2008
DOI: 10.1128/jvi.02102-07
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Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2

Abstract: Human immunodeficiency virus type 1 (HIV-1) Nef downregulates HLA-A and -B molecules, but not HLA-C or -E molecules, based on amino acid differences in their cytoplasmic domains to simultaneously evade cytotoxic T lymphocyte (CTL) and natural killer cell surveillance. Rhesus macaques and sooty mangabeys express orthologues of HLA-A, -B, and -E, but not HLA-C, and many of these molecules have unique amino acid differences in their cytoplasmic tails. We found that these differences also resulted in differential … Show more

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Cited by 26 publications
(37 citation statements)
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“…Signatures associated with group A, whether they were from the N01 or N10, were primarily linked to the myristoylation domain of nef (Table 7). Signatures associated with group C, whether they were from macaque N10 or macaque N02, contained amino acid signatures in a domain associated with major histocompatibility complex class I (MHC-I) downregulation (53)(54)(55).…”
Section: The Cd4mentioning
confidence: 99%
“…Signatures associated with group A, whether they were from the N01 or N10, were primarily linked to the myristoylation domain of nef (Table 7). Signatures associated with group C, whether they were from macaque N10 or macaque N02, contained amino acid signatures in a domain associated with major histocompatibility complex class I (MHC-I) downregulation (53)(54)(55).…”
Section: The Cd4mentioning
confidence: 99%
“…Thus, Nef facilitates viral evasion of both innate and adaptive immune responses by simul-taneously preventing NK cell killing and reducing CTL recognition of HIV-1-infected cells. Not surprisingly, this selective nature of Nef-mediated MHC-I down-regulation is conserved among different groups of primate lentiviruses (10,36).…”
mentioning
confidence: 99%
“…Nef downregulates highly polymorphic HLA-A and -B molecules as a mechanism of HIV-1 immune evasion, but not HLA-C or -E molecules which frequently serve as ligands to inhibit the activation of NK cells (Lanier, 2005). This selection is broadly conserved between SIV (smm/mac) and HIV-2 Nef alleles (DeGottardi et al, 2008). Moreover, differences in HLA downmodulation by Nef are based on amino acid modifications in HLA cytoplasmic domains, which implies that diverse properties of Nef are required to achieve the simultaneous evasion of the CTL and natural killer cell surveillance by HIV (DeGottardi et al, 2008;Lanier, 2005).…”
Section: Downmodulation Of Cd4 and Mhc-imentioning
confidence: 99%
“…This selection is broadly conserved between SIV (smm/mac) and HIV-2 Nef alleles (DeGottardi et al, 2008). Moreover, differences in HLA downmodulation by Nef are based on amino acid modifications in HLA cytoplasmic domains, which implies that diverse properties of Nef are required to achieve the simultaneous evasion of the CTL and natural killer cell surveillance by HIV (DeGottardi et al, 2008;Lanier, 2005). Nef is sufficiently adaptable to maintain downregulation of MHC-I and CD4 as a two independent functions and neither activity is optimized by the transmission event, despite the changing in immune pressure associated with sexual transmission (Noviello et al, 2007).…”
Section: Downmodulation Of Cd4 and Mhc-imentioning
confidence: 99%