Selective Detection of Creatinine Using Enzymatic Route for Diagnosis of Chronic Kidney Diseases

Abstract

Chronic kidney diseases are becoming very common health issues due to growing age, hypertension, and high cholesterol which causes poor kidney functioning and eventual creatinine issues. Creatinine is a serum present in blood and urine that measures kidney function. We have designed a highly-sensitive and precise sensor for creatinine sensing. Eu-doping in tin oxide (SnO2) is used to enhance the sensitivity and limit of detection. A precise working range of this sensor is also found by the calibration curve between full-width at half maximum and figure of merit with respect to the concentration of creatinine. A selectivity experiment with enzymatic route is followed to make this sensor selective for creatinine only. This sensor may find plentiful deliberation in field of sensing and mainly medical applications.