Selective deuterium exchange during superheated heavy water chromatography–nuclear magnetic resonance spectroscopy–mass spectrometry of sulfonamides

Smith, Roger M.; Chienthavorn, Orapin; Saha, Shikha; Wilson, Ian D.; Wright, Brian; Taylor, Stephen D.

doi:10.1016/s0021-9673(00)00493-3

Cited by 36 publications

(22 citation statements)

References 13 publications

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“…Smith and coworkers [35,38,45,48,61] reported the use of NMR-and MS-spectrometric detection in SBWC. Because proton NMR-spectrometry was used in this approach, high-temperature heavy water (deuterium oxide) was employed as the mobile phase.…”

Section: Nmr- Ms- Ir-spectrometric and Other Detection Methodsmentioning

confidence: 99%

“…Because proton NMR-spectrometry was used in this approach, high-temperature heavy water (deuterium oxide) was employed as the mobile phase. A specific and efficient deuteration of methyl groups on a pyrimidine was observed during the chromatographic separation process of certain sulfonamides [48]. Therefore, this approach may serve as a means for studying oncolumn reactions.…”

Section: Nmr- Ms- Ir-spectrometric and Other Detection Methodsmentioning

confidence: 99%

“…The most widely used polymer columns in SBWC are PRP-1 [11,15,18,19,30,34,63] and PLRP-S (PS-DVB) [10,14,26,35,37,38,43,47,48,62]. The use of Oasis packing has also been reported [43].…”

Section: Polymer Packingsmentioning

confidence: 99%

“…A number of classes of organic compounds have been separated by SBWC. They include carbohydrates [15][16][17][18], amino acids [15,17,18], alcohols [11,[19][20][21][22][23][24], carboxylic acids [8,15], phenols [8-11, 18, 24-30], anilines [9,18,30], phosphonic acids [17], PTH-amino acids [31][32][33], aldehydes [34], water-soluble vitamins [35], caffeine derivatives [11,14,27,36,37], parabens [10,26,37], barbiturates [10,26,38], steroids [33,[39][40][41][42], model drugs [43][44][45][46], sulfonamides [47,48], flavones [49], triazole fungicides …”

Section: Introductionmentioning

confidence: 99%

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Subcritical water chromatography: A green approach to high‐temperature liquid chromatography

Yang¹

2007

J of Separation Science

105

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At temperatures and pressures lower than 374 degrees C and 218 atm, subcritical water has widely tunable properties such as dielectric constant, surface tension, viscosity, and dissociation constant achieved by simply adjusting the temperature with a moderate pressure to keep water in the liquid state. At elevated temperatures, water acts like a weak polar organic solvent. Thus, subcritical water has been used as a green eluent to replace hazardous solvents commonly used as organic modifiers in RPLC. Subcritical water chromatography (SBWC) is capable of separating polar, moderately polar, and even some nonpolar analytes. Most of these low molecular weight solutes are stable at elevated temperatures during a chromatographic run. Some new packing materials are also quite stable and robust at mild temperatures ranging from 80 to 150 degrees C. Advantages of SBWC include the elimination of hazardous organic solvents used in traditional RPLC, rapid analysis time, improved selectivity, temperature-dependent separation efficiency, temperature-programmed elution, and compatibility with both gas- and liquid-phase detectors. In this paper, the technical aspects as well as the applications of SBWC are reviewed. Topics addressed in this review include the unique characteristics of subcritical water, analytes separated by SBWC, packing materials tested for SBWC, the application of GC and LC detection techniques in SBWC, SBWC instrumentation development, temperature effects on SBWC separation, and models developed for separation in SBWC.

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Section: Nmr- Ms- Ir-spectrometric and Other Detection Methodsmentioning

confidence: 99%

Section: Nmr- Ms- Ir-spectrometric and Other Detection Methodsmentioning

confidence: 99%

“…The most widely used polymer columns in SBWC are PRP-1 [11,15,18,19,30,34,63] and PLRP-S (PS-DVB) [10,14,26,35,37,38,43,47,48,62]. The use of Oasis packing has also been reported [43].…”

Section: Polymer Packingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Subcritical water chromatography: A green approach to high‐temperature liquid chromatography

Yang¹

2007

J of Separation Science

105

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show abstract

“…Some researchers have already proven the usefulness of this technique. [4][5][6][7][8][9][10][11][12][13][14][15][16] In most cases, poly(styrenedivinylbenzene) (PSDVB) packings were used as the stationary phase, [4][5][6][7][8][9][10][11][12][13][14][15] because of their thermal-stability in size-exclusion chromatography and conventional RP-HPLC. Octadecylsilyl (ODS)-silica gels have also been employed at column temperatures above 100˚C.…”

mentioning

confidence: 99%

Superheated Water Chromatography of Phenols Using Poly(styrene-divinylbenzene) Packings as a Stationary Phase

2003

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2000

J. Mass Spectrom.

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Selective deuterium exchange during superheated heavy water chromatography–nuclear magnetic resonance spectroscopy–mass spectrometry of sulfonamides

Cited by 36 publications

References 13 publications

Subcritical water chromatography: A green approach to high‐temperature liquid chromatography

Subcritical water chromatography: A green approach to high‐temperature liquid chromatography

Superheated Water Chromatography of Phenols Using Poly(styrene-divinylbenzene) Packings as a Stationary Phase

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