Selective BuChE inhibitory activity, chemical composition, and enantiomer content of the volatile oil from the Ecuadorian plant Clinopodium brownei

Matailo, Andrea; Bec, Nicole; Calva, James; Ramírez, Jorge; Andrade, José Miguel; Larroque, Christian; Vidari, Giovanni; Armijos, Chabaco

doi:10.1016/j.bjp.2019.08.001

Cited by 17 publications

(19 citation statements)

References 43 publications

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“…In this context, the study of EO cholinesterase inhibitory activity is a relatively new area of research; in particular, the oil mechanisms of action have been poorly investigated so far. It is, therefore, of great interest that several EOs described in this review exhibited such inhibitory effects; in particular, the highly selective BuChE inhibitory activity exhibited by Clinopodium brownei [58], Coreopsis triloba [35], Myrcianthes myrsinoides [77], and Salvia leucantha [66] EOs is worthy of further studies. Equally interesting is the ChEI activity that was found for the flavonoid tiliroside, the diterpene carnosol (30) [1], and the alkaloids found in a few Phaedranassa species [17,18].…”

Section: Discussionmentioning

confidence: 94%

“…In in vitro tests, the EO showed high selective inhibitory activity against BuChE, with an IC 50 = 13.4 ± 1.8 mg/mL. In contrast, it was weakly active against AChE with an IC 50 > 250 µg/mL [58].…”

Section: Poleo Chico or Poleo Warmi Chico In Kichwamentioning

confidence: 94%

“…Oxygenated monoterpenes (86.06%), followed by oxygenated sesquiterpenes (5.36%), constituted the most abundant fractions. The enantiomeric compositions of β-pinene, sabinene, 3-octanol, menthone, pulegone, and methyl acetate were determined using enantioselective GC/MS [58]. (−)-Menthone showed the highest enantiomeric excess (ee = 83.4%) [58].…”

Section: Poleo Chico or Poleo Warmi Chico In Kichwamentioning

confidence: 99%

“…The enantiomeric compositions of β-pinene, sabinene, 3-octanol, menthone, pulegone, and methyl acetate were determined using enantioselective GC/MS [58]. (−)-Menthone showed the highest enantiomeric excess (ee = 83.4%) [58].…”

Section: Poleo Chico or Poleo Warmi Chico In Kichwamentioning

confidence: 99%

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Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

et al. 2021

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The use of plants as therapeutic agents is part of the traditional medicine that is practiced by many indigenous communities in Ecuador. The aim of this study was to update a review published in 2016 by including the studies that were carried out in the period 2016–July 2021 on about 120 Ecuadorian medicinal plants. Relevant data on raw extracts and isolated secondary metabolites were retrieved from different databases, resulting in 104 references. They included phytochemical and pharmacological studies on several non-volatile compounds, as well as the chemical composition of essential oils (EOs). The tested biological activities are also reported. The potential of Ecuadorian plants as sources of products for practical applications in different fields, as well the perspectives of future investigations, are discussed in the last part of the review.

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Section: Discussionmentioning

confidence: 94%

Section: Poleo Chico or Poleo Warmi Chico In Kichwamentioning

confidence: 94%

Section: Poleo Chico or Poleo Warmi Chico In Kichwamentioning

confidence: 99%

Section: Poleo Chico or Poleo Warmi Chico In Kichwamentioning

confidence: 99%

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Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

et al. 2021

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“…Pulegone, isopulegone, piperitone, piperitenone, piperitenone oxide, menthone, isomenthone and menthol are the main constituents. 1,8-Cineole, menthofuran, carvacrol, thymol, linalool and their derivatives can also seldom be found [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The second group is decidedly less common, and includes species like Clinopodium umbrosum (M.Bieb.)…”

Section: Discussionmentioning

confidence: 99%

A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador

et al. 2020

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A novel chemical profile essential oil, distilled from the aerial parts of Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), was analysed by Gas Chromatography-Mass Spectrometry (GC-MS, qualitative analysis) and Gas Chromatography with Flame Ionization Detector (GC-FID, quantitative analysis), with both polar and non-polar stationary phase columns. The chemical composition mostly consisted of sesquiterpenes and sesquiterpenoids (>70%), the main ones being (E)-β-caryophyllene (17.8%), α-copaene (10.5%), β-bourbonene (9.9%), δ-cadinene (6.6%), cis-cadina-1(6),4-diene (6.4%) and germacrene D (4.9%), with the non-polar column. The essential oil was then submitted to enantioselective GC analysis, with a diethyl-tert-butyldimethylsilyl-β-cyclodextrin diluted in PS-086 chiral selector, resulting in the following enantiomeric excesses for the chiral components: (1R,5S)-(−)-α-thujene (67.8%), (1R,5R)-(+)-α-pinene (85.5%), (1S,5S)-(−)-β-pinene (90.0%), (1S,5S)-(−)-sabinene (12.3%), (S)-(−)-limonene (88.1%), (S)-(+)-linalool (32.7%), (R)-(−)-terpinen-4-ol (9.3%), (S)-(−)-α-terpineol (71.2%) and (S)-(−)-germacrene D (89.0%). The inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of C. taxifolium essential oil was then tested, resulting in selective activity against BChE with an IC50 value of 31.3 ± 3.0 μg/mL (positive control: donepezil, IC50 = 3.6 μg/mL).

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Fumigant toxicity of essential oils against Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae): a systematic review and meta-analysis

et al. 2021

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Selective BuChE inhibitory activity, chemical composition, and enantiomer content of the volatile oil from the Ecuadorian plant Clinopodium brownei

Cited by 17 publications

References 43 publications

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador

Fumigant toxicity of essential oils against Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae): a systematic review and meta-analysis

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