“…The superior rate of CBD cannulation when using DGT has been attributed to the capability of the pancreatic guidewire to straighten both the PD and CBD while at the same time occupying the PD, thus facilitating CBD cannulation and preventing repeated PD cannulation. [18][19][20] These promising results of DGT prompted us to design a multicenter randomized trial with a significant number of patients (addressing the limitations reported by some authors 25,26 ) to test the hypothesis that in patients with difficult CBD cannulation, DGT has a higher success rate and/or fewer attempts required to achieve it compared with standard cannulation technique (SCT). 11 …”