Selective depression of T‐lymphocyte subsets in gastric cancer patients: An implication of immunotherapy

Lee, Wei-Jei; Chang, King‐Jen; Lee, Chue-Shue; Chen, Kai-Mo

doi:10.1002/jso.2930550307

Cited by 23 publications

(20 citation statements)

References 18 publications

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“…Thus, the CD4/CD8 ratio increased in patients with gastric cancer. Note that the increase in the CD4/CD8 ratio contradicts data obtained in a previous study (3). Various investigators have not detected significant modifications of CD8+ lymphocyte populations in gastric cancer patients.…”

Section: Discussioncontrasting

confidence: 70%

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Effect of surgical treatment on the cellular immune response of gastric cancer patients

Barbieri

Fujisawa

Yasuda

et al. 2003

Braz J Med Biol Res

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Patients with gastric cancer have a variety of immunological abnormalities. In the present study the lymphocytes and their subsets were determined in the peripheral blood of patients with gastric cancer (N = 41) both before and after surgical treatment. The percent of helper/ inducer CD4 T cells (43.6 ± 8.9) was not different after tumor resection (43.6 ± 8.2). The percent of the cytotoxic CD8+ T cell population decreased significantly, whether patients were treated surgically (27.2 ± 5.8%, N = 20) or not (27.3 ± 7.3%, N = 20) compared to individuals with inflammatory disease (30.9 ± 7.5%) or to healthy individuals (33.2 ± 7.6%). The CD4/CD8 ratio consequently increased in the group of cancer patients. The peripheral blood lymphocytes of gastric cancer patients showed reduced responsiveness to mitogens. The defective blastogenic response of the lymphocytes was not associated with the production of transforming growth factor beta (TGF-ß) since the patients with cancer had reduced production of TGF-ß1 (269 ± 239 pg/ml, N = 20) in comparison to the normal individuals (884 ± 175 pg/ml, N = 20). These results indicate that the immune response of gastric cancer patients was not significantly modified by surgical treatment when evaluated four weeks after surgery and that the immunosuppression observed was not due to an increase in TGF-ß1 production by peripheral leukocytes. Correspondence

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Section: Discussioncontrasting

confidence: 70%

“…Many gastric cancer patients have a variable degree of immunological impairment, including decreased cellular immunity (2,3). Immunity to cancer is known to be affected by the function of the lymphocyte subsets, consisting of helper/inducer CD4 T cells and cytotoxic/suppressor CD8+ T cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of surgical treatment on the cellular immune response of gastric cancer patients

Barbieri

Fujisawa

Yasuda

et al. 2003

Braz J Med Biol Res

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“…Many gastric cancer patients have a variable degree of immunological impairment, including decreased cellular immunity [41,42]. Cytokines such as interferons, interleukin and tumor necrosis factor have been widely tested in the treatment of cancer.…”

Section: Discussionmentioning

confidence: 99%

Lycopene Enhances Antioxidant Enzyme Activities and Immunity Function in N-Methyl-N′-nitro-N-nitrosoguanidine–Induced Gastric Cancer Rats

Luo

2011

IJMS

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To investigate anticancer effect of lycopene, we examined the effects of lycopene on the oxidative injury and immunity activities of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer rats. The animals were divided into five groups. Group I served as the normal control and was given corn oil orally for 20 weeks. Group II were induced with MNNG 200 mg/kg body weight by oral gavage at days 0 and 14, and saturated NaCl (1 mL per rats) was given once every three days for four weeks until the end of the experimental period. Group III, IV and V were posttreated with lycopene (50, 100 and 150 mg/kg body weight, dissolved in corn oil) from the sixth week of MNNG (as in group II) induction up to the end of the experimental period. In the presence of MNNG, MDA and immunity levels were significantly increased, whereas enzymatic (SOD, CAT, and GPx) antioxidant activities were decreased in the treated rats compared with normal control rats. Administration of lycopene to gastric carcinoma-induced rats largely up-regulated the redox status and immunity activities to decrease the risk of cancer compared to group II. We conclude that up-regulation of antioxidants and immunity by lycopene treatment might be responsible for the anticancer effect in gastric carcinoma.

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“…Previous reports, however, have found an association between lymphopenia and neoplasia progression. 32,33 Lymphatic involvement is one of the most important prognostic factors in gastric cancer. 12,34 The prognostic value of LR in the evaluation of lymph node status found in this study confirms the results from previous studies.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Score in Gastric Cancer: The Importance of a Conjoint Analysis of Clinical, Pathologic, and Therapeutic Factors

et al. 2006

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Background: This study was designed to establish a prognostic score for gastric cancer that takes into account factors related to the tumor, the patient, and the treatment.Methods: Two hundred thirty patients with gastric adenocarcinoma admitted to the Department of Abdominal Surgery at Hospital do Caˆncer A. C. Camargo (Sa˜o Paulo) and treated by gastrectomy from January 1992 until December 1996 were included in this retrospective cohort. The prognostic score was created according to the variables identified in the multivariate analysis and by using the regression coefficients generated by the Cox regression.Results: The 5-year overall survival rate was 44.5%. The final multivariate model identified six variables with a significant and independent effect on survival: sex, weight loss, lymphocyte count, tumor-node-metastasis staging, lymphadenectomy, and lymph node ratio. Patients were divided into four groups according to their scores, as follows: group 1, 0 to 3.0; group 2, 3.5 to 5.5; group 3, 6.0 to 8.5; and group 4, 9.0 to 14.0. The 5-year survival rates were 91.5%, 49.3%, 20.3%, and .0% for the score groups 1, 2, 3, and 4, respectively (P < .001). The score was superior in the assessment of prognosis when compared with tumor-node-metastasis staging alone.Conclusions: It is possible to create a prognostic score that simultaneously includes factors related to the tumor, patient, and treatment, thus generating a more effective system in predicting the prognosis than the morphology-based staging systems.

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Selective depression of T‐lymphocyte subsets in gastric cancer patients: An implication of immunotherapy

Cited by 23 publications

References 18 publications

Effect of surgical treatment on the cellular immune response of gastric cancer patients

Effect of surgical treatment on the cellular immune response of gastric cancer patients

Lycopene Enhances Antioxidant Enzyme Activities and Immunity Function in N-Methyl-N′-nitro-N-nitrosoguanidine–Induced Gastric Cancer Rats

Prognostic Score in Gastric Cancer: The Importance of a Conjoint Analysis of Clinical, Pathologic, and Therapeutic Factors

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