline Alkaloids in Papaver Species by Ion Mobility Spectrometry

Tajabadi, Fatemeh; Khalighi-Sigaroodi, Farahnaz; Nahooji, Majid Ghorbani; Ghiaci-Yekta, Mona; Ghasemi, Vahid

doi:10.5812/ijpr-127037

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Borgognoni also used the seeds (recipes #1, 2, 8) and leaves (recipe #3) of P. somniferum . Both these matrices have been recently analyzed, and these results have highlighted that both contain morphine and thebaine, while leaves also contain codeine [ 11 ]. These recent outcomes further validated the effectiveness of Borgognoni’s treatments.…”

Section: Resultsmentioning

confidence: 99%

Teodorico Borgognoni’s Formulary for Thirteenth Century Anesthetic Preparations

Cavalloro,

Soddu,

Baroni

et al. 2023

Life

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Teodorico Borgognoni was born in Lucca in 1205 and was appointed bishop of Bitonto and Cervia in 1262 and 1270. Following his father, he learned the art of surgery and collected relevant recipes in his most important work, entitled Cyrurgia seu filia principis. Among the disciplines reported in this work, the most interesting and innovative is anesthesia. The recipes in this field contribute to Borbognoni’s consideration as the forerunner of modern anesthesia. Such recipes have been reported in other manuscripts from the Middle Ages, like Manuscript No. 1939. In the present work, we investigate the traditional preparations handed down in this manuscript, focusing on type of preparation and botanical ingredients. The results highlight that exploited ingredients can be divided into three groups: the first comprises plants already known for their narcotic effects, the second includes ingredients acting as an adjuvant for absorption or reducing the metabolism, and the last group includes ingredients not associated with biological activity to explain their presence in anesthetic recipes. This third group is of particular interest for future biological investigations. Our goal is to rekindle attention to the work of Teodorico Borgognoni on traditional preparation for anesthetic purposes: a topic often underestimated by ethnobotanical surveys.

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Section: Resultsmentioning

confidence: 99%

Teodorico Borgognoni’s Formulary for Thirteenth Century Anesthetic Preparations

Cavalloro,

Soddu,

Baroni

et al. 2023

Life

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“…Codeine was also extracted in abundant amounts from all plant parts of all Papaver species. The highest amount of morphine was extracted from the leaf samples (64.24 mg/g), but it was detected only by IMS 73 …”

Section: Analytical Approaches For Estimation Of Alkaloidsmentioning

confidence: 98%

“…The highest amount of morphine was extracted from the leaf samples (64.24 mg/g), but it was detected only by IMS. 73 Girme and coworkers developed and validated a UHPLC-ESI-MS/ MS bioanalytical method for the detection of bioactive phytoconstituents from the Ayurvedic botanical Guduchi (Tinospora cordifolia). The researchers quantified four compounds from the extract of Tinospora cordifolia, namely, tinosporide, 20-β-hydroxyecdysone, jatrorrhizine, and tetrahydropalamatine, in the plasma of male Sprague-Dawley rats.…”

Section: Isoquinoline Alkaloidsmentioning

confidence: 99%

An insight into recent updates on analytical techniques for bioactive alkaloids

Saini,

Seni,

Chawla

et al. 2024

Phytochemical Analysis

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IntroductionAlkaloids represent a wide class of naturally existing nitrogen‐containing organic compounds having diverse biological activities. They are primary bioactive substances extracted from diverse plant parts. Due to their diverse biological activities, they are frequently used as medicines. The alkaloids have diverse pharmacological impacts on the human body; alkaloids are used for prevention, treatment, and reduction of discomfort associated with chronic illnesses. As most alkaloids exist in plants in complex form, combined with numerous other natural plant components, it is essential to recognize and characterize these molecules using different analytical techniques.ObjectivesWe aimed to review the literature on the methods and protocols for the analysis of naturally occurring alkaloids.MethodsWe carried out a literature survey using the PubMed, Scopus, and Google Scholar databases and other relevant published materials. The keywords used in the searches were “alkaloids,” “analytical methods,” “HPLC method,” “GC method,” “electrochemical methods,” and “bioanalytical methods,” in various combinations.ResultsIn this article, several classes of alkaloids are presented, along with their biological activities. Moreover, it includes a thorough explanation of chromatographic techniques, hyphenated techniques, electrochemical techniques, and current trending analytical methods utilized for the isolation, identification, and comprehensive characterization of alkaloids.ConclusionsThe various analytical techniques play an important role in the identification as well as the characterization of various alkaloids from plants, plasma samples, and urine samples. The hyphenation of various chromatographic techniques with mass spectrometry and NMR spectroscopy plays a crucial role in the characterization of unknown compounds.

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